Jap. J. Physiol.,

EFFECT

OF

25, 575-584,

1975

A HIGH-FAT DIET ON METABOLIC RESPONSES TO EXERCISE 1

Akihiro KUROSHIMA, Tomie OHNO*,Osamu HAYAMI*,and Ikuko FUJITA* Departmentof Physiology,AsahikawaMedicalCollege,Asahikawa071-01 *Collegeof SchoolHealth, HokkaidoUniversity of Education,Asahikawa070, Japan Abstract

Effect

metabolic

responses

rats

was acid

32•Ž

produced

(SD)

and

at

SD

32•Ž at

either

32•Ž

groups,

levels

when

groups

in

fasting

tate

in

These

results

function

has

acids its

Received Supported 1

and

contribution

for publication in part

in

induced

extent

is not

less

evidence as the

March

total

fuel

energy

for

that muscular

requirements

There

and

and

after

was

not

exercise

in

HF

in in

blood

lac-

markedly

group. for

of

ketone

observed

was

response

indicating

a major

both group.

groups.

favorable

in

in HF

FFA

the

at in-

swimming

the

both

increments

production

in

increases

in

HF

not

levels

increment

and

necessarily

causes

lactate

serve

of

temperatures

18hr,

blood rest

blood in

increases

FFA

relation

of

it did

for

smaller

significant

the

HF

group

at a

rise

the

in

at diet

changes similar

state

free

standard

a greater

blood

in

blood

Swimming a

significant

was

such

rest.

on

30min

of

both

HF

calorie

for

showed

combined

while

feeding

to

fasting

were

substantial

could

the

between

lower

more

in

significantly

state,

that HF

no

increase

results

at

caused

increment

however,

suggest

25•Ž

correlation

Swimming

been

(FFA)

of

not

fed

swimming

bodies

There

although

the the

because

ketone

fatty

extent

concentrations,

greater

In

of

were

increases

by

25•Ž

at

FFA

while

25•Ž.

did

state.

at there

group,

positive

both the

or

body

significant

body

blood

fat

or

elevations

concentration

SD

50%

32•Ž

concentrations in

significant

the

ketone a

in

in

although

Blood

body

32•Ž

resulted

body

while

at

significant

Swimming

group,

25•Ž

containing

exercise

increases

ketone

and

(HF)

produced

ketone

groups.

Blood

was

HF and

in

diet

swimming

similar

HF

group.

crease

to

(FFA)

level

both

a high-fat

investigated.

fatty

FFA

of

the

blood to

lipid

exercise FFA

and

exercise.

in

work depends

the

form

(EKELUND, on

the

of

free

1969), severity

3, 1975

by a grant from Hokkaido,

No.2-10,

1973.

Part of this work has been presented at the 51th General Meeting of the Physiological Society of Japan (J. Physiol. Soc. Japan, 36:411-412, 1974).

黒 島 農 汎,大 野 都 美 恵*,速

水

修*,藤

田依 久子* 575

576

of

A. KUROSHIMA,

exercise,

ercise

from

of

and

low

PAUL,

1972; Fat

could

RENNIE

permit

1957) (Doi

reported

to

genesis

only

cold

of

cold

1974)

us

the

et

Male

fat 4

(lard), to

to

27.1%

1974).

about

in

the

the

body

25•Ž

for

18hr.

The

the

Blood

time

was

obtained and

Blood

results

of

tested

rats

placed

1955).

test by

there

the

(swimming

by of

to

with

in

rats.

two

diet in

by

to

50.1 calories

They

group

and

rats

for

32•Ž

or

fasted

for

according

surface or

those at

determined

condition

weigh-

difference

a bathtub

the

for

(KUROSHIMA

with

was

return

groups:one

containing

of

the

water.

immediately

after

tube. method

of

ITAYA

(1970)

and

was

measured

lactate reagents.

student-t

as not

concerned

significant

performed

resting

GOSCHKE

Blood

no

out

endurance) able

the

diet

favorably

(25•Ž).

was

standard

also

combination

the

for

test

high-fat

elsewhere

temperature

and

during

1972).

inasmuch

(flour)

described

was

determined method

is

experiment

a heparinized

the

into

carried

decapitation

(ROE,

diets

longer

keto-

al.,

exercise

diet

was

no

of

was

divided

carbohydrate

at room

used

study swimming

also

1971),

influence

a high-fat

swimming

were

in

was

Boehringer was

same

by

by

method

those

exhaustion

the

FFA

bodies

reagent use

to

when

swimming

ketone

The

time

housed experiment

The

were other

22.8%

of

between group.

30min.

150g

of

effect

been

et

responses,

present to

FUWA,

of

con-

has

(BRINGOLF

might

cold

experimental diet

and

study

which to

METHODS

the

and

certain

metabolic

The

and

were

the , time

weight diet

the

(FROEBERG

exposed

High-fat

diet

AND

composition

animals

at

enhance

changes

when a

the of

responses

about MF)

(casein)

full

The

300g

high-fat

weighing

(Oriental

The

to

ex-

ISSEKUTZ

oxidation

metabolic

oxidation

high-fat

metabolic

some

(SUZUKI acid

function.

on

protein

during

1964;

shown

FFA

1974).

consider

by

exercise

rats diet

5 weeks.

et al., ed

to

Wistar

a standard

90%

1963,

been

under

al.,

fatty

MATERIALS

fed

to

al.,

production

viewpoint

induced

diet

cause

heat

tolerance

and

led

, from

but

has

gluconeogenesis

al.,

studies

high-fat

intensity et

through

to of

KUROSHIMA

hepatic

tolerance

effect

higher HAVEL

training

suggested

improve

modifications

and I. FUJITA

1974).

rate

especially

1963;

produced

sustained

et

previous

metabolic

be

been

1974;

increase

exercise,

the

al.,

(KUROSHIMA These

on

al.,

and

et

can

has

higher

(LEBLANC, ditions

et

feeding

of

al.,

physical

that

HAYAMI,

exercise et

Moreover,

energy

diet

during (CARLSON

1966). of

et al.,

20-50%

intensity

proportion

T. OHNO, O.

and

glucose

The

statistical

state

(Tables

UI

(1965),

by

the

enzymatically significance

blood anthrone by

the

of

the

test.

RESULTS Effect

diet

of

exercise

Blood

FFA

(P