Original Article
http://dx.doi.org/10.3349/ymj.2013.54.6.1331 pISSN: 0513-5796, eISSN: 1976-2437
Yonsei Med J 54(6):1331-1335, 2013
Effect of Testosterone Replacement Therapy on Bone Mineral Density in Patients with Klinefelter Syndrome Dae Gi Jo,1 Hyo Serk Lee,1 Young Min Joo,2 and Ju Tae Seo1 Department of Urology, Cheil General Hospital, Kwandong University College of Medicine, Seoul; 2Daewoo General Hospital, Geoje, Korea.
1
Received: January 17, 2013 Revised: February 18, 2013 Accepted: March 13, 2013 Corresponding author: Dr. Ju Tae Seo, Department of Urology, Cheil General Hospital, Kwandong University College of Medicine, 17 Seoae-ro 1-gil, Jung-gu, Seoul 100-380, Korea. Tel: 82-2-2000-7585, Fax: 82-2-2000-7787 E-mail: [email protected] ∙ The authors have no financial conflicts of interest.
Purpose: Klinefelter syndrome (KS) is related to testicular insufficiency, which causes low testosterone levels in serum. Generally, sex hormone levels and bone mineral density (BMD) are lower in patients with KS than normal. We investigated the effects of testosterone replacement on serum testosterone levels and BMD in KS patients. Materials and Methods: From December 2005 to March 2008, 18 KS patients with a 47, XXY karyotype were treated with initial intramuscular injections of long-acting testosterone undecanoate (Nebido®, 1000 mg/4 mL) at baseline and second injections after six weeks. An additional four injections were administered at intervals of 12 weeks after the second injection. BMD was measured at the lumbar spine (L2-4), the left femoral neck and Ward’s triangle, using dual energy X-ray absorptiometry. Medical histories, physical examinations and prostate specific antigen, hematology and serum chemistry were conducted for each patient. In addition, total testosterone and sex hormone-binding globulin levels were measured. Results: Following testosterone replacement, mean serum total testosterone increased significantly from baseline (0.90 vs. 4.51 ng/mL, p
http://dx.doi.org/10.3349/ymj.2013.54.6.1331 pISSN: 0513-5796, eISSN: 1976-2437
Yonsei Med J 54(6):1331-1335, 2013
Effect of Testosterone Replacement Therapy on Bone Mineral Density in Patients with Klinefelter Syndrome Dae Gi Jo,1 Hyo Serk Lee,1 Young Min Joo,2 and Ju Tae Seo1 Department of Urology, Cheil General Hospital, Kwandong University College of Medicine, Seoul; 2Daewoo General Hospital, Geoje, Korea.
1
Received: January 17, 2013 Revised: February 18, 2013 Accepted: March 13, 2013 Corresponding author: Dr. Ju Tae Seo, Department of Urology, Cheil General Hospital, Kwandong University College of Medicine, 17 Seoae-ro 1-gil, Jung-gu, Seoul 100-380, Korea. Tel: 82-2-2000-7585, Fax: 82-2-2000-7787 E-mail: [email protected] ∙ The authors have no financial conflicts of interest.
Purpose: Klinefelter syndrome (KS) is related to testicular insufficiency, which causes low testosterone levels in serum. Generally, sex hormone levels and bone mineral density (BMD) are lower in patients with KS than normal. We investigated the effects of testosterone replacement on serum testosterone levels and BMD in KS patients. Materials and Methods: From December 2005 to March 2008, 18 KS patients with a 47, XXY karyotype were treated with initial intramuscular injections of long-acting testosterone undecanoate (Nebido®, 1000 mg/4 mL) at baseline and second injections after six weeks. An additional four injections were administered at intervals of 12 weeks after the second injection. BMD was measured at the lumbar spine (L2-4), the left femoral neck and Ward’s triangle, using dual energy X-ray absorptiometry. Medical histories, physical examinations and prostate specific antigen, hematology and serum chemistry were conducted for each patient. In addition, total testosterone and sex hormone-binding globulin levels were measured. Results: Following testosterone replacement, mean serum total testosterone increased significantly from baseline (0.90 vs. 4.51 ng/mL, p
