Accepted Article

The effect of endurance training on expiratory flow limitation and dynamic hyperinflation in patients with stable chronic obstructive pulmonary disease

1

Rui Chen1, MD, Rongchang Chen2*, BS, Xin Chen3, MD, Lian Chen,4 BS

1

Department of Respiratory diseases, SUN Yat-sen memorial hospital, SUN Yat-sen University, Guangzhou 510120, China

2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of

Guangzhou Medical University, Guang Zhou 510012, China

3 Department of Respiratory Medicine, Zhu Jiang Hospital of Southern Medical University, Guang Zhou 510280, China

4

Medical Examination Center, Guangdong Provincial Hospital, Guangzhou 510055, China

Contributions to the manuscript

Conceived and designed the experiments: Rui CHEN,Rong-chang CHEN.

Performed the experiments: Rui CHEN,Xin CHEN,Lian CHEN.

Analyzed the data: Rui CHEN,Xin CHEN.

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/imj.12483

This article is protected by copyright. All rights reserved.

Accepted Article

Contributed materials/analysis tools: Rong-chang CHEN.

Wrote the paper: Rui CHEN.

Email Addresses Rui CHEN ([email protected])

Rong-chang Chen ([email protected])

Lian CHEN ([email protected]) Xin Chen ([email protected]) *, Corresponding author: State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guang Zhou 510012, China

Tel: +86-13902273260 Fax: +86-021-64085875 Email: [email protected] Running title: Chronic obstructive pulmonary disease

This article is protected by copyright. All rights reserved.

Accepted Article

Abstract Objective To determine the effects of endurance training on expiratory flow limitation (EFL) and dynamic hyperinflation in patients with stable COPD. Methods This was a prospective, single-blinded, non-randomized controlled 12-week study recruiting Chinese patients with stable COPD in an endurance training group (n=15)

or a control group (n=13). Before and at the study end, we measured the EFL, pulmonary function, peak inspiratory flow (PIF) and maximum inspiratory pressure (MIP); moreover, the patients underwent a constant work rate exercise test in which Borg dyspnea scale, tidal breathing flow volume curves and inspiratory capacity (IC) were determined every other minute. Results

Exercise training significantly improved the exercise endurance time (7.00±3.05 vs

18.13±6.44 min, P

Effect of endurance training on expiratory flow limitation and dynamic hyperinflation in patients with stable chronic obstructive pulmonary disease.

Expiratory flow limitation (EFL) is the primary pathophysiological hallmark of chronic obstructive pulmonary disease (COPD). However, the effect of lo...
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