Elimination of Vitamin D Receptor in Vascular Endothelial Cells Alters Vascular Function Wei Ni, Stephanie W. Watts, Michael Ng, Songcang Chen, Denis J. Glenn and David G. Gardner Hypertension. published online September 8, 2014; Hypertension is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 2014 American Heart Association, Inc. All rights reserved. Print ISSN: 0194-911X. Online ISSN: 1524-4563
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://hyper.ahajournals.org/content/early/2014/09/08/HYPERTENSIONAHA.114.03971
Data Supplement (unedited) at: http://hyper.ahajournals.org/content/suppl/2014/09/08/HYPERTENSIONAHA.114.03971.DC1.html
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Original Article Elimination of Vitamin D Receptor in Vascular Endothelial Cells Alters Vascular Function Wei Ni, Stephanie W. Watts, Michael Ng, Songcang Chen, Denis J. Glenn, David G. Gardner See Editorial Commentary , pp xxx-xxx Abstract—Vitamin D deficiency has been associated with cardiovascular dysfunction. We evaluated the role of the vitamin D receptor (VDR) in vascular endothelial function, a marker of cardiovascular health, at baseline and in the presence of angiotensin II, using an endothelial-specific knockout of the murine VDR gene. In the absence of endothelial VDR, acetylcholine-induced aortic relaxation was significantly impaired (maximal relaxation, endothelial-specific VDR knockout=58% versus control=73%; P
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://hyper.ahajournals.org/content/early/2014/09/08/HYPERTENSIONAHA.114.03971
Data Supplement (unedited) at: http://hyper.ahajournals.org/content/suppl/2014/09/08/HYPERTENSIONAHA.114.03971.DC1.html
Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Hypertension can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Hypertension is online at: http://hyper.ahajournals.org//subscriptions/
Downloaded from http://hyper.ahajournals.org/ at CONS CALIFORNIA DIG LIB on September 15, 2014
Original Article Elimination of Vitamin D Receptor in Vascular Endothelial Cells Alters Vascular Function Wei Ni, Stephanie W. Watts, Michael Ng, Songcang Chen, Denis J. Glenn, David G. Gardner See Editorial Commentary , pp xxx-xxx Abstract—Vitamin D deficiency has been associated with cardiovascular dysfunction. We evaluated the role of the vitamin D receptor (VDR) in vascular endothelial function, a marker of cardiovascular health, at baseline and in the presence of angiotensin II, using an endothelial-specific knockout of the murine VDR gene. In the absence of endothelial VDR, acetylcholine-induced aortic relaxation was significantly impaired (maximal relaxation, endothelial-specific VDR knockout=58% versus control=73%; P
