Peter
W Jannace,
Robert
ABSTRACT
A dietary
soy phosphatidylcholine nuclear
(PMNL)
AA release, in normal
PC (27 g) or placebo with PMNL assays Subjects safflower
were (SF,
assays at phagocytosis PMNL
acid
(LA)
arachidonate
(AA)
AA content
(P
threefold
stimulation (r = 0.932)
but not 1 . With
SF
LTB4
triglyceride
LA,
and
generation.
enhanced
con-
Am
killing.
Study
LA,
phospholipid
mentation, The PC LA and
kotriene
Polymorphonuclear acid, arachidonic acid,
leukocyte, phagocytosis,
Candida killing,
alleu-
and
In four
dietary safflower
(LA,
nutrient.
1 8:2n-6),
It is the
oil (SF)
and
principal
soy bean
to be immunosuppressive animals ( 1-9). oils on immune
an w-6 fatty polyunsaturated oil (SY),
in studies
which
of phospholipids.
Thus,
effects
supplement
of an oral
kocyte achidonic (LTB4)
(PMNL) acid generation
Am J C/in Nuir
fatty
acid
been
shown
humans
the
it was
a significant Western
in and
of interest of LA
to study
(AA)
content from
and
release,
stimulated
1992;S6:599-603.
and
Printed
and
=
18 g noodles
blood
above
samples were
different
(P
0.2)
>
(n
from
added
were
the
four
PC,
each
to
SF, or SY blood
The
individuals they
18
added
In this experiment
because
sup-
of either
h postingestion.
from
pooled
and feeding
y of age,
feeding
4), which
=
were
at 48
taken
fed SY
23-63
a single
1.2 kJ/serving.
four
14 d after
at 48 h postingestion
females,
to which and
the
subjects
in a single
and
no
before
PMNLs.
with
4) or SY
at baseline
Signed
three
were
results fed SF
not
statis-
other.
protocol informed-consent
forms
jects in accordance with the ethical Review Board for Human Research,
were
obtained
standards Boston
from
all sub-
ofthe Institutional University Medical
Center.
the
killing),
From the Department of Pathology and Nutrition Pathology Unit, Mallory Institute of Pathology: the Clinical Nutrition Unit, Evans Memorial Department ofClinical Research and Preventive Medicine, University Hospital: and the Boston University School ofMedicine, Boston. 2 Supported in part by the Boston University School of Medicine. 3 Reprints not available. Received November 12, 1991. Accepted for publication March 26, 1992.
relative of major leu-
PMNL
on leukotriene
arB4
PMNLs. in USA.
the the
ingestion
diets
provided
drawn
at 4, 7, and ofthe
stimulated
and
normal
12 g LA and
drawn
PL
was
then
servings
source of dietary is in the form
as a component
(phagocytosis
males
provided
Experimental
of these
fat; ie, phospholipids as phosphatidylcholine fats as SF and SY on polymorphonuclear functions
their The
tically
effects of dietary host defenses (eg,
diet
2. Five
noodles.
and
or phagocytosis) have used neutral fats (ie, as the major or sole component ofthe lipid
in addition to oils, in the conventional
sources of dietary (PC) and neutral
both
is an essential
that the effects through LA.
Most of the studies that have examined lipids on immune functions or nonspecific
used. However, fat consumed
have
involving
It is reasonable to assume functions are mediated
response to mitogen triglycerides or oils)
acid,
before from
1 5 g SF (n
from acid
drawn
g PC or
was
Introduction Linoleic
was
to
five individuals without supple-
18 g PC was administered
generation
for 3
soup
divided
1 .5 kJ/d.
sample
supplements
plemented
B4, humans
blood
supplements.
blood
two
diets
noodle
in three
were reversed. 18 g LA and
A fasting
hiatus,
or
design. Initially, a 2-wk period
ofthe
for LTB4
l992;56:599-603.
given
of the
and
phagocy-
(PL)
initiation a 2-wk
and
normal
The PC was 95% PC choline and its fatty acid composition is mdi-
ingestion after
to
kJ/d.
six males their
placebo
crossover PL. After
the groups provided
0.5
volunteers,
I. PL or PC was
for 3 d in an open fed PC and three
Study KEY WORDS bicans, linoleic
adult
supplemented
a noodle-soup
in Table
daily were
AA
in contrast AA,
either
cated
increased 5.3-fold, and phagocytosis (r
Phospholipid
healthy y ofage,
which 27 g soy PC was added. 5% lysophosphatidylcholine;
PMNL 0.001)