Effect of Vagus Nerve Stimulation Upon Excitabil *,I ty of the Canine Ventricle Role of Sympathetic-Parasympathetic
BENET S KOLMAN, MD PhD RICHARD L VERRIER, BERNARD LOWN, MD, FACC Boston, Massachusetts
From the Cardrovascular Research Laboratones, Department of Nutrltlon, Harvard School of Public Health, Boston, Mass Thus study was supported W-Ipart by Grants MH-21384 from the NatIonal Instatute of Mental Health and H4-07776 and HL05242 from the Natlonal Heart and Lung lnstltute of the National Institutes of Health, Bethesda. Md Manuscript accepted October 1, 1975 Address for reprints Bernard Lown, MD, Department of Nutrihon. Harvard School of Public Health, 665 HuntIngton Ave , Boston, Mass 02115
Interactions
The effect of vagus nerve stimulation on ventricular excitability was studied in 28 dogs under various conditions of adrenergic neural tone. Strength-interval curves were delineated from the apex of the right ventricular endocardium with a transvenous bipolar catheter. Vagus nerve stimulation in both closed chest and open chest dogs shifted the strength-interval curve 6 to 8 msec later into electrical diastole (P
BENET S KOLMAN, MD PhD RICHARD L VERRIER, BERNARD LOWN, MD, FACC Boston, Massachusetts
From the Cardrovascular Research Laboratones, Department of Nutrltlon, Harvard School of Public Health, Boston, Mass Thus study was supported W-Ipart by Grants MH-21384 from the NatIonal Instatute of Mental Health and H4-07776 and HL05242 from the Natlonal Heart and Lung lnstltute of the National Institutes of Health, Bethesda. Md Manuscript accepted October 1, 1975 Address for reprints Bernard Lown, MD, Department of Nutrihon. Harvard School of Public Health, 665 HuntIngton Ave , Boston, Mass 02115
Interactions
The effect of vagus nerve stimulation on ventricular excitability was studied in 28 dogs under various conditions of adrenergic neural tone. Strength-interval curves were delineated from the apex of the right ventricular endocardium with a transvenous bipolar catheter. Vagus nerve stimulation in both closed chest and open chest dogs shifted the strength-interval curve 6 to 8 msec later into electrical diastole (P
