Clinical Practice: Original Paper Received: February 17, 2015 Accepted after revision: April 20, 2015 Published online: May 27, 2015
Nephron 2015;130:113–118 DOI: 10.1159/000430827
Fatigue Is Associated with Increased Risk of Mortality in Patients on Chronic Hemodialysis Maurizio Bossola a Enrico Di Stasio b Manuela Antocicco c Loredana Panico d Gilda Pepe a Luigi Tazza a
a
Hemodialysis Service, Department of Surgery, b Department of Clinical Chemistry, c Department of Gerontology, Geriatrics and Psychiatry and d Department of Public Health, Catholic University of the Sacred Heart, Rome, Italy
Abstract Background: Little is known about the correlation between fatigue and survival in patients on chronic hemodialysis and whether fatigue is an independent predictor of outcome above and beyond the effects of depression. The aim of the present study was to determine if fatigue is a predictor of mortality in patients on chronic hemodialysis (CHP) and if this occurs independently of the symptoms of depression. Methods: CHP referring to the Hemodialysis Service of the Università Cattolica of Rome, Italy between November 2007 and January 2015 were studied. Demographic, clinical, and laboratory data were recorded for each patient at the moment of the inclusion in the study. Fatigue levels were assessed in patients using the Vitality Scale of SF-36 (SF-36 VS), functional ability by the activities of daily living (ADL) and instrumental activities of daily living (IADL), depressive symptoms through the Geriatric Depression Scale (GDS), cognitive function using the Mini Mental State Examination (MMSE), and comorbidity through the Charlson Comorbidity
© 2015 S. Karger AG, Basel 1660–8151/15/1302–0113$39.50/0 E-Mail [email protected] www.karger.com/nef
Index (CCI). Patients were grouped into four groups (quartiles): Quartile 1 (Q1), >65; Q2, ≥50 to
Nephron 2015;130:113–118 DOI: 10.1159/000430827
Fatigue Is Associated with Increased Risk of Mortality in Patients on Chronic Hemodialysis Maurizio Bossola a Enrico Di Stasio b Manuela Antocicco c Loredana Panico d Gilda Pepe a Luigi Tazza a
a
Hemodialysis Service, Department of Surgery, b Department of Clinical Chemistry, c Department of Gerontology, Geriatrics and Psychiatry and d Department of Public Health, Catholic University of the Sacred Heart, Rome, Italy
Abstract Background: Little is known about the correlation between fatigue and survival in patients on chronic hemodialysis and whether fatigue is an independent predictor of outcome above and beyond the effects of depression. The aim of the present study was to determine if fatigue is a predictor of mortality in patients on chronic hemodialysis (CHP) and if this occurs independently of the symptoms of depression. Methods: CHP referring to the Hemodialysis Service of the Università Cattolica of Rome, Italy between November 2007 and January 2015 were studied. Demographic, clinical, and laboratory data were recorded for each patient at the moment of the inclusion in the study. Fatigue levels were assessed in patients using the Vitality Scale of SF-36 (SF-36 VS), functional ability by the activities of daily living (ADL) and instrumental activities of daily living (IADL), depressive symptoms through the Geriatric Depression Scale (GDS), cognitive function using the Mini Mental State Examination (MMSE), and comorbidity through the Charlson Comorbidity
© 2015 S. Karger AG, Basel 1660–8151/15/1302–0113$39.50/0 E-Mail [email protected] www.karger.com/nef
Index (CCI). Patients were grouped into four groups (quartiles): Quartile 1 (Q1), >65; Q2, ≥50 to
