ARTICLE IN PRESS Cancer Letters ■■ (2015) ■■–■■
Contents lists available at ScienceDirect
Cancer Letters j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / c a n l e t
Special Issue Editorial
Featuring the guest editor: Special issue tumor microenvironment
Dr. Shree Ram Singh is a Staff Scientist in the Stem Cell Regulation and Animal Aging Section of Basic Research Laboratory at National Cancer Institute, Frederick, Maryland, USA. He received a Ph.D. in genetics from Banaras Hindu University, India. Dr. Singh was a guest scientist and a UNESCO Biotechnology Action Council (BAC) fellow at Johann Wolfgang Goethe University, Frankfurt, Germany. Dr. Singh performed postdoctoral studies at the University of Haifa, Israel and at the National Cancer Institute, USA. Dr. Singh’s research is focused on stem cell biology and cancer research. Specifically, utilizing the adult testis, kidney and gastrointestinal tissues, he is investigating the molecular genetic mechanisms by which stem cells regulate tissue homeostasis, regeneration, and tumorigenesis. His other interests include cancer stem cells and tumor microenvironment, microRNAs and hypoxia inducible factors in tumor metabolism. Dr. Singh received numerous fellowships and grants. Dr. Singh has authored >75 publications, which include original articles, reviews, editorials, books, and book chapters. Some of his seminal research findings have been published in high impact journals such as Cell Stem Cell, Developmental Cell, Cell Reports, Oncogene, and Cancer Letters. In addition, he has edited seven books in stem cells and cancer research field. Dr. Singh has also served as a Guest Editor for several special issues on the topic related to stem cells, cancer stem cells, and cancer metabolism. Dr. Singh is an Academic Editor of PLOS ONE, Associate Editor in BMC Genetics, and editorial board member of several journals including Cancer Letters and Frontiers in Cell and Developmental Biology. Dr. Singh is a regular reviewer of several highimpact journals in the field of stem cell biology and cancer research. He has also served in national and international advisory board/ review panels. Dr. Singh has trained several Postdoctoral fellows, student interns, and Postbaccalaureate Fellows, and serves as a member of Graduate Advisory Committee. Dr. Singh has been invited to present his research findings in numerous national and international meetings.
Dr. Rameshwar is a professor of medicine in the Division of Hematology and Oncology at New Jersey Medical School (NJMS), Rutgers. She received a B.S. degree in medical microbiology from the University of Wisconsin at Madison and a Ph.D. in biology from Rutgers University, New Jersey. Dr. Rameshwar performed postdoctoral studies in hematopoiesis at New Jersey Medical School. She started as a faculty member at New Jersey Medical School in 1995. Dr. Rameshwar’s research interest is in stem cell biology. Her laboratory also studies breast cancer dormancy with a focus on cancer stem cells; neural regulation of hematopoiesis, the immunology of adult human mesenchymal stem cells, and clinical application of mesenchymal stem cells. Her research continues to be funded by federal, state, and other agencies. Dr. Rameshwar has trained several doctoral students, including those in the physician scientist track. In addition, Dr. Rameshwar mentors junior faculty members. Dr. Rameshwar has authored >190 publications, which include original articles, reviews, editorials and book chapters. She has also edited books. Dr. Rameshwar is also involved in teaching. She initiated a certificate program in Stem Cell Biology and directs four graduate level courses in stem cell biology. Dr. Rameshwar is also a university Master Educator. Dr. Rameshwar is the editor and on the editorial board of several journals. Dr. Rameshwar also serves on several grant review panels both nationally and internationally. She has given numerous invited seminars both nationally and internationally.
http://dx.doi.org/10.1016/j.canlet.2015.05.021 0304-3835/Published by Elsevier Ireland Ltd.
Please cite this article in press as: Shree Ram Singh, Pranela Rameshwar, Peter Siegel, Featuring the guest editor: Special issue tumor microenvironment, Cancer Letters (2015), doi: 10.1016/j.canlet.2015.05.021
ARTICLE IN PRESS 2
Special Issue Editorial/Cancer Letters ■■ (2015) ■■–■■
Dr. Siegel received his B.Sc. degree (1988–1992) from the Department of Biology at McMaster University in Hamilton, Ontario. He subsequently pursued his Ph.D. degree (1992–1999) at the same institute under the supervision of Dr. William J. Muller, where he studied mechanisms controlling the oncogenic activation of the ErbB2 receptor in breast cancer using transgenic mouse models. Dr. Siegel conducted his post-doctoral training (1999–2003) in Dr. Joan Massague’s laboratory at the Memorial Sloan Kettering Cancer Centre in New York City. During this time, he investigated the interplay between the ErbB2 receptor and TGFβ signaling pathways during tumor progression and metastasis. He also began to investigate the molecular determinants of breast cancer metastasis to specific organs and tissues. Dr. Siegel joined the Department of Medicine at McGill University as an Assistant Professor in 2004 and he is currently an Associate Professor in the Department of Medicine at McGill University and a full member of the Goodman Cancer Research Centre. Dr. Siegel served as Interim Director for the Goodman Cancer Research Centre (2012–2013) and currently serves as its Associate Director (2013–present). Dr. Siegel is currently a member of the Institute of Cancer advisory board for the Canadian Institutes of Health Research. Dr. Siegel’s research focuses on the fundamental mechanisms that control organ-selective breast cancer metastasis and employs preclinical animal models and clinical material to identify molecular mediators and cellular processes that promote breast cancer
metastasis to distinct sites such as the bone, lung, and liver. His laboratory also evaluates experimental therapeutic agents against clinically and functionally validated targets that modulate the metastatic behavior of breast cancer cells. Dr. Siegel is the past recipient of a Damon Runyon–Walter Winchell Post-doctoral fellowship. Since the beginning of his independent research career, he has been the recipient of the Harold E. Johns Award from the Canadian Cancer Society (2004–2010), was named a research Scholar of the FRSQ (2010–2012), and is currently a William Dawson Scholar of McGill University (2014–present). His research has been funded by both national and international funding agencies, including: the Canadian Institutes of Health Research, Canadian Cancer Society Research Institute, Terry Fox Foundation, Prostate Cancer Canada, the Cancer Research Society, the US Department of Defense, and the International Association of Cancer Research. Shree Ram Singh * Stem Cell Regulation and Animal Aging Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA * Tel.: +1 301 846 7331. E-mail address: [email protected] Pranela Rameshwar ** Division of Hematology and Oncology, New Jersey Medical School (NJMS)-Rutgers, Newark, NJ 07103, USA ** Tel.: +1 973 972 4913. E-mail address: [email protected] Peter Siegel *** Department of Medicine, Biochemistry, Anatomy & Cell Biology and Oncology, Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada *** Tel.: +1 514 398 4259. E-mail address: [email protected]
Please cite this article in press as: Shree Ram Singh, Pranela Rameshwar, Peter Siegel, Featuring the guest editor: Special issue tumor microenvironment, Cancer Letters (2015), doi: 10.1016/j.canlet.2015.05.021
Contents lists available at ScienceDirect
Cancer Letters j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / c a n l e t
Special Issue Editorial
Featuring the guest editor: Special issue tumor microenvironment
Dr. Shree Ram Singh is a Staff Scientist in the Stem Cell Regulation and Animal Aging Section of Basic Research Laboratory at National Cancer Institute, Frederick, Maryland, USA. He received a Ph.D. in genetics from Banaras Hindu University, India. Dr. Singh was a guest scientist and a UNESCO Biotechnology Action Council (BAC) fellow at Johann Wolfgang Goethe University, Frankfurt, Germany. Dr. Singh performed postdoctoral studies at the University of Haifa, Israel and at the National Cancer Institute, USA. Dr. Singh’s research is focused on stem cell biology and cancer research. Specifically, utilizing the adult testis, kidney and gastrointestinal tissues, he is investigating the molecular genetic mechanisms by which stem cells regulate tissue homeostasis, regeneration, and tumorigenesis. His other interests include cancer stem cells and tumor microenvironment, microRNAs and hypoxia inducible factors in tumor metabolism. Dr. Singh received numerous fellowships and grants. Dr. Singh has authored >75 publications, which include original articles, reviews, editorials, books, and book chapters. Some of his seminal research findings have been published in high impact journals such as Cell Stem Cell, Developmental Cell, Cell Reports, Oncogene, and Cancer Letters. In addition, he has edited seven books in stem cells and cancer research field. Dr. Singh has also served as a Guest Editor for several special issues on the topic related to stem cells, cancer stem cells, and cancer metabolism. Dr. Singh is an Academic Editor of PLOS ONE, Associate Editor in BMC Genetics, and editorial board member of several journals including Cancer Letters and Frontiers in Cell and Developmental Biology. Dr. Singh is a regular reviewer of several highimpact journals in the field of stem cell biology and cancer research. He has also served in national and international advisory board/ review panels. Dr. Singh has trained several Postdoctoral fellows, student interns, and Postbaccalaureate Fellows, and serves as a member of Graduate Advisory Committee. Dr. Singh has been invited to present his research findings in numerous national and international meetings.
Dr. Rameshwar is a professor of medicine in the Division of Hematology and Oncology at New Jersey Medical School (NJMS), Rutgers. She received a B.S. degree in medical microbiology from the University of Wisconsin at Madison and a Ph.D. in biology from Rutgers University, New Jersey. Dr. Rameshwar performed postdoctoral studies in hematopoiesis at New Jersey Medical School. She started as a faculty member at New Jersey Medical School in 1995. Dr. Rameshwar’s research interest is in stem cell biology. Her laboratory also studies breast cancer dormancy with a focus on cancer stem cells; neural regulation of hematopoiesis, the immunology of adult human mesenchymal stem cells, and clinical application of mesenchymal stem cells. Her research continues to be funded by federal, state, and other agencies. Dr. Rameshwar has trained several doctoral students, including those in the physician scientist track. In addition, Dr. Rameshwar mentors junior faculty members. Dr. Rameshwar has authored >190 publications, which include original articles, reviews, editorials and book chapters. She has also edited books. Dr. Rameshwar is also involved in teaching. She initiated a certificate program in Stem Cell Biology and directs four graduate level courses in stem cell biology. Dr. Rameshwar is also a university Master Educator. Dr. Rameshwar is the editor and on the editorial board of several journals. Dr. Rameshwar also serves on several grant review panels both nationally and internationally. She has given numerous invited seminars both nationally and internationally.
http://dx.doi.org/10.1016/j.canlet.2015.05.021 0304-3835/Published by Elsevier Ireland Ltd.
Please cite this article in press as: Shree Ram Singh, Pranela Rameshwar, Peter Siegel, Featuring the guest editor: Special issue tumor microenvironment, Cancer Letters (2015), doi: 10.1016/j.canlet.2015.05.021
ARTICLE IN PRESS 2
Special Issue Editorial/Cancer Letters ■■ (2015) ■■–■■
Dr. Siegel received his B.Sc. degree (1988–1992) from the Department of Biology at McMaster University in Hamilton, Ontario. He subsequently pursued his Ph.D. degree (1992–1999) at the same institute under the supervision of Dr. William J. Muller, where he studied mechanisms controlling the oncogenic activation of the ErbB2 receptor in breast cancer using transgenic mouse models. Dr. Siegel conducted his post-doctoral training (1999–2003) in Dr. Joan Massague’s laboratory at the Memorial Sloan Kettering Cancer Centre in New York City. During this time, he investigated the interplay between the ErbB2 receptor and TGFβ signaling pathways during tumor progression and metastasis. He also began to investigate the molecular determinants of breast cancer metastasis to specific organs and tissues. Dr. Siegel joined the Department of Medicine at McGill University as an Assistant Professor in 2004 and he is currently an Associate Professor in the Department of Medicine at McGill University and a full member of the Goodman Cancer Research Centre. Dr. Siegel served as Interim Director for the Goodman Cancer Research Centre (2012–2013) and currently serves as its Associate Director (2013–present). Dr. Siegel is currently a member of the Institute of Cancer advisory board for the Canadian Institutes of Health Research. Dr. Siegel’s research focuses on the fundamental mechanisms that control organ-selective breast cancer metastasis and employs preclinical animal models and clinical material to identify molecular mediators and cellular processes that promote breast cancer
metastasis to distinct sites such as the bone, lung, and liver. His laboratory also evaluates experimental therapeutic agents against clinically and functionally validated targets that modulate the metastatic behavior of breast cancer cells. Dr. Siegel is the past recipient of a Damon Runyon–Walter Winchell Post-doctoral fellowship. Since the beginning of his independent research career, he has been the recipient of the Harold E. Johns Award from the Canadian Cancer Society (2004–2010), was named a research Scholar of the FRSQ (2010–2012), and is currently a William Dawson Scholar of McGill University (2014–present). His research has been funded by both national and international funding agencies, including: the Canadian Institutes of Health Research, Canadian Cancer Society Research Institute, Terry Fox Foundation, Prostate Cancer Canada, the Cancer Research Society, the US Department of Defense, and the International Association of Cancer Research. Shree Ram Singh * Stem Cell Regulation and Animal Aging Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA * Tel.: +1 301 846 7331. E-mail address: [email protected] Pranela Rameshwar ** Division of Hematology and Oncology, New Jersey Medical School (NJMS)-Rutgers, Newark, NJ 07103, USA ** Tel.: +1 973 972 4913. E-mail address: [email protected] Peter Siegel *** Department of Medicine, Biochemistry, Anatomy & Cell Biology and Oncology, Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada *** Tel.: +1 514 398 4259. E-mail address: [email protected]
Please cite this article in press as: Shree Ram Singh, Pranela Rameshwar, Peter Siegel, Featuring the guest editor: Special issue tumor microenvironment, Cancer Letters (2015), doi: 10.1016/j.canlet.2015.05.021
