Int Urol Nephrol DOI 10.1007/s11255-015-0972-6
UROLOGY - ORIGINAL PAPER
Effects of oral testosterone undecanoate treatment for severe hypospadias Chao Chen1 · Chun‑xiu Gong2 · Wei‑ping Zhang1
Received: 13 February 2015 / Accepted: 31 March 2015 © Springer Science+Business Media Dordrecht 2015
Abstract Purpose We sought to evaluate the effects of oral testosterone undecanoate treatment based on the temporary growth of penis and the complications of surgery in children with microphallic hypospadias. Materials and methods A total of 72 randomized consecutive children with microphallic hypospadias were included in the study from March 2011 to September 2013. While 34 children were treated with oral testosterone undecanoate treatment prior to surgery on time (group 1), 36 children did not receive any treatment preoperatively (group 2). All children underwent hypospadias repair using transverse preputial island flap (Duckett technique) urethroplasty or combination of Duckett and Thiersch–Duplay techniques. Penile length, diameter, serum testosterone level, and secondary effects were recorded before and after therapy in group 1. Postoperative complications were assessed with respect to fistulas, urethral strictures, diverticula, meatal stenosis, and glanular dehiscence in both groups. Results Mean penile length and diameter increased significantly by 1.06 ± 0.53 cm (P 0.05). They had different degrees of ventral penile curvature: in group 1, 4 in 20°–30°, 24 in 30°–45°, 6 above 45° and in group 2, 3 in 20°–30°, 28 in 30°–45°, 5 above 45°. Patient’s characteristics for two groups are summarized in Table 3. A total of 70 patients in both groups underwent urethroplasty. Five patients in group 1 and three patients in group 2 underwent a combination of Duckett and Thiersch–Duplay technique, and the others underwent the Duckett procedure. The median operation time was 106.4 ± 8.9 min in group 1 and 124.8 ± 7.4 min in group 2 (P 0.05
0.664
>0.05
Table 4 Comparison of surgical complications in two groups Observations
Group 1
Group 2
Fistula Stricture Diverticulae Reoperation
2 0 3 5
9 3 3 14
χ2 4.825 1.277 0.005 5.171
P 0.05 >0.05
UROLOGY - ORIGINAL PAPER
Effects of oral testosterone undecanoate treatment for severe hypospadias Chao Chen1 · Chun‑xiu Gong2 · Wei‑ping Zhang1
Received: 13 February 2015 / Accepted: 31 March 2015 © Springer Science+Business Media Dordrecht 2015
Abstract Purpose We sought to evaluate the effects of oral testosterone undecanoate treatment based on the temporary growth of penis and the complications of surgery in children with microphallic hypospadias. Materials and methods A total of 72 randomized consecutive children with microphallic hypospadias were included in the study from March 2011 to September 2013. While 34 children were treated with oral testosterone undecanoate treatment prior to surgery on time (group 1), 36 children did not receive any treatment preoperatively (group 2). All children underwent hypospadias repair using transverse preputial island flap (Duckett technique) urethroplasty or combination of Duckett and Thiersch–Duplay techniques. Penile length, diameter, serum testosterone level, and secondary effects were recorded before and after therapy in group 1. Postoperative complications were assessed with respect to fistulas, urethral strictures, diverticula, meatal stenosis, and glanular dehiscence in both groups. Results Mean penile length and diameter increased significantly by 1.06 ± 0.53 cm (P 0.05). They had different degrees of ventral penile curvature: in group 1, 4 in 20°–30°, 24 in 30°–45°, 6 above 45° and in group 2, 3 in 20°–30°, 28 in 30°–45°, 5 above 45°. Patient’s characteristics for two groups are summarized in Table 3. A total of 70 patients in both groups underwent urethroplasty. Five patients in group 1 and three patients in group 2 underwent a combination of Duckett and Thiersch–Duplay technique, and the others underwent the Duckett procedure. The median operation time was 106.4 ± 8.9 min in group 1 and 124.8 ± 7.4 min in group 2 (P 0.05
0.664
>0.05
Table 4 Comparison of surgical complications in two groups Observations
Group 1
Group 2
Fistula Stricture Diverticulae Reoperation
2 0 3 5
9 3 3 14
χ2 4.825 1.277 0.005 5.171
P 0.05 >0.05
