Aquatic Toxicology 152 (2014) 318–323

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Aquatic Toxicology journal homepage: www.elsevier.com/locate/aquatox

Effects of metal nanoparticles on the lateral line system and behaviour in early life stages of zebrafish (Danio rerio) Paul L. McNeil a,∗ , David Boyle b , Theodore B. Henry c,d , Richard D. Handy b , Katherine A. Sloman a a

Institute of Biomedical and Environmental Health Research, School of Science, University of the West of Scotland, Paisley, UK Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological, Sciences, University of Plymouth, Devon, UK c School of Life Sciences, Heriot-Watt University, Edinburgh, UK d Department of Forestry Wildlife and Fisheries, and Center for Environmental Biotechnology, The University of Tennessee, Knoxville, TN 37996, USA b

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Article history: Received 30 October 2013 Received in revised form 4 April 2014 Accepted 19 April 2014 Available online 25 April 2014 Keywords: Copper Embryo Neuromast Rheotaxis Silver Titanium

a b s t r a c t The unique physicochemistry and potential toxicity of manufactured nanoparticles (NPs) requires innovative approaches for the assessment of toxicity to aquatic organisms. Here, the toxicity of Cu-NPs, Ag-NPs and TiO2 -NPs on the lateral line system of free-swimming zebrafish embryos was investigated and compared to appropriate metal salts or bulk material controls. Fish were exposed for 4 h at 96-h post-fertilization. Metal salt (CuSO4 and AgNO3 ) controls reduced the number of functional lateral line neuromasts (LLN) to

Effects of metal nanoparticles on the lateral line system and behaviour in early life stages of zebrafish (Danio rerio).

The unique physicochemistry and potential toxicity of manufactured nanoparticles (NPs) requires innovative approaches for the assessment of toxicity t...
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