MOLECULAR AND CLINICAL ONCOLOGY 5: 295-300, 2016
Expression of hypoxia-inducible factor-1α affects tumor proliferation and antiapoptosis in surgically resected lung cancer CHIHIRO TAKASAKI1, MASASHI KOBAYASHI1, HIRONORI ISHIBASHI1, TAKUMI AKASHI2 and KENICHI OKUBO1 Departments of 1Thoracic Surgery and 2Pathology, Tokyo Medical and Dental University, Tokyo 113‑0034, Japan Received March 15, 2016; Accepted May 26, 2016 DOI: 10.3892/mco.2016.937 Abstract. Hypoxia‑inducible factor (HIF)‑1 is a transcription factor that allows cells to adapt to hypoxic situations. HIF‑1 is known to control tissue proliferation, antiapoptosis, angiogenesis and glucose metabolism. Furthermore, HIF‑1 is involved in the growth of numerous cancer types. The present study aimed to examine the expression of HIF‑1α immunohistochemically in resected lung cancers. The present study included 216 consecutive patients with lung cancer who underwent resection between April 2013 and January 2015. The patients' clinicopathological data were summarized, including imaging findings, tumor pathological characteristics, and the patient's age, sex and smoking status. The intratumoral expression of HIF‑1α, survivin, c‑Myc and the Ki‑67 proliferation index were evaluated immunohistochemically. The patients were divided into two groups, according to the expression of HIF‑1α (low vs. high) and the clinicopathological characteristics of these groups were compared. It was revealed that HIF‑1α expression was significantly associated with ground glass opacity ratio, maximum standardized uptake value index, histological type (squamous cell carcinoma), differentiation and lymphatic invasion. Regarding the immunohistochemical findings, HIF‑1α expression was significantly correlated with the expression levels of c‑Myc (P
Expression of hypoxia-inducible factor-1α affects tumor proliferation and antiapoptosis in surgically resected lung cancer CHIHIRO TAKASAKI1, MASASHI KOBAYASHI1, HIRONORI ISHIBASHI1, TAKUMI AKASHI2 and KENICHI OKUBO1 Departments of 1Thoracic Surgery and 2Pathology, Tokyo Medical and Dental University, Tokyo 113‑0034, Japan Received March 15, 2016; Accepted May 26, 2016 DOI: 10.3892/mco.2016.937 Abstract. Hypoxia‑inducible factor (HIF)‑1 is a transcription factor that allows cells to adapt to hypoxic situations. HIF‑1 is known to control tissue proliferation, antiapoptosis, angiogenesis and glucose metabolism. Furthermore, HIF‑1 is involved in the growth of numerous cancer types. The present study aimed to examine the expression of HIF‑1α immunohistochemically in resected lung cancers. The present study included 216 consecutive patients with lung cancer who underwent resection between April 2013 and January 2015. The patients' clinicopathological data were summarized, including imaging findings, tumor pathological characteristics, and the patient's age, sex and smoking status. The intratumoral expression of HIF‑1α, survivin, c‑Myc and the Ki‑67 proliferation index were evaluated immunohistochemically. The patients were divided into two groups, according to the expression of HIF‑1α (low vs. high) and the clinicopathological characteristics of these groups were compared. It was revealed that HIF‑1α expression was significantly associated with ground glass opacity ratio, maximum standardized uptake value index, histological type (squamous cell carcinoma), differentiation and lymphatic invasion. Regarding the immunohistochemical findings, HIF‑1α expression was significantly correlated with the expression levels of c‑Myc (P
