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Pediatr Obes. Author manuscript; available in PMC 2017 August 01. Published in final edited form as: Pediatr Obes. 2016 August ; 11(4): 279–284. doi:10.1111/ijpo.12059.

Effect of Vitamin D3 Treatment on Endothelial Function in Obese Adolescents A Javed, MBBS1, I. J. Kullo, M.D2, P. Babu Balagopal, PhD3, and S Kumar, MD1 1Division

of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA

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2Division

of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA

3Nemours

Children’s Clinic, Division of Biomedical Research, Jacksonville, FL, USA

Abstract Background—Obesity in children is associated with vitamin D deficiency and endothelial dysfunction. It is not known if treatment with vitamin D improves endothelial function in obese adolescents. Objective—To determine whether treatment with vitamin D3 improves endothelial function in obese adolescents.

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Methods—Nineteen obese adolescents, 13–18 years of age, with 25-hydroxy vitamin D (25(OH)D) levels < 75 nmol/L were treated with 100,000 IU vitamin D3 orally once a month for 3 months in an open-label, single-center prospective trial. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at study entry and 1 month after the 3rd dose of vitamin D3. Biochemical parameters, including calcium, fasting lipids, glucose, insulin, and high-sensitivity C-reactive protein were also obtained. Results—Mean 25(OH)D levels increased from 55.9±12.2 nmol/L to 86.9±16.7 nmol/L (P