Clin Chem Lab Med 2015; 53(2): e29–e31

Letter to the Editor Rafael Alis*, Marco Romagnoli, Cristina Primo-Carrau, Helios Pareja-Galeano, José R. Blesa and Fabián Sanchis-Gomar

Effect of exhaustive running exercise on red blood cell distribution width DOI 10.1515/cclm-2014-0749 Received July 20, 2014; accepted July 22, 2014; previously published online August 7, 2014

Keywords: exercise; mean corpuscular volume; red blood cell distribution width. To the Editor, Red blood cell distribution width (RDW) is a simple and inexpensive parameter, routinely reported by automated hematological analyzers, and conventionally used as a measure of anisocytosis. In recent years, there has been growing interest on RDW due to the fact that increased values are associated with a variety of pathological

*Corresponding author: Rafael Alis, Research Universitary Institute ‘Dr. Viña Giner’, Molecular and Mitochondrial Medicine, Catholic University of Valencia ‘San Vicente Mártir’, c/Quevedo 2, 46001 Valencia, Spain, Phone: +34 963637412, Fax: +34 963944590, E-mail: [email protected]; and Faculty of Medicine, Catholic University of Valencia ‘San Vicente Mártir’ Marco Romagnoli: Research Universitary Institute ‘Dr. Viña Giner’, Molecular and Mitochondrial Medicine, Catholic University of Valencia ‘San Vicente Mártir’, Valencia, Spain; and Department of Physical Education and Sports, Catholic University of Valencia ‘San Vicente Mártir’, Valencia, Spain Cristina Primo-Carrau: Research Universitary Institute ‘Dr. Viña Giner’, Molecular and Mitochondrial Medicine, Catholic University of Valencia ‘San Vicente Mártir’, Valencia, Spain Helios Pareja-Galeano: Department of Physiology, University of Valencia, Valencia, Spain; and Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain José R. Blesa: Research Universitary Institute ‘Dr. Viña Giner’, Molecular and Mitochondrial Medicine, Catholic University of Valencia ‘San Vicente Mártir’, Valencia, Spain; and Faculty of Medicine, Catholic University of Valencia ‘San Vicente Mártir’, Valencia, Spain Fabián Sanchis-Gomar: Research Universitary Institute ‘Dr. Viña Giner’, Molecular and Mitochondrial Medicine, Catholic University of Valencia ‘San Vicente Mártir’, Valencia, Spain; Department of Physiology, University of Valencia, Valencia, Spain; and Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain

conditions and increased mortality risk [1], as well as has been linked with aging [2]. Exercise is a physiological challenge that can alter circulating biomarkers by either affecting the concentration of the biomarker or inducing hemoconcentration [3, 4]. A previous study showed that RDW values are not affected by endurance running in altitude [5]. Nevertheless, the effect of acute exhaustive exercise on RDW has not been explored so far to the best of our knowledge. To investigate this issue, 30 healthy male subjects (aged 20–45 years, body mass index: 23.17 ± 1.87 kg/m2) performed an incremental test to exhaustion in a motorized treadmill. Of them, 20 were physically active (trained group, triathletes and endurance athletes who practiced physical activity weekly  > 12 h) whilst 10 were physically inactive (sedentary group, weekly physical activity   1.1; 2) maximal heart rate  > maximal heart rate predicted as 220-age. All test met this criteria. Blood samples were taken from the antecubital vein before, just after exercise and after the 30-min recovery period (30′-recovery). Blood samples were collected in standard Vacutainer® tubes containing K3EDTA. Tubes were kept in ice until performing determinations within 2 h after extraction. No sample got frozen as result of ice keeping.

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e30      Alis et al.: Exercise and RDW

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Figure 1 Red blood cell distribution width (RDW) median values before and after exercise and after 30′-recovery. Exhaustive running exercise had effect on RDW [χ2(2) = 25.613; p 

Effect of exhaustive running exercise on red blood cell distribution width.

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