BIOMEDICAL REPORTS 4: 59-62, 2016

Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice RUNLEI HU1, SHENGLIN MA2, XIANFU KE3, HONG JIANG1, DONGSHAN WEI1 and WEI WANG1 Departments of 1Thoracic Surgery and 2Radiation Oncology, Hangzhou First People's Hospital, Nanjing Medical University; 3 Laboratory Animal Center, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang 310006, P.R. China Received August 17, 2015; Accepted October 16, 2015 DOI: 10.3892/br.2015.540 Abstract. The present study aimed to investigate the therapeutic effect of interleukin‑2 (IL‑2) treatment combined with magnetic fluid hyperthermia (MFH) on Lewis lung cancer‑bearing mice. Magnetic fluids were prepared in vitro and directly injected into the tumors in the mice, which were subjected to an alternating magnetic field. The temperature in the tumor reached 43˚C and was maintained by controlling the strength of magnetic field for 30 min. Twenty‑four hours later, IL‑2 was injected directly into the tumors. Mice were divided into four groups: Group I (control), II (MFH), III (IL‑2) and IV (IL‑2+MFH). The tumor grew gradually in groups II and IV (both P

Effect of interleukin-2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer-bearing mice.

The present study aimed to investigate the therapeutic effect of interleukin-2 (IL-2) treatment combined with magnetic fluid hyperthermia (MFH) on Lew...
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