American Journal of Pathology, Vol. 141, No. 1, July 1992
Copyright © American Association of Pathologists
Experimental Pneumococcal Meningitis Causes Central Nervous System Pathology Without Inducing the 72-kd Heat Shock Protein Martin G. TAuber,*t# Stephen L. Kennedy,*# Jay H. Tureen,*t# and Daniel H. Lowensteinl1¶# From the Microbial Pathogenesis Unit,* and the Departments of Medicine,t Pediatrics,* and Neurology,II and the Epilepsy Research Laboratory,$ University of California, San Francisco, and the San Francisco General Hospital, # San Francisco, California
We examined whether experimental pneumococcal meningitis induced the 72-kd heat shock protein (HSP72), a sensitive marker of neuronal stress in other models of central nervous system (CNS) injury. Brain injury was characterized by vasculitis, cerebritis, and abscess formation in the cortex of infected animals. The extent of these changes correlated with the size of the inoculum (P < 0.003) and with pathophysiologic parameters of disease severity, i.e., cerebrospinalfluid (CSF) lactate (r = 0.61, P < 0.0001) and CSF glucose concentrations (r = -0.55, P
Copyright © American Association of Pathologists
Experimental Pneumococcal Meningitis Causes Central Nervous System Pathology Without Inducing the 72-kd Heat Shock Protein Martin G. TAuber,*t# Stephen L. Kennedy,*# Jay H. Tureen,*t# and Daniel H. Lowensteinl1¶# From the Microbial Pathogenesis Unit,* and the Departments of Medicine,t Pediatrics,* and Neurology,II and the Epilepsy Research Laboratory,$ University of California, San Francisco, and the San Francisco General Hospital, # San Francisco, California
We examined whether experimental pneumococcal meningitis induced the 72-kd heat shock protein (HSP72), a sensitive marker of neuronal stress in other models of central nervous system (CNS) injury. Brain injury was characterized by vasculitis, cerebritis, and abscess formation in the cortex of infected animals. The extent of these changes correlated with the size of the inoculum (P < 0.003) and with pathophysiologic parameters of disease severity, i.e., cerebrospinalfluid (CSF) lactate (r = 0.61, P < 0.0001) and CSF glucose concentrations (r = -0.55, P
