Original Paper Cerebrovasc Dis 2013;36:299–305 DOI: 10.1159/000355054
Received: May 2, 2013 Accepted: August 14, 2013 Published online: October 16, 2013
Factors Associated with Early Recanalization Failure following Intravenous rt-PA Therapy for Ischemic Stroke Masatoshi Koga a Shoji Arihiro a Fumio Miyashita b Haruko Yamamoto c Naoaki Yamada d Kazuyuki Nagatsuka e Kazuo Minematsu b Kazunori Toyoda b a
Division of Stroke Care Unit, b Department of Cerebrovascular Medicine, c Department of Advanced Medical Technology Development, Research and Development Initiative Center, d Department of Radiology and e Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan
Key Words Acute ischemic stroke · Intravenous thrombolysis · Recanalization · High-density lipoprotein cholesterol · C-reactive protein
Abstract Background: Although intravenous recombinant tissuetype plasminogen activator (rt-PA) therapy can be effective for ischemic stroke, a considerable percentage of patients do not receive any benefit as a result of early recanalization failure. We aimed to investigate the factors associated with early recanalization failure following intravenous rt-PA therapy. Methods: Patients with acute ischemic stroke and internal carotid artery (ICA) or middle cerebral artery occlusion on initial magnetic resonance angiography (MRA) who received intravenous rt-PA therapy within 3 h of stroke onset and underwent follow-up MRA within 8 h after treatment were enrolled. Baseline characteristics, stroke features, onset to treatment time, initial National Institutes of Health Stroke Scale (NIHSS) score, initial Alberta Stroke Programme Early CT Score on diffusion-weighted imaging-ASPECTS (Alberta Stroke Program Early Computed Tomography Score), the presence of ICA or M1 origin (the residual length
Received: May 2, 2013 Accepted: August 14, 2013 Published online: October 16, 2013
Factors Associated with Early Recanalization Failure following Intravenous rt-PA Therapy for Ischemic Stroke Masatoshi Koga a Shoji Arihiro a Fumio Miyashita b Haruko Yamamoto c Naoaki Yamada d Kazuyuki Nagatsuka e Kazuo Minematsu b Kazunori Toyoda b a
Division of Stroke Care Unit, b Department of Cerebrovascular Medicine, c Department of Advanced Medical Technology Development, Research and Development Initiative Center, d Department of Radiology and e Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan
Key Words Acute ischemic stroke · Intravenous thrombolysis · Recanalization · High-density lipoprotein cholesterol · C-reactive protein
Abstract Background: Although intravenous recombinant tissuetype plasminogen activator (rt-PA) therapy can be effective for ischemic stroke, a considerable percentage of patients do not receive any benefit as a result of early recanalization failure. We aimed to investigate the factors associated with early recanalization failure following intravenous rt-PA therapy. Methods: Patients with acute ischemic stroke and internal carotid artery (ICA) or middle cerebral artery occlusion on initial magnetic resonance angiography (MRA) who received intravenous rt-PA therapy within 3 h of stroke onset and underwent follow-up MRA within 8 h after treatment were enrolled. Baseline characteristics, stroke features, onset to treatment time, initial National Institutes of Health Stroke Scale (NIHSS) score, initial Alberta Stroke Programme Early CT Score on diffusion-weighted imaging-ASPECTS (Alberta Stroke Program Early Computed Tomography Score), the presence of ICA or M1 origin (the residual length
