CORRIGENDUM
FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer Lingfeng He, Libo Luo, Hong Zhu, Huan Yang, Yilan Zhang, Huan Wu, Hongfang Sun, Feng Jiang, Chandra S. Kathera, Lingjie Liu, Ziheng Zhuang, Haoyan Chen, Feiyan Pan, Zhigang Hu, Jing Zhang and Zhigang Guo Volume 11, Issue 6, pages 640–654. First published: 12 May 2017 The authors of this article have supplied the following correction. Figure 1E was mistakenly replaced by Fig. 1G of He et al. (2016) during the final assembly of the figures for review. The corrected figure is provided below. The authors apologize for the error.
Normalized mRNA expression of FEN1
11 10 9
Tumor
8
C 100
Normal
D
Normal Tumor
** 75 50 25
Spearman correlation test P = 0.021
2
**
FEN1 expression
Lung cancer
Patient number (%)
FEN1 staining
B Normal
A
1
0
–1
0 < 100
100–200
> 200
FEN1 score
II
III
IV
AJCC stages
FEN1
E Survival probability (%)
I
100
Low
80 60
High
40 20 0
Log rank P = 3.44 e-6 HR = 7.18 (2.53–20.35) 0 14 28 42 56 70 84 98 112 126
Time (month)
1302
Molecular Oncology 11 (2017) 1302–1303 ª 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Corrigendum
Fig. 1. FEN1 overexpression was associated with lung cancer. (A) FEN1 expression analysis based on TCGA dataset showed that FEN1 mRNA levels were higher in lung cancer tissue than in normal tissue (*P < 0.01 vs control group). (B) FEN1 displayed significantly stronger staining (brown) in tumor specimens from clinical patients than from healthy counterparts. Immunohistochemistry was performed on formalin-fixed and paraffin-embedded tissues using antibodies against FEN1. Original magnification, 9400. Scale bars, 250 lm. (C). Number of patients’ samples with FEN1 score > 200 was significantly higher in tumors than in normal tissues (**P < 0.01 vs control group). (D) FEN1 expression was correlated with the clinical stage of lung cancer. Spearman’s correlation test, P = 0.021. (E) Kaplan–Meier analysis of survival of patients with lung cancer. Log rank P = 3.44 e-6.
References He L, Zhang Y, Sun H, Jiang F, Yang H, Wu H, Zhou T, Hu S, Sekhar Kathera C, Wang X et al. (2016)
Targeting DNA flap endonuclease 1 to impede breast cancer progression. EBioMedicine 14, 32–43.
Molecular Oncology 11 (2017) 1302–1303 ª 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
1303