Research Article

Effect of trapidil in myocardial ischemia‑reperfusion injury in rabbit MingJie Liu1,2, Qi Sun1,3, Qiang Wang3, Xiuying Wang4, Peng Lin4, Ming Yang4, Yuanyuan Yan4

ABSTRACT Objectives: To evaluate the cardioprotective effects of trapidil on myocardial ischemia‑reperfusion injury (MIRI) in rabbits. Materials and Methods: Rabbits were subjected to 40 min of myocardial ischemia followed by 120 min of reperfusion. Blood for superoxide dismutase (SOD) and malondialdehyde (MDA) were estimated. At the end of reperfusion, the rabbits were sacrificed and the hearts were isolated for histological examination. An apoptotic index  (AI) was determined using the terminal deoxynucleotidyl transferase (TdT)‑mediated dUTP nick‑end‑labeling (TUNEL) method. The expression of apoptosis‑related proteins Bax and Bcl‑2 was analyzed using immunohistochemistry. Statistical analyses were performed by one‑way analysis of variance (ANOVA), P 

Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit.

To evaluate the cardioprotective effects of trapidil on myocardial ischemia-reperfusion injury (MIRI) in rabbits...
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