728725 research-article2017
DTI0010.1177/1177392817728725Drug Target InsightsOtegbade et al
Ethanol Extract of Blighia sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei–Infected Mice
Drug Target Insights Volume 11: 1–8 © The Author(s) 2017 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1177392817728725 https://doi.org/10.1177/1177392817728725
Olayinka O Otegbade1, Johnson A Ojo1, Dolapo I Adefokun2, Oyindamola O Abiodun3, Bolaji N Thomas4 and Olusola Ojurongbe1 1Department
of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, Osogbo, Nigeria. 2Department of Pharmacology & Therapeutics, Ladoke Akintola University of Technology, Osogbo, Nigeria. 3Department of Pharmacology & Therapeutics, University of Ibadan, Ibadan, Nigeria. 4Department of Biomedical Sciences, College of Health Sciences and Technology, Rochester Institute of Technology, Rochester, NY, USA.
ABSTRACT: This work explores the antiplasmodial potential of ethanol extract of Blighia sapida (Lin. Sapindaceae) in chloroquine (CQ)resistant Plasmodium berghei (ANKA strain)–infected mice. Chloroquine-resistant (ANKA) strain of P berghei was inoculated intraperitoneally into Swiss albino mice. Mice were treated orally for 4 consecutive days, before and after inoculation (prophylactic, suppressive, and curative models) with graded doses of the plant extracts with Artemether-Lumefantrine (Coartem) as control. Prophylactically, the extract showed a remarkable activity in the chemosuppression of P berghei parasites (P
DTI0010.1177/1177392817728725Drug Target InsightsOtegbade et al
Ethanol Extract of Blighia sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei–Infected Mice
Drug Target Insights Volume 11: 1–8 © The Author(s) 2017 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1177392817728725 https://doi.org/10.1177/1177392817728725
Olayinka O Otegbade1, Johnson A Ojo1, Dolapo I Adefokun2, Oyindamola O Abiodun3, Bolaji N Thomas4 and Olusola Ojurongbe1 1Department
of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, Osogbo, Nigeria. 2Department of Pharmacology & Therapeutics, Ladoke Akintola University of Technology, Osogbo, Nigeria. 3Department of Pharmacology & Therapeutics, University of Ibadan, Ibadan, Nigeria. 4Department of Biomedical Sciences, College of Health Sciences and Technology, Rochester Institute of Technology, Rochester, NY, USA.
ABSTRACT: This work explores the antiplasmodial potential of ethanol extract of Blighia sapida (Lin. Sapindaceae) in chloroquine (CQ)resistant Plasmodium berghei (ANKA strain)–infected mice. Chloroquine-resistant (ANKA) strain of P berghei was inoculated intraperitoneally into Swiss albino mice. Mice were treated orally for 4 consecutive days, before and after inoculation (prophylactic, suppressive, and curative models) with graded doses of the plant extracts with Artemether-Lumefantrine (Coartem) as control. Prophylactically, the extract showed a remarkable activity in the chemosuppression of P berghei parasites (P
