RESEARCH

ARTICLE CME

Female Reproductive Factors, Menopausal Hormone Use, and Parkinson’s Disease Rui Liu, PhD,1 Donna Baird, PhD,1 Yikyung Park, ScD,2 Neal D. Freedman, PhD,2 Xuemei Huang, MD, PhD,3 Albert Hollenbeck, PhD,4 Aaron Blair, PhD,2 and Honglei Chen, MD, PhD1* 1

Epidemiology Branch of the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 3 Departments of Neurology, Pennsylvania State University—Milton S. Hershey Medical Center, Hershey, Pennsylvania 4 AARP, Washington, DC

ABSTRACT:

The objective of this study was to examine the associations of reproductive factors and exogenous hormone use with risk of Parkinson’s disease (PD) among postmenopausal women. The study comprised 119,166 postmenopausal women aged 50 to 71 years in the NIH-AARP Diet and Health Study, who completed a baseline questionnaire in 1995–1996 and a follow-up survey in 2004–2006. A total of 410 selfreported PD diagnoses were identified between 1995 and 2006. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were derived from logistic regression models. PD risk was not significantly associated with female reproductive factors including age at menarche, age at first live birth, parity, and age at menopause. For example, compared with women with natural menopause at age 50 to 54 years, the ORs were 1.18, (95% CI, 0.78-1.79) for women with natural menopause aged

Female reproductive factors, menopausal hormone use, and Parkinson's disease.

The objective of this study was to examine the associations of reproductive factors and exogenous hormone use with risk of Parkinson's disease (PD) am...
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