The New England Journal of Medicine Downloaded from nejm.org at MCGILL UNIVERSITY LIBRARY on April 4, 2013. For personal use only. No other uses without permission. Copyright © 1992 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at MCGILL UNIVERSITY LIBRARY on April 4, 2013. For personal use only. No other uses without permission. Copyright © 1992 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at MCGILL UNIVERSITY LIBRARY on April 4, 2013. For personal use only. No other uses without permission. Copyright © 1992 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at MCGILL UNIVERSITY LIBRARY on April 4, 2013. For personal use only. No other uses without permission. Copyright © 1992 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at MCGILL UNIVERSITY LIBRARY on April 4, 2013. For personal use only. No other uses without permission. Copyright © 1992 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at MCGILL UNIVERSITY LIBRARY on April 4, 2013. For personal use only. No other uses without permission. Copyright © 1992 Massachusetts Medical Society. All rights reserved.

Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.

We previously described two members of a family affected by an apparently genetically determined fatal disease characterized clinically by progressive...
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