ZOOLOGICAL RESEARCH
Energy intake, oxidative stress and antioxidant in mice during lactation Guo-Xiao ZHENG, Jiang-Tao LIN, Wei-Hong ZHENG, Jing CAO, Zhi-Jun ZHAO* College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
ABSTRACT
Metabolic rate; Oxidative stress; Uncoupling protein
Reproduction is the highest energy demand period for small mammals, during which both energy intake and expenditure are increased to cope with elevated energy requirements of offspring growth and somatic protection. Oxidative stress life history theory proposed that reactive oxygen species (ROS) were produced in direct proportion to metabolic rate, resulting in oxidative stress and damage to macromolecules. In the present study, several markers of oxidative stress and antioxidants activities were examined in brain, liver, kidneys, skeletal muscle and small intestine in non-lactating (Non-Lac) and lactating (Lac) KM mice. Uncoupling protein (ucps) gene expression was examined in brain, liver and muscle. During peak lactation, gross energy intake was 254% higher in Lac mice than in Non-Lac mice. Levels of H2O2 of Lac mice were 17.7% higher in brain (P
Energy intake, oxidative stress and antioxidant in mice during lactation Guo-Xiao ZHENG, Jiang-Tao LIN, Wei-Hong ZHENG, Jing CAO, Zhi-Jun ZHAO* College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
ABSTRACT
Metabolic rate; Oxidative stress; Uncoupling protein
Reproduction is the highest energy demand period for small mammals, during which both energy intake and expenditure are increased to cope with elevated energy requirements of offspring growth and somatic protection. Oxidative stress life history theory proposed that reactive oxygen species (ROS) were produced in direct proportion to metabolic rate, resulting in oxidative stress and damage to macromolecules. In the present study, several markers of oxidative stress and antioxidants activities were examined in brain, liver, kidneys, skeletal muscle and small intestine in non-lactating (Non-Lac) and lactating (Lac) KM mice. Uncoupling protein (ucps) gene expression was examined in brain, liver and muscle. During peak lactation, gross energy intake was 254% higher in Lac mice than in Non-Lac mice. Levels of H2O2 of Lac mice were 17.7% higher in brain (P
