RESEARCH ARTICLE
Effect of Gender, Disease Duration and Treatment on Muscle Strength in Myasthenia Gravis Gu¨lsenay Citirak1, Sanja Cejvanovic1, Henning Andersen2, John Vissing1* 1 Neuromuscular Research Unit, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 2 Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
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* [email protected]
Abstract Introduction OPEN ACCESS Citation: Citirak G, Cejvanovic S, Andersen H, Vissing J (2016) Effect of Gender, Disease Duration and Treatment on Muscle Strength in Myasthenia Gravis. PLoS ONE 11(10): e0164092. doi:10.1371/ journal.pone.0164092 Editor: Aldrin V. Gomes, University of California, Davis, UNITED STATES Received: October 16, 2015 Accepted: September 20, 2016 Published: October 14, 2016 Copyright: © 2016 Citirak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Data underlying this study cannot be made publicly available due to patient privacy and sensitive health data according to the Danish Health Data Authority. The authors confirm that a de-identified dataset will be made available upon request from the Research Center for Neuromuscular diseases (https://www. rigshospitalet.dk/afdelinger-og-klinikker/neuro/ neurologiskklinik/neuromuskulaerforskningsenhed/). Data requests can be sent to Dr. John Vissing ([email protected]).
The aim of this observational, cross-sectional study was to quantify the potential presence of muscle weakness among patients with generalized myasthenia gravis (gMG). The influence of gender, treatment intensity and disease duration on muscle strength and disease progression was also assessed.
Methods Muscle strength was tested in 8 muscle groups by manual muscle testing and by hand-held dynamometry in 107 patients with gMG and 89 healthy age- and gender-matched controls. Disease duration, severity and treatment history were reviewed and compared with muscle strength.
Results Patients had reduced strength in all tested muscle group compared to control subjects (p
Effect of Gender, Disease Duration and Treatment on Muscle Strength in Myasthenia Gravis Gu¨lsenay Citirak1, Sanja Cejvanovic1, Henning Andersen2, John Vissing1* 1 Neuromuscular Research Unit, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 2 Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
a11111
* [email protected]
Abstract Introduction OPEN ACCESS Citation: Citirak G, Cejvanovic S, Andersen H, Vissing J (2016) Effect of Gender, Disease Duration and Treatment on Muscle Strength in Myasthenia Gravis. PLoS ONE 11(10): e0164092. doi:10.1371/ journal.pone.0164092 Editor: Aldrin V. Gomes, University of California, Davis, UNITED STATES Received: October 16, 2015 Accepted: September 20, 2016 Published: October 14, 2016 Copyright: © 2016 Citirak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Data underlying this study cannot be made publicly available due to patient privacy and sensitive health data according to the Danish Health Data Authority. The authors confirm that a de-identified dataset will be made available upon request from the Research Center for Neuromuscular diseases (https://www. rigshospitalet.dk/afdelinger-og-klinikker/neuro/ neurologiskklinik/neuromuskulaerforskningsenhed/). Data requests can be sent to Dr. John Vissing ([email protected]).
The aim of this observational, cross-sectional study was to quantify the potential presence of muscle weakness among patients with generalized myasthenia gravis (gMG). The influence of gender, treatment intensity and disease duration on muscle strength and disease progression was also assessed.
Methods Muscle strength was tested in 8 muscle groups by manual muscle testing and by hand-held dynamometry in 107 patients with gMG and 89 healthy age- and gender-matched controls. Disease duration, severity and treatment history were reviewed and compared with muscle strength.
Results Patients had reduced strength in all tested muscle group compared to control subjects (p
