Research

Original Investigation

Evaluation of the Association of Maternal Pertussis Vaccination With Obstetric Events and Birth Outcomes Elyse O. Kharbanda, MD, MPH; Gabriela Vazquez-Benitez, PhD; Heather S. Lipkind, MD, MS; Nicola P. Klein, MD, PhD; T. Craig Cheetham, PharmD, MS; Allison Naleway, PhD; Saad B. Omer, PhD; Simon J. Hambidge, MD, PhD; Grace M. Lee, MD, MPH; Michael L. Jackson, PhD; Natalie L. McCarthy, MPH; Frank DeStefano, MD, MPH; James D. Nordin, MD, MPH

IMPORTANCE In 2010, due to a pertussis outbreak and neonatal deaths, the California

Supplemental content at jama.com

Department of Health recommended that the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) be administered during pregnancy. Tdap is now recommended by the Advisory Committee on Immunization Practices for all pregnant women, preferably between 27 and 36 weeks’ gestation. Limited data exist on Tdap safety during pregnancy. OBJECTIVE To evaluate whether maternal Tdap vaccination during pregnancy is associated with increased risks of adverse obstetric events or adverse birth outcomes. DESIGN AND SETTING Retrospective, observational cohort study using administrative health care databases from 2 California Vaccine Safety Datalink sites. PARTICIPANTS AND EXPOSURES Of 123 494 women with singleton pregnancies ending in a live birth between January 1, 2010, and November 15, 2012, 26 229 (21%) received Tdap during pregnancy and 97 265 did not. MAIN OUTCOMES AND MEASURES Risks of small-for-gestational-age (SGA) births (

Evaluation of the association of maternal pertussis vaccination with obstetric events and birth outcomes.

In 2010, due to a pertussis outbreak and neonatal deaths, the California Department of Health recommended that the tetanus toxoid, reduced diphtheria ...
238KB Sizes 1 Downloads 4 Views

Recommend Documents


The association between maternal perception of obstetric and pediatric care providers' attitudes and exclusive breastfeeding outcomes.
Exclusive breastfeeding is recommended for 6 months. Successful breastfeeding requires support from family members, peers, and health care professionals.

Maternal and neonatal vaccination protects newborn baboons from pertussis infection.
The United States is experiencing a pertussis resurgence that resulted in a 60-year high of 48 000 cases in 2012. The majority of hospitalizations and deaths occur in infants too young to be vaccinated. Neonatal and maternal vaccination have been pro

Effectiveness of maternal pertussis vaccination in England: an observational study.
In October, 2012, a pertussis vaccination programme for pregnant women was introduced in response to an outbreak across England. We aimed to assess the vaccine effectiveness and the overall effect of the vaccine programme in preventing pertussis in i

Safety of influenza vaccination during pregnancy: a review of subsequent maternal obstetric events and findings from two recent cohort studies.
Pregnant women and their infants are vulnerable to severe disease and secondary complications from influenza infection. For this reason, annual influenza vaccination is recommended for all pregnant women in the United States. Women frequently cite co

Effect of Fetal Sex on Maternal and Obstetric Outcomes.
Fetal sex plays an important role in modifying the course and complications related to pregnancy and may also have an impact on maternal health and well-being both during and after pregnancy. The goal of this article is to review and summarize the fi

Pregnancy outcomes after antepartum tetanus, diphtheria, and acellular pertussis vaccination.
To evaluate pregnancy outcomes of women who received tetanus, diphtheria, and acellular pertussis (Tdap) vaccination at or after 32 weeks of gestation. Outcomes from consecutive pregnancies during which the mother received Tdap were also analyzed.

Association of BMI and interpregnancy BMI change with birth outcomes in an Australian obstetric population: a retrospective cohort study.
To assess maternal and neonatal outcomes associated with increasing body mass index (BMI) and interpregnancy BMI changes in an Australian obstetric population.

Impact of maternal under nutrition on obstetric outcomes.
Maternal malnutrition, ranging from under nutrition to over dietary intake before and in the pregnant state, is worldwide problem with significant consequences, not only for survival and increased risk for acute and chronic diseases both in mother an

Pertussis vaccination in pregnancy.
Pertussis has had a resurgence with the highest incidence and complication rates in young infants, and deaths occurring mainly at < age 3 months. Infants are infected by older individuals whose immunity has waned. Strategies such as targeted immuniza