EXPERIMENTAL AND THERAPEUTIC MEDICINE 7: 1349-1353, 2014
Effects of metformin on endothelial function in type 2 diabetes SONGLIN WU1, XIAOYAN LI2* and HONGMING ZHANG2* 1
Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060; 2Department of Cardiology, Jinan Military General Hospital, Jinan, Shandong 250031, P.R. China Received September 22, 2013; Accepted January 27, 2014 DOI: 10.3892/etm.2014.1582
Abstract. The aim of the present study was to examine the effect of metformin on endothelial function in patients with type 2 diabetes mellitus (T2DM). In total, 93 patients with T2DM and dissatisfactory glycemic control were randomly assigned to the metformin and pioglitazone groups and changes in vascular endothelial function were subsequently observed. Blood sugar levels and the insulin resistance (IR) index of the patients prior to treatment were lower than those following 12 months of treatment. In addition, fasting and postprandial insulin levels and the insulin function index were higher compared with those obtained following 12 months of treatment (P
Effects of metformin on endothelial function in type 2 diabetes SONGLIN WU1, XIAOYAN LI2* and HONGMING ZHANG2* 1
Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060; 2Department of Cardiology, Jinan Military General Hospital, Jinan, Shandong 250031, P.R. China Received September 22, 2013; Accepted January 27, 2014 DOI: 10.3892/etm.2014.1582
Abstract. The aim of the present study was to examine the effect of metformin on endothelial function in patients with type 2 diabetes mellitus (T2DM). In total, 93 patients with T2DM and dissatisfactory glycemic control were randomly assigned to the metformin and pioglitazone groups and changes in vascular endothelial function were subsequently observed. Blood sugar levels and the insulin resistance (IR) index of the patients prior to treatment were lower than those following 12 months of treatment. In addition, fasting and postprandial insulin levels and the insulin function index were higher compared with those obtained following 12 months of treatment (P
