Bio-Medical Materials and Engineering 24 (2014) 3–6 DOI 10.3233/BME-130776 IOS Press
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Guest-editorial
Frontiers in Biomedical Engineering and Biotechnology Feng Liu a,* , Ali Goodarzi b , Haifeng Wang c , Joanna Stasiak d , Jianbo Sun e and Yu Zhou f a International
School of Software, Wuhan University, No. 37 Luoyu Road, Wuhan, 430070, China Medical School, Harvard University, 25 Shattuck Street, Boston, MA 02115, USA c Department of Diagnostic Radiology, Yale University, 5 Sheldon Terrace, New Haven, CT 06511, USA d Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK e Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, USA f Inspirees International in The Netherlands, The Netherlands b Harvard
Abstract. The 2nd International Conference on Biomedical Engineering and Biotechnology (iCBEB 2013), held in Wuhan on 11–13 October 2013, is an annual conference that aims at providing an opportunity for international and national researchers and practitioners to present the most recent advances and future challenges in the fields of Biomedical Information, Biomedical Engineering and Biotechnology. The papers published by this issue are selected from this conference, which witnesses the frontier in the field of Biomedical Engineering and Biotechnology, which particularly has helped improving the level of clinical diagnosis in medical work. Keywords: Biomedical engineering, iCBEB
1. Introduction Health problem is a key problem in human being, which prompts more and more scientists and engineers get involved in this field. To improve the accuracy of diagnosis, new methods and advanced technology are applied to assist clinical diagnosis and biological experiments. To provide a good platform for researchers and experts to communicate, the 2nd International Conference on Biomedical Engineering and Biotechnology (iCBEB 2013) is held on 11–13 October 2013 in Wuhan [1]. The iCBEB 2013 is an international conference held annually that aims at providing an opportunity for international *
Corresponding author. E-mail: [email protected].
0959-2989/14/$27.50 © 2014 – IOS Press and the authors. All rights reserved
4
F. Liu et al. / Frontiers in Biomedical Engineering and Biotechnology
and national researchers and practitioners to present their most recent studies in the fields of Biomedical Information, Biomedical Engineering and Biotechnology. The first conference was held on 28th to 30th May 2012 in Macau, which was technically sponsored by University of Macau and IEEE [1]. In 2013, the conference mainly includes 7 tracks: Biomechanical Engineering, Biomedical Engineering, Biomaterials, Biotechnology, Biosensors and Bio-signal Processing, Biomedical imaging, and Bioinformatics.
2. Highlighted papers Recommended by the conference committees and reviewers, some papers are highlighted as follow. 2.1. Biomechanical engineering The paper New clinical failure mode triggered by a new coronary stent design proposes a computational LSC model using finite element analysis. Simulation results show that the connector number plays the most significant role in the development of the LSC issue [2]. Results show the LSC could be improved by up to 30% when the design pattern changes from the offset peak-to-peak design (Element) to the peak-to-peak design (Endeavor). The paper Mucoadhesive polymer films for tissue retraction in laparoscopic surgery: Ex-vivo study on their mechanical properties concludes that adhesive polymers can stick to the serosal side of the bowel with an adhesive force, which is sufficient to lift the bowel, providing a lower retraction stress than that caused by laparoscopic grasping which induces high localized pressures on the tissue [3]. 2.2. Biomedical engineering The paper Interactive Cell Segmentation based on Phase Contrast Optics proposes an interactive cell segmentation scheme over phase retardation features. Experimental results demonstrate that cells with different optical properties are well segmented via the proposed approach [4]. The paper Research and Development of Compact Wrist Rehabilitation Robot System develops the compact rehabilitation robot system which can support movement of the wrist of patients [5]. The robot system can detect and analyze the patient’s intention to move the wrist by such a biological signal as muscle potential, then, assist the wrist exercise of patients. 2.3. Biomaterials The paper Mechanical strength of sutured block copolymers films for load bearing medical applications studies the mechanical behavior of three styrenic thermoplastic block copolymer elastomers with applied surgical sutures [6]. The authors observe the distinct macroscopic deformation mechanisms upon stretching of samples with vertical and horizontal orientation. The paper Effect of Nd:YAG laser nitriding-treated titanium nitride surface of Ti6Al4V substrate on the activity of MC3T3-E1 cells reports results that the TiN surface formed by Nd:YAG laser nitriding is favorable for the proliferation and differentiation of MC3T3-E1 cells, which may allow them to be utilized for implant surface modification [7].
F. Liu et al. / Frontiers in Biomedical Engineering and Biotechnology
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2.4. Biotechnology The paper Transcriptional Suppression of Human Apolipoprotein A4 and Apolipoprotein C3 Genes by Phorbol Myristate Acetate in Hepatic and Intestinal Cells achieves results that PMA specifically down regulates the transcription of apoA4 and apoC3, but exhibits no effects on apoA1 or apoA5 in either HepG2 or Caco-2 cells. The suppressive effect of PMA on apoA4 and apoC3 results from its regulation of the transcription rate of the two genes [8]. The authors concludes that PMA down-regulates the transcription of apoA4 and apoC3 possibly through the common regulatory element shared by these two genes, suggesting a suppressive role of PKC on the transcriptional regulation of specific apo lipoproteins in hepatic and intestinal cells. 2.5. Biosensors and bio-signal processing The paper Establishment of dsDNA/GNs/chit/GCE biosensor and electrochemical study on interaction between 6-mercaptopurine and DNA gives the results that, after the modification of GNs-chit, the electrode activation area of GNs/chit/GCE increases remarkably, which is improved from 1.76 cm2 to 8.64 cm2 , and the responsive oxidation peak current of GNs/chit/GCE to K3 [Fe(CN)6 ] also increases remarkably. Meanwhile the research also demonstrates that DNA is effectively fixed on the GNs/chit/GCE electrode; 6-MP causes obvious damage to dsDNA, and the damage degree on the adenine is bigger than that on the guanine; the interaction between 6-MP and dsDNA is preliminarily deduced as the intercalation, and its electrochemical oxidation process is an irreversible process controlled by the adsorption [9]. 2.6. Biomedical imaging The paper Bias Correction for Magnetic Resonance Images via Joint Entropy Regularization exploits the spatial and gradient features of the corrupted MR images for bias correction via the joint entropy regularization and proposes two nonparametric bias correction algorithms namely IsoTVBiasC and AniTVBiasC. The test results show that the proposed two methods can effectively remove the bias field [10].
Acknowledgements We are grateful to conference committee members of iCBEB 2013 for their support and guidance. We would like to thank the anonymous reviewers including most TPC members for their careful review of the full papers. We would like to particularly thank Tomasz Dlugosz from Wroclaw University of Technology in Poland, Yiyun Cheng from East China Normal University in China, Peng Li from Shandong University in China, Chung-Yuan Chen from Sitronix Technology Corp., Sadreddin Baharnezhad from Islamic Azad University South Tehran, Joung Hwan from Sungkyunkwan University in South Korea, Asaduzzaman Khan from Central South University in China, Wei Li from the Second Military Medical University in China. They have viewed dozens of manuscripts for this conference. Additionally, special thanks are given to Prof. Dongsheng Liu from Tsinghua University, Prof. Ng Yin Kwee from Nanyang Technological University, Dr. Tomasz Długosz, from Wroclaw University of Technology, Dr. Yu Zhou from Inspirees International in The Netherlands, Maarten Fröhlich from IOS Press for their special contributions to this conference. All the great efforts from above people have made this conference successful.
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References [1] iCBEB, International Conference on Biomedical Engineering and Biotechnology, http://www.icbeb.org. [2] Hao-Ming Hsiao, Chun-Ting Yeh, Yi-Hsiang Chiu, Chun Wang and Chun-Pei Chen, New clinical failure mode triggered by a new coronary stent design, Bio-Medical Materials and Engineering 24(1) (2014), 37–43. [3] Zhigang Wang, Lik-Ren Tai, Donald McLean, Emma J. Wright et al., Mucoadhesive polymer films for tissue retraction in laparoscopic surgery: Ex-vivo study on their mechanical properties, Bio-Medical Materials and Engineering 24(1) (2014), 445–451. [4] Hang Su, Zhou Su, Shibao Zheng, Hua Yang and Sha Wei, Interactive cell segmentation based on phase contrast optics, Bio-Medical Materials and Engineering 24(1) (2014), 29–35. [5] Ikuo Yamamoto, Naohiro Inagawa, Miki Matsui, Kenji Hachisuka et al., Research and development of compact wrist rehabilitation robot system, Bio-Medical Materials and Engineering 24(1) (2014), 123–128. [6] Joanna Stasiak, Sukumaran Nair and Geoff Moggridge, Mechanical strength of sutured block copolymers films for load bearing medical applications, Bio-Medical Materials and Engineering 24(1) (2014), 563–569. [7] Min Wang, Yingyuan Ning, Haixiao Zou, Si Chen et al., Effect of Nd:YAG laser nitriding-treated titanium nitride surface of Ti6Al4V substrate on the activity of MC3T3-E1 cells, Bio-Medical Materials and Engineering 24(1) (2014), 643–649. [8] Guangping Lia, Hongfa Yangc, Wenxue Lia, Shanshan Qu et al., Transcriptional suppression of human apolipoprotein A4 and apolipoprote in C3 genes by phorbol myristate acetate in hepatic and intestinal cells, Bio-Medical Materials and Engineering 24(1) (2014), 877–884. [9] Wenwei Tang, Min Zhang and Xinping Zeng, Establishment of dsDNA/GNs/chit/GCE biosensor and electrochemical study on interaction between 6-mercaptopurine and DNA, Bio-Medical Materials and Engineering 24(1) (2014), 1071– 1077. [10] Shanshan Wang, Yong Xia, Pei Dong, Jianhua Luo et al., Bias correction for magnetic resonance images via joint entropy regularization, Bio-Medical Materials and Engineering 24(1) (2014), 1239–1245.
Copyright of Bio-Medical Materials & Engineering is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
3
Guest-editorial
Frontiers in Biomedical Engineering and Biotechnology Feng Liu a,* , Ali Goodarzi b , Haifeng Wang c , Joanna Stasiak d , Jianbo Sun e and Yu Zhou f a International
School of Software, Wuhan University, No. 37 Luoyu Road, Wuhan, 430070, China Medical School, Harvard University, 25 Shattuck Street, Boston, MA 02115, USA c Department of Diagnostic Radiology, Yale University, 5 Sheldon Terrace, New Haven, CT 06511, USA d Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK e Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, USA f Inspirees International in The Netherlands, The Netherlands b Harvard
Abstract. The 2nd International Conference on Biomedical Engineering and Biotechnology (iCBEB 2013), held in Wuhan on 11–13 October 2013, is an annual conference that aims at providing an opportunity for international and national researchers and practitioners to present the most recent advances and future challenges in the fields of Biomedical Information, Biomedical Engineering and Biotechnology. The papers published by this issue are selected from this conference, which witnesses the frontier in the field of Biomedical Engineering and Biotechnology, which particularly has helped improving the level of clinical diagnosis in medical work. Keywords: Biomedical engineering, iCBEB
1. Introduction Health problem is a key problem in human being, which prompts more and more scientists and engineers get involved in this field. To improve the accuracy of diagnosis, new methods and advanced technology are applied to assist clinical diagnosis and biological experiments. To provide a good platform for researchers and experts to communicate, the 2nd International Conference on Biomedical Engineering and Biotechnology (iCBEB 2013) is held on 11–13 October 2013 in Wuhan [1]. The iCBEB 2013 is an international conference held annually that aims at providing an opportunity for international *
Corresponding author. E-mail: [email protected].
0959-2989/14/$27.50 © 2014 – IOS Press and the authors. All rights reserved
4
F. Liu et al. / Frontiers in Biomedical Engineering and Biotechnology
and national researchers and practitioners to present their most recent studies in the fields of Biomedical Information, Biomedical Engineering and Biotechnology. The first conference was held on 28th to 30th May 2012 in Macau, which was technically sponsored by University of Macau and IEEE [1]. In 2013, the conference mainly includes 7 tracks: Biomechanical Engineering, Biomedical Engineering, Biomaterials, Biotechnology, Biosensors and Bio-signal Processing, Biomedical imaging, and Bioinformatics.
2. Highlighted papers Recommended by the conference committees and reviewers, some papers are highlighted as follow. 2.1. Biomechanical engineering The paper New clinical failure mode triggered by a new coronary stent design proposes a computational LSC model using finite element analysis. Simulation results show that the connector number plays the most significant role in the development of the LSC issue [2]. Results show the LSC could be improved by up to 30% when the design pattern changes from the offset peak-to-peak design (Element) to the peak-to-peak design (Endeavor). The paper Mucoadhesive polymer films for tissue retraction in laparoscopic surgery: Ex-vivo study on their mechanical properties concludes that adhesive polymers can stick to the serosal side of the bowel with an adhesive force, which is sufficient to lift the bowel, providing a lower retraction stress than that caused by laparoscopic grasping which induces high localized pressures on the tissue [3]. 2.2. Biomedical engineering The paper Interactive Cell Segmentation based on Phase Contrast Optics proposes an interactive cell segmentation scheme over phase retardation features. Experimental results demonstrate that cells with different optical properties are well segmented via the proposed approach [4]. The paper Research and Development of Compact Wrist Rehabilitation Robot System develops the compact rehabilitation robot system which can support movement of the wrist of patients [5]. The robot system can detect and analyze the patient’s intention to move the wrist by such a biological signal as muscle potential, then, assist the wrist exercise of patients. 2.3. Biomaterials The paper Mechanical strength of sutured block copolymers films for load bearing medical applications studies the mechanical behavior of three styrenic thermoplastic block copolymer elastomers with applied surgical sutures [6]. The authors observe the distinct macroscopic deformation mechanisms upon stretching of samples with vertical and horizontal orientation. The paper Effect of Nd:YAG laser nitriding-treated titanium nitride surface of Ti6Al4V substrate on the activity of MC3T3-E1 cells reports results that the TiN surface formed by Nd:YAG laser nitriding is favorable for the proliferation and differentiation of MC3T3-E1 cells, which may allow them to be utilized for implant surface modification [7].
F. Liu et al. / Frontiers in Biomedical Engineering and Biotechnology
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2.4. Biotechnology The paper Transcriptional Suppression of Human Apolipoprotein A4 and Apolipoprotein C3 Genes by Phorbol Myristate Acetate in Hepatic and Intestinal Cells achieves results that PMA specifically down regulates the transcription of apoA4 and apoC3, but exhibits no effects on apoA1 or apoA5 in either HepG2 or Caco-2 cells. The suppressive effect of PMA on apoA4 and apoC3 results from its regulation of the transcription rate of the two genes [8]. The authors concludes that PMA down-regulates the transcription of apoA4 and apoC3 possibly through the common regulatory element shared by these two genes, suggesting a suppressive role of PKC on the transcriptional regulation of specific apo lipoproteins in hepatic and intestinal cells. 2.5. Biosensors and bio-signal processing The paper Establishment of dsDNA/GNs/chit/GCE biosensor and electrochemical study on interaction between 6-mercaptopurine and DNA gives the results that, after the modification of GNs-chit, the electrode activation area of GNs/chit/GCE increases remarkably, which is improved from 1.76 cm2 to 8.64 cm2 , and the responsive oxidation peak current of GNs/chit/GCE to K3 [Fe(CN)6 ] also increases remarkably. Meanwhile the research also demonstrates that DNA is effectively fixed on the GNs/chit/GCE electrode; 6-MP causes obvious damage to dsDNA, and the damage degree on the adenine is bigger than that on the guanine; the interaction between 6-MP and dsDNA is preliminarily deduced as the intercalation, and its electrochemical oxidation process is an irreversible process controlled by the adsorption [9]. 2.6. Biomedical imaging The paper Bias Correction for Magnetic Resonance Images via Joint Entropy Regularization exploits the spatial and gradient features of the corrupted MR images for bias correction via the joint entropy regularization and proposes two nonparametric bias correction algorithms namely IsoTVBiasC and AniTVBiasC. The test results show that the proposed two methods can effectively remove the bias field [10].
Acknowledgements We are grateful to conference committee members of iCBEB 2013 for their support and guidance. We would like to thank the anonymous reviewers including most TPC members for their careful review of the full papers. We would like to particularly thank Tomasz Dlugosz from Wroclaw University of Technology in Poland, Yiyun Cheng from East China Normal University in China, Peng Li from Shandong University in China, Chung-Yuan Chen from Sitronix Technology Corp., Sadreddin Baharnezhad from Islamic Azad University South Tehran, Joung Hwan from Sungkyunkwan University in South Korea, Asaduzzaman Khan from Central South University in China, Wei Li from the Second Military Medical University in China. They have viewed dozens of manuscripts for this conference. Additionally, special thanks are given to Prof. Dongsheng Liu from Tsinghua University, Prof. Ng Yin Kwee from Nanyang Technological University, Dr. Tomasz Długosz, from Wroclaw University of Technology, Dr. Yu Zhou from Inspirees International in The Netherlands, Maarten Fröhlich from IOS Press for their special contributions to this conference. All the great efforts from above people have made this conference successful.
6
F. Liu et al. / Frontiers in Biomedical Engineering and Biotechnology
References [1] iCBEB, International Conference on Biomedical Engineering and Biotechnology, http://www.icbeb.org. [2] Hao-Ming Hsiao, Chun-Ting Yeh, Yi-Hsiang Chiu, Chun Wang and Chun-Pei Chen, New clinical failure mode triggered by a new coronary stent design, Bio-Medical Materials and Engineering 24(1) (2014), 37–43. [3] Zhigang Wang, Lik-Ren Tai, Donald McLean, Emma J. Wright et al., Mucoadhesive polymer films for tissue retraction in laparoscopic surgery: Ex-vivo study on their mechanical properties, Bio-Medical Materials and Engineering 24(1) (2014), 445–451. [4] Hang Su, Zhou Su, Shibao Zheng, Hua Yang and Sha Wei, Interactive cell segmentation based on phase contrast optics, Bio-Medical Materials and Engineering 24(1) (2014), 29–35. [5] Ikuo Yamamoto, Naohiro Inagawa, Miki Matsui, Kenji Hachisuka et al., Research and development of compact wrist rehabilitation robot system, Bio-Medical Materials and Engineering 24(1) (2014), 123–128. [6] Joanna Stasiak, Sukumaran Nair and Geoff Moggridge, Mechanical strength of sutured block copolymers films for load bearing medical applications, Bio-Medical Materials and Engineering 24(1) (2014), 563–569. [7] Min Wang, Yingyuan Ning, Haixiao Zou, Si Chen et al., Effect of Nd:YAG laser nitriding-treated titanium nitride surface of Ti6Al4V substrate on the activity of MC3T3-E1 cells, Bio-Medical Materials and Engineering 24(1) (2014), 643–649. [8] Guangping Lia, Hongfa Yangc, Wenxue Lia, Shanshan Qu et al., Transcriptional suppression of human apolipoprotein A4 and apolipoprote in C3 genes by phorbol myristate acetate in hepatic and intestinal cells, Bio-Medical Materials and Engineering 24(1) (2014), 877–884. [9] Wenwei Tang, Min Zhang and Xinping Zeng, Establishment of dsDNA/GNs/chit/GCE biosensor and electrochemical study on interaction between 6-mercaptopurine and DNA, Bio-Medical Materials and Engineering 24(1) (2014), 1071– 1077. [10] Shanshan Wang, Yong Xia, Pei Dong, Jianhua Luo et al., Bias correction for magnetic resonance images via joint entropy regularization, Bio-Medical Materials and Engineering 24(1) (2014), 1239–1245.
Copyright of Bio-Medical Materials & Engineering is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
