ONCOLOGY LETTERS 11: 69-74, 2016
Expression and prognostic value of SFRP1 and β-catenin in patients with glioblastoma LIANG CHANG1*, XUHUI LEI2*, YU QIN3, GUANGCHUN ZENG3, XUEXIN ZHANG1, HUA JIN1, CHAO WANG1, XIN WANG1 and JUN SU1 1
Department of Neurosurgery, The Tumor Hospital; 2Department of Neurosurgery, The Second Affiliated Hospital; 3 Department of Pathology, The Tumor Hospital, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China Received October 24, 2014; Accepted September 4, 2015 DOI: 10.3892/ol.2015.3873 Abstract. The roles of secreted frizzled‑related protein‑1 (SFRP1) and β ‑catenin in human cancer have been widely studied, and it has recently been demonstrated that these proteins are associated with numerous human carcinomas. However, their clinical significance in glioblastoma multiforme (GBM) has not been examined. The current study aimed to analyze the correlation between the expression of SFRP1 and β‑catenin, and clinicopathological characteristics in GBM patients. The expression of SFRP1 and β‑catenin was assessed by immunohistochemistry in 113 samples of GBM and 40 normal brain tissues. Compared with normal brain tissues, GBM tissues exhibited significantly lower expression of SFRP1, and higher expression of β‑catenin (both P
Expression and prognostic value of SFRP1 and β-catenin in patients with glioblastoma LIANG CHANG1*, XUHUI LEI2*, YU QIN3, GUANGCHUN ZENG3, XUEXIN ZHANG1, HUA JIN1, CHAO WANG1, XIN WANG1 and JUN SU1 1
Department of Neurosurgery, The Tumor Hospital; 2Department of Neurosurgery, The Second Affiliated Hospital; 3 Department of Pathology, The Tumor Hospital, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China Received October 24, 2014; Accepted September 4, 2015 DOI: 10.3892/ol.2015.3873 Abstract. The roles of secreted frizzled‑related protein‑1 (SFRP1) and β ‑catenin in human cancer have been widely studied, and it has recently been demonstrated that these proteins are associated with numerous human carcinomas. However, their clinical significance in glioblastoma multiforme (GBM) has not been examined. The current study aimed to analyze the correlation between the expression of SFRP1 and β‑catenin, and clinicopathological characteristics in GBM patients. The expression of SFRP1 and β‑catenin was assessed by immunohistochemistry in 113 samples of GBM and 40 normal brain tissues. Compared with normal brain tissues, GBM tissues exhibited significantly lower expression of SFRP1, and higher expression of β‑catenin (both P
