Int J Clin Exp Med 2015;8(11):21098-21105 www.ijcem.com /ISSN:1940-5901/IJCEM0013012
Original Article Expression of Beclin1 in the colonic mucosa tissues of patients with ulcerative colitis Xiaoqian Hao1,3*, Bin Yang2*, Xingshan Liu3, Huixiang Yang3, Xishuang Liu1 Department of Gastroenterology, Affiliated Hospital of Qingdao University, Qingdao 266003, China; 2Department of Neurosurgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, China; 3Department of Gastroenterology, Weifang Traditional Chinese Hospital, Weifang 261041, China. *Equal contributors and co-first authors. 1
Received July 17, 2015; Accepted September 2, 2015; Epub November 15, 2015; Published November 30, 2015 Abstract: To investigate the expression of Beclin1 in the colonic mucosa tissue of patients with ulcerative colitis (UC), which acts as a regulator of autophagy and might play a part in the disease progression potentially. A total of 112 patients were selected from September 2013 to November 2014, and their colonic mucosal tissues were collected as the subject of study. Among them, 75 cases were diagnosed with ulcerative colitis (UC), 37 cases were diagnosed with irritable bowel syndrome (IRS) during the same time, which was set as the control group. The mucosal tissues were processed with ELISA and IHCA to measure the expression level of Beclin1, and correlation analysis was performed to demonstrate its role in the disease progression. The expression level pf Beclin1 was significantly higher in the UC patients compared with the control group (P
Original Article Expression of Beclin1 in the colonic mucosa tissues of patients with ulcerative colitis Xiaoqian Hao1,3*, Bin Yang2*, Xingshan Liu3, Huixiang Yang3, Xishuang Liu1 Department of Gastroenterology, Affiliated Hospital of Qingdao University, Qingdao 266003, China; 2Department of Neurosurgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, China; 3Department of Gastroenterology, Weifang Traditional Chinese Hospital, Weifang 261041, China. *Equal contributors and co-first authors. 1
Received July 17, 2015; Accepted September 2, 2015; Epub November 15, 2015; Published November 30, 2015 Abstract: To investigate the expression of Beclin1 in the colonic mucosa tissue of patients with ulcerative colitis (UC), which acts as a regulator of autophagy and might play a part in the disease progression potentially. A total of 112 patients were selected from September 2013 to November 2014, and their colonic mucosal tissues were collected as the subject of study. Among them, 75 cases were diagnosed with ulcerative colitis (UC), 37 cases were diagnosed with irritable bowel syndrome (IRS) during the same time, which was set as the control group. The mucosal tissues were processed with ELISA and IHCA to measure the expression level of Beclin1, and correlation analysis was performed to demonstrate its role in the disease progression. The expression level pf Beclin1 was significantly higher in the UC patients compared with the control group (P
