Atherosclerosis 237 (2014) 361e368
Contents lists available at ScienceDirect
Atherosclerosis journal homepage: www.elsevier.com/locate/atherosclerosis
Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: The Circulatory Risk in Communities Study (CIRCS) Hiroyasu Iso a, *, Hironori Imano a, b, Kazumasa Yamagishi c, Tetsuya Ohira a, b, Renzhe Cui a, Hiroyuki Noda a, Shinichi Sato d, Masahiko Kiyama b, Takeo Okada b, Shinichi Hitsumoto e, Takeshi Tanigawa f, Akihiko Kitamura b, for the CIRCS Investigators a
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan c Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan d Chiba Prefectural Institute of Public Health, Nitona Government Office Building, 666-2 Nitonacho, Chuo-ku, Chiba, 260-8715, Japan e Total Medical Support Center, Ehime University Hospital, 454 Shitsukawa, Toon, 791-0295, Japan f Department of Environmental Health and Social Medicine, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, 791-0295, Japan b
a r t i c l e i n f o
a b s t r a c t
Article history: Received 27 March 2014 Received in revised form 29 July 2014 Accepted 8 August 2014 Available online 6 September 2014
Background: Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. Methods: We used 1975e1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40e69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (8 h after meal) and 8235 non-fasting (
Contents lists available at ScienceDirect
Atherosclerosis journal homepage: www.elsevier.com/locate/atherosclerosis
Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: The Circulatory Risk in Communities Study (CIRCS) Hiroyasu Iso a, *, Hironori Imano a, b, Kazumasa Yamagishi c, Tetsuya Ohira a, b, Renzhe Cui a, Hiroyuki Noda a, Shinichi Sato d, Masahiko Kiyama b, Takeo Okada b, Shinichi Hitsumoto e, Takeshi Tanigawa f, Akihiko Kitamura b, for the CIRCS Investigators a
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-3-2 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan c Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan d Chiba Prefectural Institute of Public Health, Nitona Government Office Building, 666-2 Nitonacho, Chuo-ku, Chiba, 260-8715, Japan e Total Medical Support Center, Ehime University Hospital, 454 Shitsukawa, Toon, 791-0295, Japan f Department of Environmental Health and Social Medicine, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon, 791-0295, Japan b
a r t i c l e i n f o
a b s t r a c t
Article history: Received 27 March 2014 Received in revised form 29 July 2014 Accepted 8 August 2014 Available online 6 September 2014
Background: Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. Methods: We used 1975e1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40e69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (8 h after meal) and 8235 non-fasting (
