http://informahealthcare.com/jmf ISSN: 1476-7058 (print), 1476-4954 (electronic) J Matern Fetal Neonatal Med, 2014; 27(18): 1935 ! 2014 Informa UK Ltd. DOI: 10.3109/14767058.2014.893291
LETTER TO THE EDITOR
Erythropoietin in amniotic fluid Beuy Joob1 and Viroj Wiwanitkit2,3 1
Sanittion 1 Medical Academic Center, Bangkok, Thailand, 2University Editorial Office, Hainan Medical University, Haikou, China, and 3Biological Science, Joseph Ayobabalola University, Nigeria
The recent article on ‘‘erythropoietin in amniotic fluid’’ is very interesting [1]. Mikovic et al. concluded that ‘‘amniotic fluid erythropoietin concentration is elevated in growthrestricted fetuses and could potentially be used for distinction between growth restricted and constitutionally small fetuses’’ [1]. Indeed, relationship of amniotic fluid index and cord blood erythropoietin levels is well confirmed in cases with small for gestational age problems [2]. Determination of erythropoietin in amniotic fluid is a useful investigation. However, other pathological conditions can contribute to aberrations in levels of amniotic erythropoietin (such as parvo virus B19 infection [3] and hypoxia [4]).
Declaration of interest
References 1. Mikovic Z, Mandic V, Parovic V, et al. Erythropoietin in amniotic fluid as a potential marker in distinction between growth restricted and constitutionally small fetuses. J Matern Fetal Neonatal Med 2013. [Epub ahead of print]. doi:10.3109/14767058.2013.851184. 2. Doi S, Osada H, Seki K, Sekiya S. Relationship of amniotic fluid index and cord blood erythropoietin levels in small for and appropriate for gestational age fetuses. Obstet Gynecol 1999;94: 768–72. 3. Yoshida M, Matsuda H, Yoshinaga Y, et al. Analysis about the influence on the fetus infected with parvovirus B19 using amniotic erythropoietin and troponin-T. Arch Gynecol Obstet 2013;288: 521–5. 4. Teramo KA, Widness JA. Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of intrauterine hypoxia. Neonatology 2009;95:105–16.
The authors report no conflicts of interest.
Address for correspondence: Beuy Joob, Sanittion 1 Medical Academic Center, Bangkok, Thailand. E-mail: [email protected]
Copyright of Journal of Maternal-Fetal & Neonatal Medicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
LETTER TO THE EDITOR
Erythropoietin in amniotic fluid Beuy Joob1 and Viroj Wiwanitkit2,3 1
Sanittion 1 Medical Academic Center, Bangkok, Thailand, 2University Editorial Office, Hainan Medical University, Haikou, China, and 3Biological Science, Joseph Ayobabalola University, Nigeria
The recent article on ‘‘erythropoietin in amniotic fluid’’ is very interesting [1]. Mikovic et al. concluded that ‘‘amniotic fluid erythropoietin concentration is elevated in growthrestricted fetuses and could potentially be used for distinction between growth restricted and constitutionally small fetuses’’ [1]. Indeed, relationship of amniotic fluid index and cord blood erythropoietin levels is well confirmed in cases with small for gestational age problems [2]. Determination of erythropoietin in amniotic fluid is a useful investigation. However, other pathological conditions can contribute to aberrations in levels of amniotic erythropoietin (such as parvo virus B19 infection [3] and hypoxia [4]).
Declaration of interest
References 1. Mikovic Z, Mandic V, Parovic V, et al. Erythropoietin in amniotic fluid as a potential marker in distinction between growth restricted and constitutionally small fetuses. J Matern Fetal Neonatal Med 2013. [Epub ahead of print]. doi:10.3109/14767058.2013.851184. 2. Doi S, Osada H, Seki K, Sekiya S. Relationship of amniotic fluid index and cord blood erythropoietin levels in small for and appropriate for gestational age fetuses. Obstet Gynecol 1999;94: 768–72. 3. Yoshida M, Matsuda H, Yoshinaga Y, et al. Analysis about the influence on the fetus infected with parvovirus B19 using amniotic erythropoietin and troponin-T. Arch Gynecol Obstet 2013;288: 521–5. 4. Teramo KA, Widness JA. Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of intrauterine hypoxia. Neonatology 2009;95:105–16.
The authors report no conflicts of interest.
Address for correspondence: Beuy Joob, Sanittion 1 Medical Academic Center, Bangkok, Thailand. E-mail: [email protected]
Copyright of Journal of Maternal-Fetal & Neonatal Medicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
