International Journal of Pharmaceutics xxx (xxxx) xxx–xxx
Contents lists available at ScienceDirect
International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm
Preface
From smart materials to advanced drug delivery systems
This special issue of International Journal of Pharmaceutics entitled From Smart Materials to Advanced Drug Delivery Systems arises as a result of scientific efforts connected with 11th Central European Symposium on Pharmaceutical Technology which was organized by the Faculty of Pharmacy, University of Belgrade, Serbia from 22nd to 24th September 2016 with Prof. S. Ibrić as Chair and Prof. A. Mrhar as Co-Chair. Under the European Federation of Pharmaceutical Sciences as the main patron association, leading researchers in the area from 30 countries presented a total of 2 plenary lectures, 9 invited lectures, 25 oral and 121 poster presentations with the aim to show recent advances in drug formulation, pharmaceutical engineering, in vitro/in vivo/in silico modeling and pharmaceutical regulatory sciences. The most outstanding symposium presentations were selected and the authors were invited to prepare full length papers to be included in this issue of International Journal of Pharmaceutics. The papers collected in this special issue are focused mainly on smart materials and up-to- date techniques for formulation and evaluation of advanced drug delivery systems. Production of nanocrystals by wet media milling, preparation and characterization of new soluble and bioactive polymorphs of the selected drug substances, mechanical activation of active pharmaceutical ingredients to enhance solubility, study of technological properties and aerodynamic behaviour of spray-dried powders, mucoadhesive buccal gels containing lipid nanoparticles, lipid/alginate nanoparticles for nasal delivery of steroids, 3D printed orodispersible films with BCS Class II drug substance, nanoemulsions as promising carriers for parenteral delivery of poorlysoluble centrally-acting drugs, study of water content influence on microstructure of liquid crystals as dermal delivery system, self micro/nanoemulsyfying drug delivery systems to solve low bioavaliability issues, implantable matrices from degradable and non-degradable polymers, and tastemasking multiparticulate dosage forms are cases which support thoroughly the title topic of this special issue. Moreover, there are some contributions where efficacy was assessed by an in vivo experimental model to show how nanoparticles affect interface interactions, biodistribution, internalization and gene expression, where miscibility between drug and polymer can be measured effectively by the use of solubility and Flory-Huggins interaction parameters, and how to elucidate drug release mechanisms from solid dosage forms by visualization using confocal Raman microscopy. Finnaly, different aspects of modelling and computer simulation are presented in several contributions, like those used in the context of QbD, in drug transport (by showing effects of transdermal iontophoresis on the electrotransport of drug substance across the buccal tissue and skin), and in analysis of pellet coating uniformity using a computer scanner. Overall, the contents of this issue show the solutions for some challenges in modern pharmaceutical development. At the same time, many questions still remain to be solved. However, some of them will lead to further, even more intensive and exciting research. At last, we wish to thank Prof. A.T. Florence and Elsevier for giving the opportunity to show by this issue of International Journal of Pharmaceutics recent achievements in the field of drug delivery systems. We also want to thank the authors of the papers, as without their contribution this issue would not be available to those who are interested in the progress of this fast growing scientific area. ⁎
Svetlana Ibrić , Jelena Parojčić, Aleš Mrhar University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221 Beograd, Serbia University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia E-mail address: [email protected]
⁎
Corresponding author.
http://dx.doi.org/10.1016/j.ijpharm.2017.08.105
0378-5173/ © 2017 Published by Elsevier B.V.
Contents lists available at ScienceDirect
International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm
Preface
From smart materials to advanced drug delivery systems
This special issue of International Journal of Pharmaceutics entitled From Smart Materials to Advanced Drug Delivery Systems arises as a result of scientific efforts connected with 11th Central European Symposium on Pharmaceutical Technology which was organized by the Faculty of Pharmacy, University of Belgrade, Serbia from 22nd to 24th September 2016 with Prof. S. Ibrić as Chair and Prof. A. Mrhar as Co-Chair. Under the European Federation of Pharmaceutical Sciences as the main patron association, leading researchers in the area from 30 countries presented a total of 2 plenary lectures, 9 invited lectures, 25 oral and 121 poster presentations with the aim to show recent advances in drug formulation, pharmaceutical engineering, in vitro/in vivo/in silico modeling and pharmaceutical regulatory sciences. The most outstanding symposium presentations were selected and the authors were invited to prepare full length papers to be included in this issue of International Journal of Pharmaceutics. The papers collected in this special issue are focused mainly on smart materials and up-to- date techniques for formulation and evaluation of advanced drug delivery systems. Production of nanocrystals by wet media milling, preparation and characterization of new soluble and bioactive polymorphs of the selected drug substances, mechanical activation of active pharmaceutical ingredients to enhance solubility, study of technological properties and aerodynamic behaviour of spray-dried powders, mucoadhesive buccal gels containing lipid nanoparticles, lipid/alginate nanoparticles for nasal delivery of steroids, 3D printed orodispersible films with BCS Class II drug substance, nanoemulsions as promising carriers for parenteral delivery of poorlysoluble centrally-acting drugs, study of water content influence on microstructure of liquid crystals as dermal delivery system, self micro/nanoemulsyfying drug delivery systems to solve low bioavaliability issues, implantable matrices from degradable and non-degradable polymers, and tastemasking multiparticulate dosage forms are cases which support thoroughly the title topic of this special issue. Moreover, there are some contributions where efficacy was assessed by an in vivo experimental model to show how nanoparticles affect interface interactions, biodistribution, internalization and gene expression, where miscibility between drug and polymer can be measured effectively by the use of solubility and Flory-Huggins interaction parameters, and how to elucidate drug release mechanisms from solid dosage forms by visualization using confocal Raman microscopy. Finnaly, different aspects of modelling and computer simulation are presented in several contributions, like those used in the context of QbD, in drug transport (by showing effects of transdermal iontophoresis on the electrotransport of drug substance across the buccal tissue and skin), and in analysis of pellet coating uniformity using a computer scanner. Overall, the contents of this issue show the solutions for some challenges in modern pharmaceutical development. At the same time, many questions still remain to be solved. However, some of them will lead to further, even more intensive and exciting research. At last, we wish to thank Prof. A.T. Florence and Elsevier for giving the opportunity to show by this issue of International Journal of Pharmaceutics recent achievements in the field of drug delivery systems. We also want to thank the authors of the papers, as without their contribution this issue would not be available to those who are interested in the progress of this fast growing scientific area. ⁎
Svetlana Ibrić , Jelena Parojčić, Aleš Mrhar University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221 Beograd, Serbia University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia E-mail address: [email protected]
⁎
Corresponding author.
http://dx.doi.org/10.1016/j.ijpharm.2017.08.105
0378-5173/ © 2017 Published by Elsevier B.V.
