August 2,
THE INFLUENCE OP SNAKE POISON, &c?BY J. FATHER.
I860".]
ORIGINAL
COMMUNICATIONS.,
/
153
time in captivity, and lias bitten before) in the thigh. The fang punctures wero at once washed with the Condy's solution, which
well rubbed ip. 3-40.?Bitten leg partially paralysed.
was
EXPERIMENTS ON THE INFLUENCE OF SNAKE POISON AND ON THE INJECTION OF CERTAIN FLUIDS INTO THE VENOUS CIRCULATION AS AND ON THE APPLICATION OF THE LIGATURE AND ACTUAL CAUTERY.
ANTIDOTES,
Br J. Fayeee, M.D., C.S.I. Present: De. Fatbee ; De. Ewabt, Professor of and Me. Sceva.?June 12th, 1869.
Physiology ;
Expebiment No. 1. A fowl -was bitten in the
thigh by
a
spectacled
cobra that had
been kept in confinement for some weeks, had bitten before, and was, therefore, not fresh. The fowl was bitten at 3 p. m.
staggering ; fifteen drops of 6trong Condy's by Messrs. Scott, Thompson and Company, was injected with the hypodermic syringe into the fowl's thigh. 3-2*50.?Fell down paralysed. 3-4.?Lies almost dead; just breathing. At 3-1-50.?Fowl furnished
solution,
3-5.?Convulsed.
3-7.?Dead. Death occurred in seven minutes ; but the bird wa3 evidently unconscious after the first 2? minutes. I could not recognise any
good
effect from the
injection.
Expebiment No. 2. The left crural vein of a dog was exposed, ready to receive the injection. The dog was then bitten by a cobra in the right
thigh at 3-20 p. m. The cobra was not fresh, it had been in captivity for some time, and had bitten before ; but it was tolerably vigorous. 3-23.?Dog is excited and restless. 3-24.?Same condition ; whining. 3-27.?Much excited; trying to break loose; is salivated j breathing hurried. 3.37.?Is beginning to show signs of the influence of the poison 5 is slightly convulsed j falls over. 3-37-30.?Injected 60 drops of liquor ammonia; sp. gr. *959, into the crural vein ; followed immediately by convulsive twitehing8 of mouth and limbs. 3-42.?Lying down, very low, almost motionless; irregular action of the heart j injected 40 drops more of the liquor ammoniac. 3-43.?No
change ; heart's action very feeble. perfectly still, as though dead; no respiration very irregularly ; 35 pulsations in 30 seconds.
3-44.?Lies heart beats
3-50.?Lying down; when raised can stand, but quickly lies again ; is quite intelligent. 3-51.?Droops his head. 3-52.?GO more drops of the fluid injected into tho vein. 3-54.?5" injected into tho bowel j is able to sit or stand, but is very weak. Tho injection of tho Condy was not followed by convulsions as in tho case of the liquor ammonia;. 3-58.?Lies down ; head falls over ; breathing hurried ; rises and staggers a little, and sits down again. 4. p. m.? Lies sluggish and dejected ; can walk when raised, but staggers and soon sit3 down again. 4-5.?Can still stand and walk with staggering gait. 4-7.?Lying down, but gets up and walks a few steps; head drooping, and look dejected; twitching of musclea generally. 4-8.?When put on hie legs can still stand; breathing hurried ; coat staring. 4-12.? 40 more drops injected into jugular vein. Slight twitching of muscles generally ; lies down on his side, cannot rise; limbs paralysed ; pupils dilated; elight convulsions of extremities, and muscular system generally; breathing catching and rather slow. 4-22.?Motionless; heart still beats 50 in the minute j no, respiration. down
;
4-24.?Ilcart still felt. 4-25.?Dead. Bitten at 3-48?Dead at 4-25 ; in 37 minutes. Death occurred in about the usual time, and with the usual symptoms in which it occurs, when a dog is bitten by a cobra. I do not believe tho effects of the poison were in any way influenced by tho permanganate. Post-mortem at 4-40 p. m. Lungs much collapsed and very pallid. Both sides of heart full of fluid blood ; great vessels distended. The blood coagulated
firmly when lot out of tho heart and vessels. Abdominal viscera not so pallid ns in the other dog. Brain vessels on surfaco, full of blood ; cercbral substanco pale, scarcely any puncta. Expedient No. 4. A fowl bitten
by
a
no
congestion.
black clots. Left ventricle contained a little dark fluid blood. The viscera generally were pallid; but the liver was somewhat congested. Brain,?cerebral substance free from congestion ; vessels on surface slightly distended with blood. The blood
generally coagulated firmly.
^
The external jugular vein of
a
dog
was
exposed at
at 4-45
a
large
cobra
(not fresh, for
following experiments were tried with tho objcct or again testing the effect of tho cobra poison on itself,
it has been some
of on
another cobra. avoid tho A cobra was bitten sufficiently near tho tail to chance of injuring any of the viscera, by another full-grown, fresh, and vigorous cobra. The snake bit deeply, plunging its twice or thrice into the flesh of the other cobra, which an
fangs
then put aside in
13th,
3-34 p. m.;
drops of the liquor potas: permanganat: (Condy's) was injected into the vein at 3-35. No effect produced at the time j the dog did not appear to take any notice of the injection. 3-40.?Dog apparently not affected. 3-45.?Seems rather depressed, but this is not marked j it may
be fear. 3-48.?Bitten by
thigh,
Tho
was
Expeeiment No. 3. 40
in the
Exfeeijient No. 5.
body at 4-20 p. m. Lungs, Heart, right side much distended with
Post-mortem, examination of ;
(not fresh)
at 4-45 p. m.; in 30 seconds it was in violent convulsions. 4-46.?20 more drops injected. Dead before it could be placed on the ground.
3-45.?Dead.
pallid
cobra
p. m.; 20 drops of liquor ammonia having previously, at 4-43, been hypodermically injected into the thigh, no apparent effect produced by the ammonia thus injected. Bitten by the cobra
?
14th, ?
a
separate
cage, and watched. no
change.
6 a. m.
...
...
7 p.
m.
...
...
do.
6
a.
m.
...
...
do.
G p.
m.
...
...
do.
...
...
do.
15th, 6 a. m. The snake evidently has
not suffered.
ExrEBiMENT No. 6.
vigorous and fresh full-grown cobra, with one occellus in hood the (KeautiahJ of tho natives, was made to bite'himself A
154
THE INDIAN MEDICAL GAZETTE.
three
or
four times
near
the tail at 4-48 p.m.
He bit himself
quite as freely as he would have bitten another snake, brought blood, and smeared the surface 'with poison 3 put into a cage and watched. Was not the least affected on the 15 th, three
days
after
the bite.
species.
Present; Dbs. Fayber, Ewabt, Walxee, and Mr. ScEVi.?June 19th, 1869. Expebiment No. 7. A
by
a
was,
full-grown cat was bitten at 2-43 p. m. in the right thigh, large daboia. The snake had been long in captivity, and therefore, most probably not vigorous, though active
daboia, which after such long confinement, without -water, yet retained the power of causing death.* These experiments were made in reference to certain sug-
ture of the or
gestions that have appeared in the journals, but not with any expectation on my part that any other result than that which occurred could take place. The poison of the deadly snakes, of whatever family, kills by paralysing the nerve centres, and it acid to prove antidotal appears as reasonable to expect Prussic to aconite, a3 the cobra poison to be so to that of any other form of venomous snake. A fowl was bitten
Experiment No. 10. same daboia in the
by the
down ; looks sluggish. 4-15.?Rises and runs about, but is lame. 4-27.?"Walks, but is very lame on the bitten
and vicious.
4-10?Sitting
2-49.?Twitching of the muscles ; restless. 3-12. The cat appears to be unaffected. 3-15.?The daboia again made to close his jaws on the cat's though evidently unwilling to bite. thigh, ' 3-44.?The cat seems sluggish, and is evidently now feeling
4-45.?Still walks about, but is
the poison. 3-45.?Bitten
by
cobra on the thigh. in its gait; breathes hard ; looks
a
unsteady
distressed. 4-7.?Cat is restless ; tries to rise, and staggers. 4-10.?Tries to stand, but falls over. 4-18.?Respiration very hurried ; cannot stand; twitching of the muscles. 4-24.?Lies quite paralysed ; pupils dilated j breathing hard. 4-27.?Convulsed. 4-30.?Dead. The cat was bitten by the daboia at 2-43 p. m., and again at 3-15. The snake was old and feeble ; it has been in captivity for more than six months, during which time it has touched neither food nor water, and yet it was active and vicious, hissing fiercely at any one who came near it; that it was capable of secreting poison was evident in later experiments. The cobra bit at 2-45 ; and death occurred at 4-30; that is, in one hour and forty-seven minutes. The cobra was also not fresh, and its poison was weak, perhaps scanty. There was nothing whatever in this experiment to make us think that the cobra's poison proved antidotal to that of the daboia j on the contrary, it rather expedited death. Experiment No. 8. A fowl was bitten in the thigh by the same daboia at 3-40. The snako would not bito until his jaws were closed on the
bird's thigh. 3-44.?The fowl, whilst walking about with rather
gait, suddenly
sprang off the
ground,
sluggish
a
and fell over in convul-
It was immediately bitten 111 the thigh by a cobra. It continued unconscious and convulsed, and was dead at 3-46 ; that is, in six minutes after it was bitten by the viper. Had this viper been fresh, the bird would probably not have lived sions.
one
minute.
Experiment No. 9. Another fowl bitten by the same daboia at 3-56 p.
limps ; has a depressed look, 3-59?Bitten by a cobra-in the thigh; 4-2.?Slight convulsions.
3-58.?It
4-3.?Comb livid
4-5.?Dead,
;
at 4-7 p.m,
leg.
and lame, and looks
was
this,, began to recover, and on the 21st, two quite well. The snake was evidently all but quite
exhausted when he bit this bird. Experiment No. 11. The external jugular vein of a dog was exposed at 3-6 p.m., and four drops of cobra-poison were injected ; at least one drop was lost, the other three entered the vein. 3-10.?Dog looks dejected, and ears drooping; lie lies down.
3-33.?Beyond being sluggish, no symptoms of poisoning. 3-4G.?"Very sluggish; lies down. 3-47.?Liquor ammonia;, sp. gr. -959, 60 drops injected into jugular vein ; dog lies quiet. Heart beating rapidly ; respiration very feeble. 3-54.?Heart's action very rapid; breathing rapid j muscular twitchings. 3-57.?Injected 60 more drops into the veinj muscular twitchings continue. 3-59.?Dead. Poison injected at 3-4 ; death at 3-59. Death in 55 minutes. The quantity of poison was very small from a weakened snake ; no effect was produced by the ammonia. Experiment No. 12. The
jugular vein was exposed in a dog ; it was then bitten in the thigh by a fresh cobra at 3-27. 3-28.?Staggering ; excited, springing ; howling violently ; and trying to break the cord by which it is tied. 3-29.?Quiet; sitting down. 3 30.?Head drooping. 3-33.?Lying on its side, slightly convulsed ; sixty drops of a solution of quinine, of the strength of one grain in eight drops was injected into the jugular vein. 3 34. The dog lies 011 its side, still slightly convulsed.
3-35.?Dead. Bitten at 3 27 ; dead at 3-35, in eleven minutes. The quinine
evidently
did
no
good. Experiment No. 13.
m.
and its comb
droops.
lies down.
convulsed and unconscious.
in nine minutes.
These three experiments, I think, dispose of the question of poison of one family of venomous snakes being antidotal to tb mother, the
sluggish
thigh
very dejected. The fowl, after
days later,
3-46.?The cat is
ISGft
In tbese cases, the viper was old and exhausted, and yet liis a poison was deadly. The poison of the cobra, which was also partially exhausted snake selected 011 purpose, had no counteracting effect. The only thing proved is the terribly deadly na-
food
These two experiments, which were very carefully performed, tend to prove that the cobra cannot poison itself or its own
[August 2,
Equal parts of cobra-poison and liquor ammonia, sp. gr. ?959, were mixed together, and fifteen drops of the mixed fluid were injected with the hypodermic syringe into a pigeon's thigh at 4-30 p. m. Pigeon crouched immediately ; at 4-31; was unable to stand ; the beak resting on the ground. 4-32.?Convulsed
:
peculiar
convulsive movements of the tail
continuing. 4-32.?Dead. *
The daboia was not intentionally would t^ke neither,
deprived
of
food
or
water ; it
August 2,
THE INFLUENCE OF SNAKE
1869.]
4-30; death at 4-32, in two minutes. This experiment is very unfavorable to the theory of the antidotal action at
Injected
of
liquor
ammonia?.
Experiment No. 14. The external jugular vein of
been
a large and powerful dog having (10) drops of fresh cobra-poison were inject4-24 witli the hypodermic syringe. The dog staggered, was convulsed, and fell over
exposed,
ed into it at 4-24-30.
ten
at the mouth.
foaming
4-25.?Violently convulsed,
but with no
out-cry
or
sign
of
suiTering. Sixty drops .
of liquor ammonia, sp. gr. *959, injected. Dead. Death occurred in about 70 seconds ; shewing the frightful virulence of the poison when it finds entry by a large blood vessel. IIow can such
haustion of the
a
death be explained otherwise than by
nerve
centres ?
surely totally inapplicable Present
Dr.
;
Father,
Any theory
of
here.
Da.
ex-
blood-change
is
Ewart, Professor of Physiology 26th, 1869.
j
and Dr. Sceva.?June
bitten in the fore-arm
dog by (kalla keautia) at 3-2 p.m. A ligature had been thrown round the limb above the bitten part, which was immediately tightened ; a pointed steel, heated to a red heat, was then, ?t 3-3 p.m., inserted into the punctures, and the wounds were thoroughly cauterized. 3-7.?The dog is restless, and is apparently under the influence of the poison. 3-12.?Staggers as he walks. 3-14.?Forty drops of liquor ammoni? sp. gr. '959, diluted with three parts of water, were injectcd into the jugular vein. 3-17.?The dog runs about excited ; he was partially convulsed during the injection of the ammonia; now sits up, and then falls over backwards ; breathing quickly. was
3-20.?Lies down
3-38.?Lying
;
is salivated.
paws the air ; muscular on his side ; convulsed.
3-27-?Sits down
cobra
a
;
3-44.?Lies paralysed 3-45.?Dead.
;
heart still
beats,
twitchings.
but no
respiration.
Notwithstanding the ligature, which was tightened immediately, the actual cautcry, which also immediately followed tiie cobra's fangs, and the injection of ammonia into the venous circulation, the snake-poison proved fatal to a full-grown dog in forty-three minutes. Experiment No. 10. A
dog
was
bitten
by a fresh a ligature
cobra
(kalla keautia)
in the fore-
was immediately tightened round at 3-38 p.m.; the limb above the wound. The actual cautery was at once until the fang wounds and the adjacent parts were arm
applied, completely disorganized. 3-42.?The dog is sitting, but
reels as
though
he would
fall over.
3-49.?Rises and walks with a staggering gait. 3-54.?Sits down; attempts to get up, and falls over backwards. 3-57.?Is convulscd; falls over, cannot stand; hurried
breathing. 4-4.?Cannot move ; lies paralysed; heart still respiration almost ceased ; pupils widely dilated. 4-G.?Lies on his side ; convulsed. 4-12.?No respiration ; but heart atill beats feebly.
4-13.?Dead.
beating
j
&c.?BY J. FATHER.
155
also, notwithstanding the ligature which was tightly as two persons could pull it round the leg, and the deep and thorough actual cauterization, immediately after the bite, the snake-poison found entry into the Bjstem, and proved fatal in thirty-five minutes. The dog was much smaller than that of the first experiment. Nothing, it seems to me, can more strongly demonstrate the extremely subtle and virulent nature of the cobra-poison than those experiments ; nothing, I think, is more significant of tho improbability of anything proving to bo an antidote. If the poison find entry into the blood vessels, and be carried to the nerve centres, I am inclined to believe that nothing can prove of any avail, excepting in those cases where the bite is imperfect, the quantity or the quality of tho poison diminished or deteriorated, or the snake itself is young, weak, exhausted, or is one of less poisonous family ; such, I believe, arc the only cases in which recovery occurs through the inherent vigour of the animal or person bitten, perhaps aided by stimulants and excitement. The favourable result is attributed, and naturally enough, by In tliis case
applied
as
those who do not understand the modus Icedendi of the venom, to the treatment and the so-called antidote. That we can aid in such recoveries, and that we may do much to help the sufferer through the troubles arising from general disorder and
Experiment No. 15. A Pariah
POISON,
secondary
blood poisoning, I have no doubt; and I would
offer every encouragement to all to persevere in their attempts. But I must state my conviction that nothing that can properly be called an antidote to cobra or viper poison exists; and the more this is known the better, for mistaken notions on such an important matter can only do harm, and may be the cause
of
losing,
rather than of
Baving,
life.
belief is that, if an animal, and probably a man, be fairly bitten by a fresh and vigorous cobra or daboia, it, or ho, will inevitably succumb; unless some immediate and direct method of arresting tho entry of tho poison into the circulation bo
My
practised. That such may bo done I will not dony 5 but the two experiments just recorded, performed with the greatest care and speed, by two surgeons accustomed to such operations, shew that, at the least, it is very difficult. The moment of time that intervenes between the injection of tho snake-poison by tho powerful maxillary muscles through the tube-like fang, into the minute blood-vessels of tho part, and tho application of the ligature and actual cautery is sufficient to allow of tho entry of tho poison into the circulation, and this reaching tho nerve centres even in a small quantity, may prove fatal. Tho ligature is evidently very unreliable when applied to largo parts of the body, such as the limbs; for it is almost physically impossible to compress the part so tightly as to stop the circulation ; and unless this be done to the depth of tho penetration of the snake's fangs, it is obvious that it can only be of very partial effect in preventing tho entry of the poison. On a finger or a too the ligature might bo of more servico, as the smaller but unless tho ligature part might be thoroughly strangulated j it is obvious that it would bo uselesa were applied immediately, have already entered, and bo on even there, for the poison would its course towards the nerve-centres. How quickly this occurs is proved by those experiments in which the poison was injected directly into the jugular vein. What took place there, with the hypodermic needle inserted into tho jugular vein, lias its exact counterpart in the case of the cobra's fang, inserted, as it must into tho minute veins. be, when it penetrates a vascular part, The same may be said of the actual cautery. Unless the hot iron enter the puncture directly after the fang has been withdrawn, the poison is already far 011 its way towards tho centre, and the burning, though it destroys the tissues and such of tho as may not yet have entered tho circulation, can have 110
poison
influence
on
that which is already beyoad its reach.
But
as
tho
;
156
1
ligature, if tightly and quickly applied, and the actual cautery, if promptly and thoroughly inserted, must limit to a certain extent the entrance of the poison : both should be had recourse to as speedily and efficaciously as possible, in the liope that the amount of poison left to find, or that may have already found, its way into the system, may be less than is sufficient death.
to cause
"
To conceive of an antidote, in the true sense of the term, to snake-poison, one must imagine a substance so subtle as to follow, overtake, and neutralize the venom in the blood, or that shall have the power of counteracting and neutralising the deadly influence it has exerted on the vital forces. Such a substance has still to be found, and our present experience of the action of drugs does not lead to hopeful anticipation that But I
repeat
that where the
poisonous
effects are
produced
minor degree, or when the secondary consequences are to be dealt with, we may do much to aid the natural forces in in
4-10.?Convulsed. 4-17.?Still convulsed; comb livid. 4-20.?Dead in 17 minutes. A fifth fowl bitten in the thigh by the same cobra at 4-13 p. m. 4-20.?Crouches ; comb drooping. 4-24.?Head drooping; resting on beak. 4-29.?Quite
paralysed;
p.
This is not,
recovery.
however,
insertion of the fluid was 4-27-30. The effect was instantaneous ; the dog struggled, howled, and was convulsed on the table : he was immediately released and placed on the ground, but was
already
almost unconscious and convulsed. He made an effort to legs, and fell prone on his belly. Within one minute
rise on his
respiration had ceased, though the heart's action continued faintly. This ceased, and at 4-30 a. in. he was quite dead. The action of the poison with the ammonia wis frightfully rapid in this case. Death occurred in two minutes and a half, complete unconsciousness within a minute ; and only by the faint beating of the heart, which only continued for two and a half minutes, was any sign of life manifested. This surely is fatal to the theory of ammonia injected into the circulation being of any benefit in snake-poisoning. In this case the poison and the socalled antidote were injected synchronously; the result was
almost instant death. The experiment was performed by Dr. Ewart and myself ?with the greatest care, and certainly no air entered the vein.
Experiment No. 18. The cobra that bit the
dog
in the first
experiment bit a fowl immediately began t0
in the thigh, at 3-46 p. m. The bird limp, and then crouched, and then fell over. 3-47.?Head fallen over, beak resting on the
ground.
3-49.?Convulsed ; dead. Death occurred in three minutes. A second fowl
was
bitten
by
the same
snake,
at 3-50 p. m., in
the
thigh. 3-51.?Drooping
bis wings. 3-55.?Sits down, beak resting on the 3-57.?Is convulsed.
ground.
4 p. m.?Dead in ten minutes. A third fowl bitten by the same snake in the
thigh
at 3-51
p. m., shortly after drooped. 3-58.?Convulsed. 4-2.?Dead. Dead in 11 minutes. A fourth and larger fowl bitten in the cobra at 4-3 p.
thigh by
the
same
m.
4-8.?Crouching ; wings spread out; gets up ; tries droops, beak resting on the ground.
and falls j head
leg,
to run,
and then falls over
on
again.
5-22.?Dead in 45 minutes. This was the nintli animal bitten
by
the cobra in
cession,
rapid
suc-
and still it is apparently not quite exhausted. A sixth fowl bitten in the thigh by the same cobra at 4-
32 p.
m.
4-35.?Crouching. 4-47.?Staggers. 5-45.?Lying down insensible.
6-5.?Dead in 9.9 minutes. A seventh fowl bitten by the same cobra in the
34 p.
A large and powerful dog had the right external jugular vein exposed. Twenty drops of a mixture of fresh cobra poison, taken from the snake the same day, one part, and liq. ammonia), sp. gr. 959, forty drops or two parts, was then injected with the hypodermic syringe into the vein. The time of the
cobra at 4-37>
4-47.?The pigeon is drooping, and when he stands, it is
what is meant
Experiment No. 17.
same
m.
one
a
bringing about by an antidote.
convulsed.
4-35.?Dead in 22 minutes. A pigeon -was bitten in the thigh by the
shall find it.
we
[August 2, 18G&.
THE INDIAN MEDICAL GAZETTE.
m.
thigh
at 4
'
.
4-37.?Crouches. 4-47.?Seems sluggish, and limps. 27th June, 5-30 a.m.?Lying down, and eyes half closed; unable to walk. 28th June, 6 a.m.?Is
recovering; walks sluggishly and limps, evidently regaining strength. The object of this experiment was to test the extent of power possessed by the cobra. It destroyed one dog six, fowls, and a pigeon in rapid succession, but the intervals between the bite and the death of each was prolonged, showing the gradual diminution of power at each bite. The seventh fowl poisoned was only slightly so, and recovered. The cobra was neither a very large nor a very vigorous one and yet how deadly I Eight creatures destroyed by a rapid succession of bites. The experiment proves that the snake becomes weaker by biting until quite exhausted. but is
.Expebiment No. 19. A daboia
was
bitten by a fresh cobra (kalla keautia) near the far from the viscera. The scales were previously
tail, sufficiently scraped off. The snake bit fiercely and repeatedly at 4-54 p.
m.
6 p. m.?No change. On the 28th June, at 6 a. m., there was no change. The object of this experiment was to repeat the test of the
influence of the cobra-poison show that it is innocuous.
on
the
viper.
The result tends to
THE INFLUENCE OP SNAKE POISON, &c?BY J. FATHER.
I860".]
ORIGINAL
COMMUNICATIONS.,
/
153
time in captivity, and lias bitten before) in the thigh. The fang punctures wero at once washed with the Condy's solution, which
well rubbed ip. 3-40.?Bitten leg partially paralysed.
was
EXPERIMENTS ON THE INFLUENCE OF SNAKE POISON AND ON THE INJECTION OF CERTAIN FLUIDS INTO THE VENOUS CIRCULATION AS AND ON THE APPLICATION OF THE LIGATURE AND ACTUAL CAUTERY.
ANTIDOTES,
Br J. Fayeee, M.D., C.S.I. Present: De. Fatbee ; De. Ewabt, Professor of and Me. Sceva.?June 12th, 1869.
Physiology ;
Expebiment No. 1. A fowl -was bitten in the
thigh by
a
spectacled
cobra that had
been kept in confinement for some weeks, had bitten before, and was, therefore, not fresh. The fowl was bitten at 3 p. m.
staggering ; fifteen drops of 6trong Condy's by Messrs. Scott, Thompson and Company, was injected with the hypodermic syringe into the fowl's thigh. 3-2*50.?Fell down paralysed. 3-4.?Lies almost dead; just breathing. At 3-1-50.?Fowl furnished
solution,
3-5.?Convulsed.
3-7.?Dead. Death occurred in seven minutes ; but the bird wa3 evidently unconscious after the first 2? minutes. I could not recognise any
good
effect from the
injection.
Expebiment No. 2. The left crural vein of a dog was exposed, ready to receive the injection. The dog was then bitten by a cobra in the right
thigh at 3-20 p. m. The cobra was not fresh, it had been in captivity for some time, and had bitten before ; but it was tolerably vigorous. 3-23.?Dog is excited and restless. 3-24.?Same condition ; whining. 3-27.?Much excited; trying to break loose; is salivated j breathing hurried. 3.37.?Is beginning to show signs of the influence of the poison 5 is slightly convulsed j falls over. 3-37-30.?Injected 60 drops of liquor ammonia; sp. gr. *959, into the crural vein ; followed immediately by convulsive twitehing8 of mouth and limbs. 3-42.?Lying down, very low, almost motionless; irregular action of the heart j injected 40 drops more of the liquor ammoniac. 3-43.?No
change ; heart's action very feeble. perfectly still, as though dead; no respiration very irregularly ; 35 pulsations in 30 seconds.
3-44.?Lies heart beats
3-50.?Lying down; when raised can stand, but quickly lies again ; is quite intelligent. 3-51.?Droops his head. 3-52.?GO more drops of the fluid injected into tho vein. 3-54.?5" injected into tho bowel j is able to sit or stand, but is very weak. Tho injection of tho Condy was not followed by convulsions as in tho case of the liquor ammonia;. 3-58.?Lies down ; head falls over ; breathing hurried ; rises and staggers a little, and sits down again. 4. p. m.? Lies sluggish and dejected ; can walk when raised, but staggers and soon sit3 down again. 4-5.?Can still stand and walk with staggering gait. 4-7.?Lying down, but gets up and walks a few steps; head drooping, and look dejected; twitching of musclea generally. 4-8.?When put on hie legs can still stand; breathing hurried ; coat staring. 4-12.? 40 more drops injected into jugular vein. Slight twitching of muscles generally ; lies down on his side, cannot rise; limbs paralysed ; pupils dilated; elight convulsions of extremities, and muscular system generally; breathing catching and rather slow. 4-22.?Motionless; heart still beats 50 in the minute j no, respiration. down
;
4-24.?Ilcart still felt. 4-25.?Dead. Bitten at 3-48?Dead at 4-25 ; in 37 minutes. Death occurred in about the usual time, and with the usual symptoms in which it occurs, when a dog is bitten by a cobra. I do not believe tho effects of the poison were in any way influenced by tho permanganate. Post-mortem at 4-40 p. m. Lungs much collapsed and very pallid. Both sides of heart full of fluid blood ; great vessels distended. The blood coagulated
firmly when lot out of tho heart and vessels. Abdominal viscera not so pallid ns in the other dog. Brain vessels on surfaco, full of blood ; cercbral substanco pale, scarcely any puncta. Expedient No. 4. A fowl bitten
by
a
no
congestion.
black clots. Left ventricle contained a little dark fluid blood. The viscera generally were pallid; but the liver was somewhat congested. Brain,?cerebral substance free from congestion ; vessels on surface slightly distended with blood. The blood
generally coagulated firmly.
^
The external jugular vein of
a
dog
was
exposed at
at 4-45
a
large
cobra
(not fresh, for
following experiments were tried with tho objcct or again testing the effect of tho cobra poison on itself,
it has been some
of on
another cobra. avoid tho A cobra was bitten sufficiently near tho tail to chance of injuring any of the viscera, by another full-grown, fresh, and vigorous cobra. The snake bit deeply, plunging its twice or thrice into the flesh of the other cobra, which an
fangs
then put aside in
13th,
3-34 p. m.;
drops of the liquor potas: permanganat: (Condy's) was injected into the vein at 3-35. No effect produced at the time j the dog did not appear to take any notice of the injection. 3-40.?Dog apparently not affected. 3-45.?Seems rather depressed, but this is not marked j it may
be fear. 3-48.?Bitten by
thigh,
Tho
was
Expeeiment No. 3. 40
in the
Exfeeijient No. 5.
body at 4-20 p. m. Lungs, Heart, right side much distended with
Post-mortem, examination of ;
(not fresh)
at 4-45 p. m.; in 30 seconds it was in violent convulsions. 4-46.?20 more drops injected. Dead before it could be placed on the ground.
3-45.?Dead.
pallid
cobra
p. m.; 20 drops of liquor ammonia having previously, at 4-43, been hypodermically injected into the thigh, no apparent effect produced by the ammonia thus injected. Bitten by the cobra
?
14th, ?
a
separate
cage, and watched. no
change.
6 a. m.
...
...
7 p.
m.
...
...
do.
6
a.
m.
...
...
do.
G p.
m.
...
...
do.
...
...
do.
15th, 6 a. m. The snake evidently has
not suffered.
ExrEBiMENT No. 6.
vigorous and fresh full-grown cobra, with one occellus in hood the (KeautiahJ of tho natives, was made to bite'himself A
154
THE INDIAN MEDICAL GAZETTE.
three
or
four times
near
the tail at 4-48 p.m.
He bit himself
quite as freely as he would have bitten another snake, brought blood, and smeared the surface 'with poison 3 put into a cage and watched. Was not the least affected on the 15 th, three
days
after
the bite.
species.
Present; Dbs. Fayber, Ewabt, Walxee, and Mr. ScEVi.?June 19th, 1869. Expebiment No. 7. A
by
a
was,
full-grown cat was bitten at 2-43 p. m. in the right thigh, large daboia. The snake had been long in captivity, and therefore, most probably not vigorous, though active
daboia, which after such long confinement, without -water, yet retained the power of causing death.* These experiments were made in reference to certain sug-
ture of the or
gestions that have appeared in the journals, but not with any expectation on my part that any other result than that which occurred could take place. The poison of the deadly snakes, of whatever family, kills by paralysing the nerve centres, and it acid to prove antidotal appears as reasonable to expect Prussic to aconite, a3 the cobra poison to be so to that of any other form of venomous snake. A fowl was bitten
Experiment No. 10. same daboia in the
by the
down ; looks sluggish. 4-15.?Rises and runs about, but is lame. 4-27.?"Walks, but is very lame on the bitten
and vicious.
4-10?Sitting
2-49.?Twitching of the muscles ; restless. 3-12. The cat appears to be unaffected. 3-15.?The daboia again made to close his jaws on the cat's though evidently unwilling to bite. thigh, ' 3-44.?The cat seems sluggish, and is evidently now feeling
4-45.?Still walks about, but is
the poison. 3-45.?Bitten
by
cobra on the thigh. in its gait; breathes hard ; looks
a
unsteady
distressed. 4-7.?Cat is restless ; tries to rise, and staggers. 4-10.?Tries to stand, but falls over. 4-18.?Respiration very hurried ; cannot stand; twitching of the muscles. 4-24.?Lies quite paralysed ; pupils dilated j breathing hard. 4-27.?Convulsed. 4-30.?Dead. The cat was bitten by the daboia at 2-43 p. m., and again at 3-15. The snake was old and feeble ; it has been in captivity for more than six months, during which time it has touched neither food nor water, and yet it was active and vicious, hissing fiercely at any one who came near it; that it was capable of secreting poison was evident in later experiments. The cobra bit at 2-45 ; and death occurred at 4-30; that is, in one hour and forty-seven minutes. The cobra was also not fresh, and its poison was weak, perhaps scanty. There was nothing whatever in this experiment to make us think that the cobra's poison proved antidotal to that of the daboia j on the contrary, it rather expedited death. Experiment No. 8. A fowl was bitten in the thigh by the same daboia at 3-40. The snako would not bito until his jaws were closed on the
bird's thigh. 3-44.?The fowl, whilst walking about with rather
gait, suddenly
sprang off the
ground,
sluggish
a
and fell over in convul-
It was immediately bitten 111 the thigh by a cobra. It continued unconscious and convulsed, and was dead at 3-46 ; that is, in six minutes after it was bitten by the viper. Had this viper been fresh, the bird would probably not have lived sions.
one
minute.
Experiment No. 9. Another fowl bitten by the same daboia at 3-56 p.
limps ; has a depressed look, 3-59?Bitten by a cobra-in the thigh; 4-2.?Slight convulsions.
3-58.?It
4-3.?Comb livid
4-5.?Dead,
;
at 4-7 p.m,
leg.
and lame, and looks
was
this,, began to recover, and on the 21st, two quite well. The snake was evidently all but quite
exhausted when he bit this bird. Experiment No. 11. The external jugular vein of a dog was exposed at 3-6 p.m., and four drops of cobra-poison were injected ; at least one drop was lost, the other three entered the vein. 3-10.?Dog looks dejected, and ears drooping; lie lies down.
3-33.?Beyond being sluggish, no symptoms of poisoning. 3-4G.?"Very sluggish; lies down. 3-47.?Liquor ammonia;, sp. gr. -959, 60 drops injected into jugular vein ; dog lies quiet. Heart beating rapidly ; respiration very feeble. 3-54.?Heart's action very rapid; breathing rapid j muscular twitchings. 3-57.?Injected 60 more drops into the veinj muscular twitchings continue. 3-59.?Dead. Poison injected at 3-4 ; death at 3-59. Death in 55 minutes. The quantity of poison was very small from a weakened snake ; no effect was produced by the ammonia. Experiment No. 12. The
jugular vein was exposed in a dog ; it was then bitten in the thigh by a fresh cobra at 3-27. 3-28.?Staggering ; excited, springing ; howling violently ; and trying to break the cord by which it is tied. 3-29.?Quiet; sitting down. 3 30.?Head drooping. 3-33.?Lying on its side, slightly convulsed ; sixty drops of a solution of quinine, of the strength of one grain in eight drops was injected into the jugular vein. 3 34. The dog lies 011 its side, still slightly convulsed.
3-35.?Dead. Bitten at 3 27 ; dead at 3-35, in eleven minutes. The quinine
evidently
did
no
good. Experiment No. 13.
m.
and its comb
droops.
lies down.
convulsed and unconscious.
in nine minutes.
These three experiments, I think, dispose of the question of poison of one family of venomous snakes being antidotal to tb mother, the
sluggish
thigh
very dejected. The fowl, after
days later,
3-46.?The cat is
ISGft
In tbese cases, the viper was old and exhausted, and yet liis a poison was deadly. The poison of the cobra, which was also partially exhausted snake selected 011 purpose, had no counteracting effect. The only thing proved is the terribly deadly na-
food
These two experiments, which were very carefully performed, tend to prove that the cobra cannot poison itself or its own
[August 2,
Equal parts of cobra-poison and liquor ammonia, sp. gr. ?959, were mixed together, and fifteen drops of the mixed fluid were injected with the hypodermic syringe into a pigeon's thigh at 4-30 p. m. Pigeon crouched immediately ; at 4-31; was unable to stand ; the beak resting on the ground. 4-32.?Convulsed
:
peculiar
convulsive movements of the tail
continuing. 4-32.?Dead. *
The daboia was not intentionally would t^ke neither,
deprived
of
food
or
water ; it
August 2,
THE INFLUENCE OF SNAKE
1869.]
4-30; death at 4-32, in two minutes. This experiment is very unfavorable to the theory of the antidotal action at
Injected
of
liquor
ammonia?.
Experiment No. 14. The external jugular vein of
been
a large and powerful dog having (10) drops of fresh cobra-poison were inject4-24 witli the hypodermic syringe. The dog staggered, was convulsed, and fell over
exposed,
ed into it at 4-24-30.
ten
at the mouth.
foaming
4-25.?Violently convulsed,
but with no
out-cry
or
sign
of
suiTering. Sixty drops .
of liquor ammonia, sp. gr. *959, injected. Dead. Death occurred in about 70 seconds ; shewing the frightful virulence of the poison when it finds entry by a large blood vessel. IIow can such
haustion of the
a
death be explained otherwise than by
nerve
centres ?
surely totally inapplicable Present
Dr.
;
Father,
Any theory
of
here.
Da.
ex-
blood-change
is
Ewart, Professor of Physiology 26th, 1869.
j
and Dr. Sceva.?June
bitten in the fore-arm
dog by (kalla keautia) at 3-2 p.m. A ligature had been thrown round the limb above the bitten part, which was immediately tightened ; a pointed steel, heated to a red heat, was then, ?t 3-3 p.m., inserted into the punctures, and the wounds were thoroughly cauterized. 3-7.?The dog is restless, and is apparently under the influence of the poison. 3-12.?Staggers as he walks. 3-14.?Forty drops of liquor ammoni? sp. gr. '959, diluted with three parts of water, were injectcd into the jugular vein. 3-17.?The dog runs about excited ; he was partially convulsed during the injection of the ammonia; now sits up, and then falls over backwards ; breathing quickly. was
3-20.?Lies down
3-38.?Lying
;
is salivated.
paws the air ; muscular on his side ; convulsed.
3-27-?Sits down
cobra
a
;
3-44.?Lies paralysed 3-45.?Dead.
;
heart still
beats,
twitchings.
but no
respiration.
Notwithstanding the ligature, which was tightened immediately, the actual cautcry, which also immediately followed tiie cobra's fangs, and the injection of ammonia into the venous circulation, the snake-poison proved fatal to a full-grown dog in forty-three minutes. Experiment No. 10. A
dog
was
bitten
by a fresh a ligature
cobra
(kalla keautia)
in the fore-
was immediately tightened round at 3-38 p.m.; the limb above the wound. The actual cautery was at once until the fang wounds and the adjacent parts were arm
applied, completely disorganized. 3-42.?The dog is sitting, but
reels as
though
he would
fall over.
3-49.?Rises and walks with a staggering gait. 3-54.?Sits down; attempts to get up, and falls over backwards. 3-57.?Is convulscd; falls over, cannot stand; hurried
breathing. 4-4.?Cannot move ; lies paralysed; heart still respiration almost ceased ; pupils widely dilated. 4-G.?Lies on his side ; convulsed. 4-12.?No respiration ; but heart atill beats feebly.
4-13.?Dead.
beating
j
&c.?BY J. FATHER.
155
also, notwithstanding the ligature which was tightly as two persons could pull it round the leg, and the deep and thorough actual cauterization, immediately after the bite, the snake-poison found entry into the Bjstem, and proved fatal in thirty-five minutes. The dog was much smaller than that of the first experiment. Nothing, it seems to me, can more strongly demonstrate the extremely subtle and virulent nature of the cobra-poison than those experiments ; nothing, I think, is more significant of tho improbability of anything proving to bo an antidote. If the poison find entry into the blood vessels, and be carried to the nerve centres, I am inclined to believe that nothing can prove of any avail, excepting in those cases where the bite is imperfect, the quantity or the quality of tho poison diminished or deteriorated, or the snake itself is young, weak, exhausted, or is one of less poisonous family ; such, I believe, arc the only cases in which recovery occurs through the inherent vigour of the animal or person bitten, perhaps aided by stimulants and excitement. The favourable result is attributed, and naturally enough, by In tliis case
applied
as
those who do not understand the modus Icedendi of the venom, to the treatment and the so-called antidote. That we can aid in such recoveries, and that we may do much to help the sufferer through the troubles arising from general disorder and
Experiment No. 15. A Pariah
POISON,
secondary
blood poisoning, I have no doubt; and I would
offer every encouragement to all to persevere in their attempts. But I must state my conviction that nothing that can properly be called an antidote to cobra or viper poison exists; and the more this is known the better, for mistaken notions on such an important matter can only do harm, and may be the cause
of
losing,
rather than of
Baving,
life.
belief is that, if an animal, and probably a man, be fairly bitten by a fresh and vigorous cobra or daboia, it, or ho, will inevitably succumb; unless some immediate and direct method of arresting tho entry of tho poison into the circulation bo
My
practised. That such may bo done I will not dony 5 but the two experiments just recorded, performed with the greatest care and speed, by two surgeons accustomed to such operations, shew that, at the least, it is very difficult. The moment of time that intervenes between the injection of tho snake-poison by tho powerful maxillary muscles through the tube-like fang, into the minute blood-vessels of tho part, and tho application of the ligature and actual cautery is sufficient to allow of tho entry of tho poison into the circulation, and this reaching tho nerve centres even in a small quantity, may prove fatal. Tho ligature is evidently very unreliable when applied to largo parts of the body, such as the limbs; for it is almost physically impossible to compress the part so tightly as to stop the circulation ; and unless this be done to the depth of tho penetration of the snake's fangs, it is obvious that it can only be of very partial effect in preventing tho entry of the poison. On a finger or a too the ligature might bo of more servico, as the smaller but unless tho ligature part might be thoroughly strangulated j it is obvious that it would bo uselesa were applied immediately, have already entered, and bo on even there, for the poison would its course towards the nerve-centres. How quickly this occurs is proved by those experiments in which the poison was injected directly into the jugular vein. What took place there, with the hypodermic needle inserted into tho jugular vein, lias its exact counterpart in the case of the cobra's fang, inserted, as it must into tho minute veins. be, when it penetrates a vascular part, The same may be said of the actual cautery. Unless the hot iron enter the puncture directly after the fang has been withdrawn, the poison is already far 011 its way towards tho centre, and the burning, though it destroys the tissues and such of tho as may not yet have entered tho circulation, can have 110
poison
influence
on
that which is already beyoad its reach.
But
as
tho
;
156
1
ligature, if tightly and quickly applied, and the actual cautery, if promptly and thoroughly inserted, must limit to a certain extent the entrance of the poison : both should be had recourse to as speedily and efficaciously as possible, in the liope that the amount of poison left to find, or that may have already found, its way into the system, may be less than is sufficient death.
to cause
"
To conceive of an antidote, in the true sense of the term, to snake-poison, one must imagine a substance so subtle as to follow, overtake, and neutralize the venom in the blood, or that shall have the power of counteracting and neutralising the deadly influence it has exerted on the vital forces. Such a substance has still to be found, and our present experience of the action of drugs does not lead to hopeful anticipation that But I
repeat
that where the
poisonous
effects are
produced
minor degree, or when the secondary consequences are to be dealt with, we may do much to aid the natural forces in in
4-10.?Convulsed. 4-17.?Still convulsed; comb livid. 4-20.?Dead in 17 minutes. A fifth fowl bitten in the thigh by the same cobra at 4-13 p. m. 4-20.?Crouches ; comb drooping. 4-24.?Head drooping; resting on beak. 4-29.?Quite
paralysed;
p.
This is not,
recovery.
however,
insertion of the fluid was 4-27-30. The effect was instantaneous ; the dog struggled, howled, and was convulsed on the table : he was immediately released and placed on the ground, but was
already
almost unconscious and convulsed. He made an effort to legs, and fell prone on his belly. Within one minute
rise on his
respiration had ceased, though the heart's action continued faintly. This ceased, and at 4-30 a. in. he was quite dead. The action of the poison with the ammonia wis frightfully rapid in this case. Death occurred in two minutes and a half, complete unconsciousness within a minute ; and only by the faint beating of the heart, which only continued for two and a half minutes, was any sign of life manifested. This surely is fatal to the theory of ammonia injected into the circulation being of any benefit in snake-poisoning. In this case the poison and the socalled antidote were injected synchronously; the result was
almost instant death. The experiment was performed by Dr. Ewart and myself ?with the greatest care, and certainly no air entered the vein.
Experiment No. 18. The cobra that bit the
dog
in the first
experiment bit a fowl immediately began t0
in the thigh, at 3-46 p. m. The bird limp, and then crouched, and then fell over. 3-47.?Head fallen over, beak resting on the
ground.
3-49.?Convulsed ; dead. Death occurred in three minutes. A second fowl
was
bitten
by
the same
snake,
at 3-50 p. m., in
the
thigh. 3-51.?Drooping
bis wings. 3-55.?Sits down, beak resting on the 3-57.?Is convulsed.
ground.
4 p. m.?Dead in ten minutes. A third fowl bitten by the same snake in the
thigh
at 3-51
p. m., shortly after drooped. 3-58.?Convulsed. 4-2.?Dead. Dead in 11 minutes. A fourth and larger fowl bitten in the cobra at 4-3 p.
thigh by
the
same
m.
4-8.?Crouching ; wings spread out; gets up ; tries droops, beak resting on the ground.
and falls j head
leg,
to run,
and then falls over
on
again.
5-22.?Dead in 45 minutes. This was the nintli animal bitten
by
the cobra in
cession,
rapid
suc-
and still it is apparently not quite exhausted. A sixth fowl bitten in the thigh by the same cobra at 4-
32 p.
m.
4-35.?Crouching. 4-47.?Staggers. 5-45.?Lying down insensible.
6-5.?Dead in 9.9 minutes. A seventh fowl bitten by the same cobra in the
34 p.
A large and powerful dog had the right external jugular vein exposed. Twenty drops of a mixture of fresh cobra poison, taken from the snake the same day, one part, and liq. ammonia), sp. gr. 959, forty drops or two parts, was then injected with the hypodermic syringe into the vein. The time of the
cobra at 4-37>
4-47.?The pigeon is drooping, and when he stands, it is
what is meant
Experiment No. 17.
same
m.
one
a
bringing about by an antidote.
convulsed.
4-35.?Dead in 22 minutes. A pigeon -was bitten in the thigh by the
shall find it.
we
[August 2, 18G&.
THE INDIAN MEDICAL GAZETTE.
m.
thigh
at 4
'
.
4-37.?Crouches. 4-47.?Seems sluggish, and limps. 27th June, 5-30 a.m.?Lying down, and eyes half closed; unable to walk. 28th June, 6 a.m.?Is
recovering; walks sluggishly and limps, evidently regaining strength. The object of this experiment was to test the extent of power possessed by the cobra. It destroyed one dog six, fowls, and a pigeon in rapid succession, but the intervals between the bite and the death of each was prolonged, showing the gradual diminution of power at each bite. The seventh fowl poisoned was only slightly so, and recovered. The cobra was neither a very large nor a very vigorous one and yet how deadly I Eight creatures destroyed by a rapid succession of bites. The experiment proves that the snake becomes weaker by biting until quite exhausted. but is
.Expebiment No. 19. A daboia
was
bitten by a fresh cobra (kalla keautia) near the far from the viscera. The scales were previously
tail, sufficiently scraped off. The snake bit fiercely and repeatedly at 4-54 p.
m.
6 p. m.?No change. On the 28th June, at 6 a. m., there was no change. The object of this experiment was to repeat the test of the
influence of the cobra-poison show that it is innocuous.
on
the
viper.
The result tends to
