Accepted Manuscript Epigenomics in toxicology and medicine Saura C. Sahu, Ph.D., Guest Editor PII:
S0278-6915(17)30491-X
DOI:
10.1016/j.fct.2017.08.040
Reference:
FCT 9257
To appear in:
Food and Chemical Toxicology
Received Date: 0278-6915 0278-6915 Revised Date:
0278-6915 0278-6915
Accepted Date: 0278-6915 0278-6915
Please cite this article as: Sahu, S.C., Epigenomics in toxicology and medicine, Food and Chemical Toxicology (2017), doi: 10.1016/j.fct.2017.08.040. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Editorial: Epigenomics in toxicology and medicine: A special issue of the journal “Food and Chemical Toxicology” st
TE D
M AN U
SC
RI PT
Toxicoepigenomics is a new rapidly developing branch of toxicology in the 21 century. Genetics is defined as the heritable changes in gene expression profiles of genomic DNA sequence. In contrast the epigenetics is defined as the heritable changes in gene activity, induced by exposures to environmental factors, in the absence of any alteration to the genomic DNA sequence itself. Recent studies indicate strongly that epigenetics plays important roles in several human diseases such as cancer. Therefore, it has become an important new developing research area in medicine and toxicology. They have the potential of providing molecular biomarkers of toxicity and disease. Because of the international attention on this emerging scientific discipline, the Food and Chemical Toxicology (FCT) decided to publish a Special Issue focusing on this developing area of research to provide up-to-date state-of-the-art information on toxicoepigenomics for its readers. It is my honor, privilege and pleasure to have this opportunity for serving as the guest editor of this Special Issue. This Special Issue provides a productive setting for bringing together investigators of international recognition working actively in this exciting area of research to share their ideas as well as the results of their studies which may ultimately lead to a better understanding of toxicoepigenomics. I express my sincere gratitude to all the participating investigators for sharing my enthusiasm and interest for this Special Issue as well as for their generous contributions, cooperation and support. I sincerely hope that this Special Issue will provide an authoritative and up-todate source of current information in this new area of research and prove useful to the active investigators throughout the world. I encourage our readers to submit the exciting results of their studies to the Food and Chemical Toxicology, which in return promises to provide quick publication following expert peer review.
st
AC C
August 1 , 2017
EP
Saura C. Sahu, Ph.D., Guest Editor Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA. E-mail address: [email protected]
S0278-6915(17)30491-X
DOI:
10.1016/j.fct.2017.08.040
Reference:
FCT 9257
To appear in:
Food and Chemical Toxicology
Received Date: 0278-6915 0278-6915 Revised Date:
0278-6915 0278-6915
Accepted Date: 0278-6915 0278-6915
Please cite this article as: Sahu, S.C., Epigenomics in toxicology and medicine, Food and Chemical Toxicology (2017), doi: 10.1016/j.fct.2017.08.040. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Editorial: Epigenomics in toxicology and medicine: A special issue of the journal “Food and Chemical Toxicology” st
TE D
M AN U
SC
RI PT
Toxicoepigenomics is a new rapidly developing branch of toxicology in the 21 century. Genetics is defined as the heritable changes in gene expression profiles of genomic DNA sequence. In contrast the epigenetics is defined as the heritable changes in gene activity, induced by exposures to environmental factors, in the absence of any alteration to the genomic DNA sequence itself. Recent studies indicate strongly that epigenetics plays important roles in several human diseases such as cancer. Therefore, it has become an important new developing research area in medicine and toxicology. They have the potential of providing molecular biomarkers of toxicity and disease. Because of the international attention on this emerging scientific discipline, the Food and Chemical Toxicology (FCT) decided to publish a Special Issue focusing on this developing area of research to provide up-to-date state-of-the-art information on toxicoepigenomics for its readers. It is my honor, privilege and pleasure to have this opportunity for serving as the guest editor of this Special Issue. This Special Issue provides a productive setting for bringing together investigators of international recognition working actively in this exciting area of research to share their ideas as well as the results of their studies which may ultimately lead to a better understanding of toxicoepigenomics. I express my sincere gratitude to all the participating investigators for sharing my enthusiasm and interest for this Special Issue as well as for their generous contributions, cooperation and support. I sincerely hope that this Special Issue will provide an authoritative and up-todate source of current information in this new area of research and prove useful to the active investigators throughout the world. I encourage our readers to submit the exciting results of their studies to the Food and Chemical Toxicology, which in return promises to provide quick publication following expert peer review.
st
AC C
August 1 , 2017
EP
Saura C. Sahu, Ph.D., Guest Editor Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA. E-mail address: [email protected]
