Original Research Paper
Effect of hydro-alcoholic extract of Rosa damascena on cardiovascular responses in normotensive rat Amir Baniasad1, Abolfazl Khajavirad1, Mahmoud Hosseini2, Mohammad Naser Shafei*3, Saeed Aminzadah4, Mahmoud Ghavi1 1
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Iran Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Iran 3 Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 4 Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Article history: Abstract Received: Aug 2, 2014 Objective: Rosa damascena mill L. (R. damascena) is a wellReceived in revised form: known plant with fragrant effects. Several therapeutic effects of Feb 5, 2015 this plant on respiratory, gastrointestinal and nervous systems Accepted: Apr 12, 2015 have been reported. It is also suggested to have beneficial Vol. 5, No. 4, Jul-Aug 2015, 319effect on cardiovascular system especially blood pressure 324. 2
* Corresponding Author: Tel: +985138002230 Fax: +985138828564 E-mail: [email protected] Keywords: Rosa damascena Blood pressure Heart rate Rat
regulation. The present study was carried out to evaluate acute cardiovascular effect of hydro-alcoholic extract of R. damascena. Materials and Methods: Thirty-two male Wistar rats were randomly divided into four groups (n= 8 for each group). After anesthesia, a catheter was inserted into the femoral artery and blood pressure and heart rate (HR) were continuously recorded by a power lab system. Animals received three doses of hydroalcoholic extract (250, 500, and 1000 mg/kg) via peritoneal (i.p). After 30 min, systolic blood pressure (SBP), mean arterial pressure (MAP) and HR were recorded and maximal changes were compared to control group. Results: Injection of all doses of the extract did not significantly change HR compare to control group. The SBP, dose dependently, was decreased by all doses of the extract and the maximal response was significant compared to saline group (p
Effect of hydro-alcoholic extract of Rosa damascena on cardiovascular responses in normotensive rat Amir Baniasad1, Abolfazl Khajavirad1, Mahmoud Hosseini2, Mohammad Naser Shafei*3, Saeed Aminzadah4, Mahmoud Ghavi1 1
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Iran Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Iran 3 Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 4 Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Article history: Abstract Received: Aug 2, 2014 Objective: Rosa damascena mill L. (R. damascena) is a wellReceived in revised form: known plant with fragrant effects. Several therapeutic effects of Feb 5, 2015 this plant on respiratory, gastrointestinal and nervous systems Accepted: Apr 12, 2015 have been reported. It is also suggested to have beneficial Vol. 5, No. 4, Jul-Aug 2015, 319effect on cardiovascular system especially blood pressure 324. 2
* Corresponding Author: Tel: +985138002230 Fax: +985138828564 E-mail: [email protected] Keywords: Rosa damascena Blood pressure Heart rate Rat
regulation. The present study was carried out to evaluate acute cardiovascular effect of hydro-alcoholic extract of R. damascena. Materials and Methods: Thirty-two male Wistar rats were randomly divided into four groups (n= 8 for each group). After anesthesia, a catheter was inserted into the femoral artery and blood pressure and heart rate (HR) were continuously recorded by a power lab system. Animals received three doses of hydroalcoholic extract (250, 500, and 1000 mg/kg) via peritoneal (i.p). After 30 min, systolic blood pressure (SBP), mean arterial pressure (MAP) and HR were recorded and maximal changes were compared to control group. Results: Injection of all doses of the extract did not significantly change HR compare to control group. The SBP, dose dependently, was decreased by all doses of the extract and the maximal response was significant compared to saline group (p
