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Effects of different rhBMP-2 release profiles in defect areas around dental implants on bone regeneration
This content has been downloaded from IOPscience. Please scroll down to see the full text. 2015 Biomed. Mater. 10 045007 (http://iopscience.iop.org/1748-605X/10/4/045007) View the table of contents for this issue, or go to the journal homepage for more
Download details: IP Address: 146.201.32.11 This content was downloaded on 01/07/2016 at 03:36
Please note that terms and conditions apply.
Biomed. Mater. 10 (2015) 045007
doi:10.1088/1748-6041/10/4/045007
Paper
received
4 February 2015
Effects of different rhBMP-2 release profiles in defect areas around dental implants on bone regeneration
re vised
25 April 2015 accep ted for publication
15 May 2015 published
13 July 2015
Jae Ho Jo1,4, Sung Wook Choi2,4, Jae Won Choi1, Dong Hyun Paik2, Seong Soo Kang3, Se Eun Kim3, Yong-Chan Jeon1 and Jung Bo Huh1 1
Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, YangSan, 676–870, Korea 2 Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420–743, Korea 3 Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju, 500–757, Korea E-mail: [email protected] Keywords: release profile, rhBMP-2, implant, osseointegration, bone formation
Abstract This study was undertaken to evaluate the effects of different rhBMP-2 release profiles in defect areas around dental implants on osseointegration and bone regeneration. Four beagle dogs (13–15 kg) were used. The defect was 3 mm deep and there was a 1 mm gap around the implant. Each of the four implants was installed on the right and left mandibular alveolar ridges. After the implants were placed, experimental groups were applied to the surrounding defect area (n = 8 in each group, the control group was not treated). The inject group was injected with rhBMP-2 solution directly. In the gel group, rhBMP-2 mixed with a hydrogel matrix was applied. In the particle–gel group, rhBMP2-embedded poly(lactic-co-glycolic acid)(PLGA) microparticles mixed with hydrogel matrix were applied to maintain consistent release. Sequential fluorescent labeling and histological analysis were performed to evaluate the new bone formation and osseointegration in the defect area. In the control group, larger marginal bone loss was detected as compared with the other groups (P
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Journals
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My IOPscience
Effects of different rhBMP-2 release profiles in defect areas around dental implants on bone regeneration
This content has been downloaded from IOPscience. Please scroll down to see the full text. 2015 Biomed. Mater. 10 045007 (http://iopscience.iop.org/1748-605X/10/4/045007) View the table of contents for this issue, or go to the journal homepage for more
Download details: IP Address: 146.201.32.11 This content was downloaded on 01/07/2016 at 03:36
Please note that terms and conditions apply.
Biomed. Mater. 10 (2015) 045007
doi:10.1088/1748-6041/10/4/045007
Paper
received
4 February 2015
Effects of different rhBMP-2 release profiles in defect areas around dental implants on bone regeneration
re vised
25 April 2015 accep ted for publication
15 May 2015 published
13 July 2015
Jae Ho Jo1,4, Sung Wook Choi2,4, Jae Won Choi1, Dong Hyun Paik2, Seong Soo Kang3, Se Eun Kim3, Yong-Chan Jeon1 and Jung Bo Huh1 1
Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, YangSan, 676–870, Korea 2 Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si, Gyeonggi-do, 420–743, Korea 3 Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju, 500–757, Korea E-mail: [email protected] Keywords: release profile, rhBMP-2, implant, osseointegration, bone formation
Abstract This study was undertaken to evaluate the effects of different rhBMP-2 release profiles in defect areas around dental implants on osseointegration and bone regeneration. Four beagle dogs (13–15 kg) were used. The defect was 3 mm deep and there was a 1 mm gap around the implant. Each of the four implants was installed on the right and left mandibular alveolar ridges. After the implants were placed, experimental groups were applied to the surrounding defect area (n = 8 in each group, the control group was not treated). The inject group was injected with rhBMP-2 solution directly. In the gel group, rhBMP-2 mixed with a hydrogel matrix was applied. In the particle–gel group, rhBMP2-embedded poly(lactic-co-glycolic acid)(PLGA) microparticles mixed with hydrogel matrix were applied to maintain consistent release. Sequential fluorescent labeling and histological analysis were performed to evaluate the new bone formation and osseointegration in the defect area. In the control group, larger marginal bone loss was detected as compared with the other groups (P
