Scandinavian Journal of Clinical and Laboratory Investigation

ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20

Effect of calcium on oxalate uptake and transport by the rat intestine V. Sharma & P. O. Schwille To cite this article: V. Sharma & P. O. Schwille (1992) Effect of calcium on oxalate uptake and transport by the rat intestine, Scandinavian Journal of Clinical and Laboratory Investigation, 52:4, 339-346, DOI: 10.1080/00365519209088367 To link to this article: http://dx.doi.org/10.1080/00365519209088367

Published online: 29 Mar 2011.

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Date: 02 April 2016, At: 06:05

Scand J Clin Lab Invest 1992: 52: 339-346

Effect of calcium on oxalate uptake and transport by the rat intestine V . S H A R M A & P. 0. S C H W I L L E

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Division of Experimental Surgery and Endocrine Research Laboratory, Department of Surgery, University of Erlangen, Germany

Sharma V, Schwille PO. Effect of calcium on oxalate uptake and transport by the rat intestine. Scand J Clin Lab Invest 1992; 52: 339-346. The effect of calcium concentration (0-10 mmol I-') on oxalate uptake and transport was investigated in vitro using everted gut segments and sacs. Increase in calcium concentration in the incubation medium led to an increase in the amounts of precipitated oxalate on the intestine; however, the net oxalate flux to the serosal side decreased. The ions, i.e. Ca2+, Ox2-, H2P04-, HP042-, present in the incubation medium favoured formation of hydroxyapatite and calcium oxalate crystals, as evidenced by Equil I1 analysis and free energy of the system. The nature of precipitates was confirmed by elemental analysis, X-ray diffraction spectrometry and electron microscopy. Oxalate precipitated on the intestine following incubation with calcium could be released into a calciumand oxalate-free medium. Animals fed oxalate in the absence and presence of calcium revealed that, during 1 h in the absence of calcium, oxalate moved down the intestinal tract as a distinct peak of >SO% (70-90 cm in the intestine), leaving

Effect of calcium on oxalate uptake and transport by the rat intestine.

The effect of calcium concentration (0-10 mmol 1(-1)) on oxalate uptake and transport was investigated in vitro using everted gut segments and sacs. I...
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