Clinical Study Received: May 26, 2013 Accepted after revision: August 30, 2013 Published online: November 5, 2013
Oncology 2013;85:269–277 DOI: 10.1159/000355502
Elevated Plasma Fibrinogen Levels Are Associated with a Poor Prognosis in Patients with Hepatocellular Carcinoma Akiyoshi Kinoshita a Hiroshi Onoda a Nami Imai a Akira Iwaku a Mutumi Oishi a Ken Tanaka a Nao Fushiya a Kazuhiko Koike a Hirokazu Nishino a Masato Matsushima b Hisao Tajiri c
a Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital, b Division of Clinical Epidemiology, and c Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Abstract Objectives: Elevated plasma fibrinogen levels are associated with tumor progression and poor outcomes in cancer patients. We investigated the prognostic value of pretreatment plasma fibrinogen levels in patients with hepatocellular carcinoma (HCC). Methods: One hundred and thirteen patients with newly diagnosed HCC were retrospectively evaluated. We investigated the correlation between pretreatment plasma fibrinogen levels, clinicopathological parameters and overall survival. Both univariate and multivariate analyses were performed to identify the clinicopathological parameters associated with overall survival. Results: The median value of the pretreatment plasma fibrinogen level was 279 mg/dl. Elevated plasma fibrinogen levels were associated with larger tumor size, the presence of vascular invasion and higher Cancer Liver Italian Program scores. Lower plasma fibrinogen levels were associated with higher Child-Pugh grades. The overall survival rates in patients with pretreatment plasma fibrinogen levels ≥315 mg/dl were significantly lower than those with a pretreatment plasma fibrinogen
© 2013 S. Karger AG, Basel 0030–2414/13/0855–0269$38.00/0 E-Mail [email protected] www.karger.com/ocl
level
Oncology 2013;85:269–277 DOI: 10.1159/000355502
Elevated Plasma Fibrinogen Levels Are Associated with a Poor Prognosis in Patients with Hepatocellular Carcinoma Akiyoshi Kinoshita a Hiroshi Onoda a Nami Imai a Akira Iwaku a Mutumi Oishi a Ken Tanaka a Nao Fushiya a Kazuhiko Koike a Hirokazu Nishino a Masato Matsushima b Hisao Tajiri c
a Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital, b Division of Clinical Epidemiology, and c Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Abstract Objectives: Elevated plasma fibrinogen levels are associated with tumor progression and poor outcomes in cancer patients. We investigated the prognostic value of pretreatment plasma fibrinogen levels in patients with hepatocellular carcinoma (HCC). Methods: One hundred and thirteen patients with newly diagnosed HCC were retrospectively evaluated. We investigated the correlation between pretreatment plasma fibrinogen levels, clinicopathological parameters and overall survival. Both univariate and multivariate analyses were performed to identify the clinicopathological parameters associated with overall survival. Results: The median value of the pretreatment plasma fibrinogen level was 279 mg/dl. Elevated plasma fibrinogen levels were associated with larger tumor size, the presence of vascular invasion and higher Cancer Liver Italian Program scores. Lower plasma fibrinogen levels were associated with higher Child-Pugh grades. The overall survival rates in patients with pretreatment plasma fibrinogen levels ≥315 mg/dl were significantly lower than those with a pretreatment plasma fibrinogen
© 2013 S. Karger AG, Basel 0030–2414/13/0855–0269$38.00/0 E-Mail [email protected] www.karger.com/ocl
level
