Efficiency of Disopyramide Stress States
Hypertrophic
Cardiomyopathy
Alain Millaire, MD, Luc Goullard, MD, Eric Decoulx, MD, Pascal de Groote, MD, Yvon Houdas, MD, and Gdrard Ducloux, MD isopyramide is thought to be efficient in treating most casesof hypertrophic cardiomyopathy.’ CliniD cal symptoms, hemodynamic data at rest, and exercise
(EMIT-ABBOTT@--therapeutic range 2 to 5 rig/ml). Student’s paired t test was used for statistical analysis. Nine patients were included in this open study (Table duration are improved by disopyramide.‘-2However, he- I). All patients had a significant obstruction: at rest in 7, modynamic effects of a particular treatment can be dif- and during exercise in 2 (nos. 7 and 8). All patients were ferent at rest and during exercise.Thus, propranolol has in sinus rhythm. Eight patients were in New York Heart little effect on the intraventricular pressure gradient at Association functional class I or II, and 1 was in class III rest, but may diminish the increment that occurs with (patient 9). Patient 3 did not perform exercise, because exercise.3No data are available concerning the hemody- of dyspnea, tachycardia and rest obstruction. Tachycardia rapidly disappeared after hospital discharge, as namic efficiency of disopyramide during exercise. shown by Holter recording. Thus, rest tachycardia could Cardiac echo-Doppler investigations were performed be related to anxiety. Patient 6 did not perform exercise, on patients with asymmetric hypertrophic cardiomyopabecause of a very high rest obstruction (>150 mmHg). In thy (septum/posterior wall thickness >I S). Subaortic all patients who performed the stress test, tolerance was flow velocity was first recorded at rest in the left lateral position. Outflow gradients were estimated from the good, without ventricular arrhythmias. After disopyramide administration, left ventricular pressure gradient peak velocities by Bernoulli’s formula: pressure gradient = 4 (velocity2). A submaximal dynamic exercise was significantly decreased at rest (p
Hypertrophic
Cardiomyopathy
Alain Millaire, MD, Luc Goullard, MD, Eric Decoulx, MD, Pascal de Groote, MD, Yvon Houdas, MD, and Gdrard Ducloux, MD isopyramide is thought to be efficient in treating most casesof hypertrophic cardiomyopathy.’ CliniD cal symptoms, hemodynamic data at rest, and exercise
(EMIT-ABBOTT@--therapeutic range 2 to 5 rig/ml). Student’s paired t test was used for statistical analysis. Nine patients were included in this open study (Table duration are improved by disopyramide.‘-2However, he- I). All patients had a significant obstruction: at rest in 7, modynamic effects of a particular treatment can be dif- and during exercise in 2 (nos. 7 and 8). All patients were ferent at rest and during exercise.Thus, propranolol has in sinus rhythm. Eight patients were in New York Heart little effect on the intraventricular pressure gradient at Association functional class I or II, and 1 was in class III rest, but may diminish the increment that occurs with (patient 9). Patient 3 did not perform exercise, because exercise.3No data are available concerning the hemody- of dyspnea, tachycardia and rest obstruction. Tachycardia rapidly disappeared after hospital discharge, as namic efficiency of disopyramide during exercise. shown by Holter recording. Thus, rest tachycardia could Cardiac echo-Doppler investigations were performed be related to anxiety. Patient 6 did not perform exercise, on patients with asymmetric hypertrophic cardiomyopabecause of a very high rest obstruction (>150 mmHg). In thy (septum/posterior wall thickness >I S). Subaortic all patients who performed the stress test, tolerance was flow velocity was first recorded at rest in the left lateral position. Outflow gradients were estimated from the good, without ventricular arrhythmias. After disopyramide administration, left ventricular pressure gradient peak velocities by Bernoulli’s formula: pressure gradient = 4 (velocity2). A submaximal dynamic exercise was significantly decreased at rest (p
