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Heart Online First, published on May 12, 2015 as 10.1136/heartjnl-2014-307334 Arrhythmias and sudden death
ORIGINAL ARTICLE
Elevated plasma norepinephrine level and sick sinus syndrome in patients with lone atrial fibrillation Kentaro Yoshida,1,2 Takashi Kaneshiro,2 Yoko Ito,1 Akira Kimata,1,2 Naoya Koda,1 Daigo Hiraya,1 Masako Baba,1 Masako Misaki,1 Noriyuki Takeyasu,1,2 Iwao Yamaguchi,3 Kazutaka Aonuma2 1
Division of Cardiovascular Medicine, Ibaraki Prefectural Central Hospital, Kasama, Japan 2 Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan 3 Ibaraki Health Service Association, Mito, Japan Correspondence to Dr Kentaro Yoshida, Cardiovascular Division, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan; [email protected] Received 16 December 2014 Revised 1 April 2015 Accepted 16 April 2015
ABSTRACT Objective Plasma norepinephrine (NE) level can be a guide to mortality in patients with heart failure. This study aimed to evaluate the significance of plasma NE level compared with plasma natriuretic peptides (atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)) levels in patients with atrial fibrillation (AF). Methods Included in this study were 137 consecutive patients referred for catheter ablation of lone AF ( paroxysmal in 90 and persistent in 47 patients). Blood samples for measurements of ANP, BNP and NE were drawn in the supine position before the procedure. Results ANP, BNP and NE levels were greater in patients with persistent AF than in patients with paroxysmal AF (median (25th–75th centile)=28 (18–49) vs 69 (36–106), p
Heart Online First, published on May 12, 2015 as 10.1136/heartjnl-2014-307334 Arrhythmias and sudden death
ORIGINAL ARTICLE
Elevated plasma norepinephrine level and sick sinus syndrome in patients with lone atrial fibrillation Kentaro Yoshida,1,2 Takashi Kaneshiro,2 Yoko Ito,1 Akira Kimata,1,2 Naoya Koda,1 Daigo Hiraya,1 Masako Baba,1 Masako Misaki,1 Noriyuki Takeyasu,1,2 Iwao Yamaguchi,3 Kazutaka Aonuma2 1
Division of Cardiovascular Medicine, Ibaraki Prefectural Central Hospital, Kasama, Japan 2 Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan 3 Ibaraki Health Service Association, Mito, Japan Correspondence to Dr Kentaro Yoshida, Cardiovascular Division, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan; [email protected] Received 16 December 2014 Revised 1 April 2015 Accepted 16 April 2015
ABSTRACT Objective Plasma norepinephrine (NE) level can be a guide to mortality in patients with heart failure. This study aimed to evaluate the significance of plasma NE level compared with plasma natriuretic peptides (atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)) levels in patients with atrial fibrillation (AF). Methods Included in this study were 137 consecutive patients referred for catheter ablation of lone AF ( paroxysmal in 90 and persistent in 47 patients). Blood samples for measurements of ANP, BNP and NE were drawn in the supine position before the procedure. Results ANP, BNP and NE levels were greater in patients with persistent AF than in patients with paroxysmal AF (median (25th–75th centile)=28 (18–49) vs 69 (36–106), p
