Vol.

170,

August

No.

3, 1990

BIOCHEMICAL

AND

BIOPHYSICAL

RESEARCH

COMMUNICATIONS

Pages

16, 1990

EVIDENCE GLYCATION

FOR A RELATIONSHIP

1107-1113

BETWEEN PROTEIN

AND RED BLOOD CELL MEMBRANE

Inb BIRLOUEZ-ARAGON, PamelaSCALBERT-MENANTEAU, MORAWIEC and Majid SHAFIEZADEH

FLUIDITY Marek

Analytical Chemistry laboratory, Institut National Agronomique, 16 rue Claude Bernard, 75005 PARIS, France Received

June

26,

1990

This study examinesthe relationship between protein glycation and membranefluidity in RBC membranes.Incubation of RBC membranesof healthy subjects with 25mM glucoseor galactoseat 37°C induced a 38% (p < 0.02) increasein protein glycation (using furosine determination by HPLC) and higher fluidity @

Evidence for a relationship between protein glycation and red blood cell membrane fluidity.

This study examines the relationship between protein glycation and membrane fluidity in RBC membranes. Incubation of RBC membranes of healthy subjects...
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