Vaccine 33 (2015) 1440–1445

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Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients Yoshihiko Kawano a , Michio Suzuki a , Jun-ichi Kawada a , Hiroshi Kimura b , Hideya Kamei c , Yasuharu Ohnishi c , Yasuyuki Ono d , Hiroo Uchida d , Yasuhiro Ogura c , Yoshinori Ito a,∗ a

Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan c Department of Transplantation Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan d Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan b

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Article history: Received 20 August 2014 Received in revised form 25 January 2015 Accepted 27 January 2015 Available online 7 February 2015 Keywords: Immunization Live-attenuated vaccine Inactivated vaccine Children Liver transplantation

a b s t r a c t Background: Liver transplantation recipients are at high risk for severe complications due to infections because of being treated with immunosuppressive drugs that affect the immune system. Vaccination for liver transplantation candidates is generally recommended before surgery, but the opportunities for vaccination prior to transplantation in pediatric candidates are often limited by severe disease conditions. Methods: The participants in this study comprised 39 pediatric recipients of living donor liver transplantation performed between 2005 and 2013. Criteria for administering live-attenuated (measles, rubella, mumps, and varicella) and inactivated (hepatitis B, pertussis, and Japanese encephalitis) vaccines were as follows: (1) >1 year after transplantation; (2) no use of systemic steroids to treat acute rejection within the last 6 months; (3) serum trough concentration of tacrolimus 1 year after transplantation and stable general condition; (2) no use of systemic steroids to treat acute rejection within the last 6 months; (3) exclusive use of tacrolimus as an immunosuppressive drug, and serum trough concentration of tacrolimus

Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients.

Liver transplantation recipients are at high risk for severe complications due to infections because of being treated with immunosuppressive drugs tha...
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