Correspondence
Fronts of Internal Emergency Medicine Research for Years to Come Xiao‑Jun He1, Zhen‑Ying Chen2 1
Department of Chinese Journal of Emergency Medicine, Medical College, The Second Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, China 2 Library of Zhejiang University, Hangzhou, Zhejiang 310027, China
To the Editor: As we have known, Emergency Medicine is an interdisciplinary subject and has many hot spots for research. However, many researchers often worry that their research is too narrowed or not so cutting edge as to be accepted by journals with high impact factor (IFs). Why? One reason perhaps lies in the fact that many of them have difficulty in following the fronts and hot spots in internal Emergency Medicine research. Here, we introduce the use of Essential Science Indicator (USA) tools to analyze the frontier and cutting edge researches in the field of internal Emergency Medicine, and we hope this can help researchers in finding research fronts.
The 5 hotspots of internal Emergency Medicine research were “sepsis,” “acute pulmonary,” “trauma,” “shock” and “cardiopulmonary resuscitation.” Yes, sepsis is the hottest subject in Emergency Medicine. Although there are already some large studies published in top medicine journals about Surviving Sepsis Campaign Protocols (SSCP),[1‑6] SSCP is still the hottest front for years to come. The followed hotspots are acute lung injury; the most attention were paid on the acute respiratory distress syndrome, receptor signaling, and acute lung injury evaluation. And others can refer to the Table 1.
Table 1: The keywords and fronts of internal Emergency Medicine research Subjects
Fronts
Sepsis
Multicenter Severe Sepsis Educational Program; Surviving Sepsis Campaign Protocols; Program Targeting Severe Sepsis Campaign; Results are Sepsis; Surviving Critically Ill Immunocompetent Patients; Severe Sepsis; Sepsis; Critically Injured Humans; Immunosuppression Early Sepsis Therapy; Early Lactate‑guided Therapy; Randomized Clinical Trial; Severe Sepsis Independent; Lactate Clearance Severe Sepsis; Albumin; Patients; Sepsis; Resuscitation Fluid Early Onset Neonatal Sepsis; Proven Early‑onset Bacterial Sepsis; Group B Streptococcal; Coli Disease Continues Acute lung injury Acute Respiratory Distress Syndrome Systematic; Severe Acute Respiratory Distress Syndrome; Early Acute Respiratory Distress Syndrome; Acute Respiratory Distress Syndrome; Acute Lung Injury Critically Ill Patients; Eden Randomized Trial; Early Enteral Nutrition; Acute Lung Injury Randomized; Early Parenteral Nutrition Experimental Acute Lung Injury; Acute Lung Injury; Official American Thoracic Society Workshop Report; Animal Models; Features A2b Adenosine Receptor Signaling; Alveolar Fluid Clearance; Acute Lung Injury; Ischemic Preconditioning; New Paradigm Lower Tidal Volumes; Acute Lung Injury; Lung Protective Mechanical Ventilation; Conventional Tidal Volumes; Acute Respiratory Distress Syndrome Acute Lung Injury Evaluation; Lung Injury Prediction Score; Acute Respiratory Distress Syndrome; Early Identification; 8‑year Trend Transfusion‑related Acute Lung Injury; Transfusion‑associated Circulatory Overload; Plasma Transfusion; Risk Factors; Incidence Acute pulmonary Acute Symptomatic Pulmonary Embolism; Acute Pulmonary Embolism; Hemodynamically Stable Pulmonary Embolism; injury Pulmonary Embolism Severity Index; Submassive Pulmonary Embolism Cryoballoon Pulmonary Vein Isolation Results; Circumferential Pulmonary Vein Isolation; Acute Pulmonary Vein Isolation; Pulmonary Vein Isolation; Paroxysmal Atrial Fibrillation First Results Trauma Bleeding Trauma Patients; Major Trauma Patients; 466 Massively Transfused Civilian Trauma Patients; Trauma Patients; Major Blunt Trauma Chronic Traumatic Encephalopathy; Single Traumatic Brain Injury; Traumatic Brain Injury; Retired National Football League Players; Subconcussive Brain Trauma
Contd... Access this article online Quick Response Code:
Website: www.cmj.org
DOI: 10.4103/0366-6999.154333
Chinese Medical Journal ¦ April 5, 2015 ¦ Volume 128 ¦ Issue 7
Address for correspondence: Xiao‑Jun He, Department of Chinese Journal of Emergency Medicine, The Second Hospital of Zhejiang University, Medical College, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China E‑Mail: [email protected] 989
Table 1: Contd... Subjects
Fronts
Epigenetic Mechanisms; Epigenetic Profiles; Allele‑specific Fkbp5 DNA Demethylation; Gene‑childhood Trauma Interactions; PTSD Trauma Symptoms; Potential Trauma; Resilience; Deployed US Military Service Members; Prospective Cohort Cochlear Hair Cell Regeneration; Human ES‑cell‑derived Otic Progenitors; Auditory Evoked Responses; Notch Inhibition; Acoustic Trauma Sleep Disturbances; Combat Trauma, PTSD; Prazosin; Active‑duty Soldiers Returned Bougie‑related Airway Trauma; Traffic Light Bougie; Hold‑up Sign; Safety Modification; Dangers Shock Septic Shock; Shock; Critically Ill Adult Patients; Patients; Norepinephrine Infusion Inappropriate Implantable Cardioverter‑defibrillator Shocks Incidence; Inappropriate Implantable Cardioverter‑defibrillator Shocks; Multicenter Thermocool Ventricular Tachycardia Ablation Trial; Implantable Cardioverter‑defibrillator Patients; Implant Old Keynesian Government Spending Multipliers; Fiscal Policy Shocks; Government Spending Shocks; Government Spending Multiplier Large; Fiscal Shocks Oil Price Shocks; Exogenous Oil Supply Shocks; Crude Oil Market; Oil Market VAR Models; Crude Oil Prices Hsp90 Inhibitor Active; Hsp90; 5‑diarylisoxazole Hsp90 Chaperone Inhibitors; Small‑molecule Inhibitors; Inhibitors Stress‑regulated MicroRNAs; Drought‑responsive MicroRNAs; Stress‑Responsive MiRNAs; MiRNA Expression Patterns; Shock Drought Stress Human Septic Shock; Septic Shock; Inappropriate Antimicrobial Therapy Results; Early Goal‑directed Therapy; Survival Small Heat Shock Proteins; Dynamic Proteins; Structural Mechanisms; Structural Basis; Alpha B‑crystallin Oligomers Hsp90 Molecular Chaperone Inhibitors; Hsp90 Inhibitors; Cancer Dependencies; Clinical Development Remittances; Philippine Migrants Exchange Rate Shocks; Household Investment; International Migration; Financial Development Solar Cells Approach; State‑of‑the‑art Photovoltaic Cells; Radiative Efficiency; Shockley-Queisser Limit; Strong Internal Shock Wave‑facilitated Intracoronary Cell Therapy; Cardiopoietic Stem Cell Therapy; Chronic Heart Failure; Heart Failure; Cellwave Randomized Clinical Trial Molecular Chaperone Hsp90; Anti‑cancer Agents; Basic Discoveries; Clinical Development; Future Directions Cardiopulmonary Resuscitation Outcomes Consortium Epistry‑Cardiac Arrest; Out‑of‑Hospital Cardiac Arrest; Out‑of‑hospital Cardiac Arrests; resuscitation Chest‑compression‑only Cardiopulmonary Resuscitation; Children In‑hospital Pediatric Cardiac Arrests; In‑hospital Cardiac Arrest; Illness Category Impact Survival; Cardiopulmonary Resuscitation; Resuscitation Efforts PTSD: Posttraumatic stress disorder; Hsp90: Heat shock protein 90; ES: Embryonic stem; miRNA: MicroRNA.
References 1. ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, et al. A randomized trial of protocol‑based care for early septic shock. N Engl J Med 2014;370:1683‑93. 2. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580‑637. 3. Lilly CM. The ProCESS trial – A new era of sepsis management. N Engl J Med 2014;370:1750‑1. 4. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal‑directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368‑77. 5. Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N,
990
et al. High versus low blood‑pressure target in patients with septic shock. N Engl J Med 2014;370:1583‑93. 6. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA, et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: A randomized clinical trial. JAMA 2010;303:739‑46.
Received: 23-12-2014 Edited by: Yuan-Yuan Ji How to cite this article: He XJ, Chen ZY. Fronts of Internal Emergency Medicine Research for Years to Come. Chin Med J 2015;128:989-90. Source of Support: Nil. Conflict of Interest: None declared.
Chinese Medical Journal ¦ April 5, 2015 ¦ Volume 128 ¦ Issue 7
Fronts of Internal Emergency Medicine Research for Years to Come Xiao‑Jun He1, Zhen‑Ying Chen2 1
Department of Chinese Journal of Emergency Medicine, Medical College, The Second Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, China 2 Library of Zhejiang University, Hangzhou, Zhejiang 310027, China
To the Editor: As we have known, Emergency Medicine is an interdisciplinary subject and has many hot spots for research. However, many researchers often worry that their research is too narrowed or not so cutting edge as to be accepted by journals with high impact factor (IFs). Why? One reason perhaps lies in the fact that many of them have difficulty in following the fronts and hot spots in internal Emergency Medicine research. Here, we introduce the use of Essential Science Indicator (USA) tools to analyze the frontier and cutting edge researches in the field of internal Emergency Medicine, and we hope this can help researchers in finding research fronts.
The 5 hotspots of internal Emergency Medicine research were “sepsis,” “acute pulmonary,” “trauma,” “shock” and “cardiopulmonary resuscitation.” Yes, sepsis is the hottest subject in Emergency Medicine. Although there are already some large studies published in top medicine journals about Surviving Sepsis Campaign Protocols (SSCP),[1‑6] SSCP is still the hottest front for years to come. The followed hotspots are acute lung injury; the most attention were paid on the acute respiratory distress syndrome, receptor signaling, and acute lung injury evaluation. And others can refer to the Table 1.
Table 1: The keywords and fronts of internal Emergency Medicine research Subjects
Fronts
Sepsis
Multicenter Severe Sepsis Educational Program; Surviving Sepsis Campaign Protocols; Program Targeting Severe Sepsis Campaign; Results are Sepsis; Surviving Critically Ill Immunocompetent Patients; Severe Sepsis; Sepsis; Critically Injured Humans; Immunosuppression Early Sepsis Therapy; Early Lactate‑guided Therapy; Randomized Clinical Trial; Severe Sepsis Independent; Lactate Clearance Severe Sepsis; Albumin; Patients; Sepsis; Resuscitation Fluid Early Onset Neonatal Sepsis; Proven Early‑onset Bacterial Sepsis; Group B Streptococcal; Coli Disease Continues Acute lung injury Acute Respiratory Distress Syndrome Systematic; Severe Acute Respiratory Distress Syndrome; Early Acute Respiratory Distress Syndrome; Acute Respiratory Distress Syndrome; Acute Lung Injury Critically Ill Patients; Eden Randomized Trial; Early Enteral Nutrition; Acute Lung Injury Randomized; Early Parenteral Nutrition Experimental Acute Lung Injury; Acute Lung Injury; Official American Thoracic Society Workshop Report; Animal Models; Features A2b Adenosine Receptor Signaling; Alveolar Fluid Clearance; Acute Lung Injury; Ischemic Preconditioning; New Paradigm Lower Tidal Volumes; Acute Lung Injury; Lung Protective Mechanical Ventilation; Conventional Tidal Volumes; Acute Respiratory Distress Syndrome Acute Lung Injury Evaluation; Lung Injury Prediction Score; Acute Respiratory Distress Syndrome; Early Identification; 8‑year Trend Transfusion‑related Acute Lung Injury; Transfusion‑associated Circulatory Overload; Plasma Transfusion; Risk Factors; Incidence Acute pulmonary Acute Symptomatic Pulmonary Embolism; Acute Pulmonary Embolism; Hemodynamically Stable Pulmonary Embolism; injury Pulmonary Embolism Severity Index; Submassive Pulmonary Embolism Cryoballoon Pulmonary Vein Isolation Results; Circumferential Pulmonary Vein Isolation; Acute Pulmonary Vein Isolation; Pulmonary Vein Isolation; Paroxysmal Atrial Fibrillation First Results Trauma Bleeding Trauma Patients; Major Trauma Patients; 466 Massively Transfused Civilian Trauma Patients; Trauma Patients; Major Blunt Trauma Chronic Traumatic Encephalopathy; Single Traumatic Brain Injury; Traumatic Brain Injury; Retired National Football League Players; Subconcussive Brain Trauma
Contd... Access this article online Quick Response Code:
Website: www.cmj.org
DOI: 10.4103/0366-6999.154333
Chinese Medical Journal ¦ April 5, 2015 ¦ Volume 128 ¦ Issue 7
Address for correspondence: Xiao‑Jun He, Department of Chinese Journal of Emergency Medicine, The Second Hospital of Zhejiang University, Medical College, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China E‑Mail: [email protected] 989
Table 1: Contd... Subjects
Fronts
Epigenetic Mechanisms; Epigenetic Profiles; Allele‑specific Fkbp5 DNA Demethylation; Gene‑childhood Trauma Interactions; PTSD Trauma Symptoms; Potential Trauma; Resilience; Deployed US Military Service Members; Prospective Cohort Cochlear Hair Cell Regeneration; Human ES‑cell‑derived Otic Progenitors; Auditory Evoked Responses; Notch Inhibition; Acoustic Trauma Sleep Disturbances; Combat Trauma, PTSD; Prazosin; Active‑duty Soldiers Returned Bougie‑related Airway Trauma; Traffic Light Bougie; Hold‑up Sign; Safety Modification; Dangers Shock Septic Shock; Shock; Critically Ill Adult Patients; Patients; Norepinephrine Infusion Inappropriate Implantable Cardioverter‑defibrillator Shocks Incidence; Inappropriate Implantable Cardioverter‑defibrillator Shocks; Multicenter Thermocool Ventricular Tachycardia Ablation Trial; Implantable Cardioverter‑defibrillator Patients; Implant Old Keynesian Government Spending Multipliers; Fiscal Policy Shocks; Government Spending Shocks; Government Spending Multiplier Large; Fiscal Shocks Oil Price Shocks; Exogenous Oil Supply Shocks; Crude Oil Market; Oil Market VAR Models; Crude Oil Prices Hsp90 Inhibitor Active; Hsp90; 5‑diarylisoxazole Hsp90 Chaperone Inhibitors; Small‑molecule Inhibitors; Inhibitors Stress‑regulated MicroRNAs; Drought‑responsive MicroRNAs; Stress‑Responsive MiRNAs; MiRNA Expression Patterns; Shock Drought Stress Human Septic Shock; Septic Shock; Inappropriate Antimicrobial Therapy Results; Early Goal‑directed Therapy; Survival Small Heat Shock Proteins; Dynamic Proteins; Structural Mechanisms; Structural Basis; Alpha B‑crystallin Oligomers Hsp90 Molecular Chaperone Inhibitors; Hsp90 Inhibitors; Cancer Dependencies; Clinical Development Remittances; Philippine Migrants Exchange Rate Shocks; Household Investment; International Migration; Financial Development Solar Cells Approach; State‑of‑the‑art Photovoltaic Cells; Radiative Efficiency; Shockley-Queisser Limit; Strong Internal Shock Wave‑facilitated Intracoronary Cell Therapy; Cardiopoietic Stem Cell Therapy; Chronic Heart Failure; Heart Failure; Cellwave Randomized Clinical Trial Molecular Chaperone Hsp90; Anti‑cancer Agents; Basic Discoveries; Clinical Development; Future Directions Cardiopulmonary Resuscitation Outcomes Consortium Epistry‑Cardiac Arrest; Out‑of‑Hospital Cardiac Arrest; Out‑of‑hospital Cardiac Arrests; resuscitation Chest‑compression‑only Cardiopulmonary Resuscitation; Children In‑hospital Pediatric Cardiac Arrests; In‑hospital Cardiac Arrest; Illness Category Impact Survival; Cardiopulmonary Resuscitation; Resuscitation Efforts PTSD: Posttraumatic stress disorder; Hsp90: Heat shock protein 90; ES: Embryonic stem; miRNA: MicroRNA.
References 1. ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, et al. A randomized trial of protocol‑based care for early septic shock. N Engl J Med 2014;370:1683‑93. 2. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580‑637. 3. Lilly CM. The ProCESS trial – A new era of sepsis management. N Engl J Med 2014;370:1750‑1. 4. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal‑directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368‑77. 5. Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N,
990
et al. High versus low blood‑pressure target in patients with septic shock. N Engl J Med 2014;370:1583‑93. 6. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA, et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: A randomized clinical trial. JAMA 2010;303:739‑46.
Received: 23-12-2014 Edited by: Yuan-Yuan Ji How to cite this article: He XJ, Chen ZY. Fronts of Internal Emergency Medicine Research for Years to Come. Chin Med J 2015;128:989-90. Source of Support: Nil. Conflict of Interest: None declared.
Chinese Medical Journal ¦ April 5, 2015 ¦ Volume 128 ¦ Issue 7
