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J Am Geriatr Soc. Author manuscript; available in PMC 2017 April 05. Published in final edited form as: J Am Geriatr Soc. 2016 April ; 64(4): 769–778. doi:10.1111/jgs.14049.

Effects of vitamin D3 supplementation on lean mass, muscle strength and bone mineral density during weight loss: A doubleblind randomized controlled trial

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Caitlin Mason, PhD1, Jean De Dieu Tapsoba, PhD1, Catherine Duggan, PhD1, Ikuyo Imayama, MD, PhD1, Ching-Yun Wang, PhD1,2, Larissa Korde, MD, MPH1,3, and Anne McTiernan, MD, PhD1,2 1Division 2School

of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA

of Public Health, University of Washington, Seattle, WA

3Department

of Medicine, University of Washington, Seattle, WA

Abstract Objectives—To compare 12 months of vitamin D3 supplementation versus placebo on lean mass, bone mineral density and muscle strength in overweight or obese postmenopausal women completing a structured weight-loss program. Design—Double-blind, placebo-controlled randomized clinical trial.

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Setting—Fred Hutchinson Cancer Research Center, Seattle, WA. Participants—218 postmenopausal (50-75 y) women, BMI ≥25 kg/m2, with serum 25hydroxyvitamin D (25(OH)D) concentrations ≥10 −