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UTI pain mechanisms
Editorial Comment Editorial Comment to Mechanism of pain from urinary tract infection This Review Article by Rosen and Klumpp well summarizes the current status of Escherichia coli-induced urinary tract infection (UTI) and UTI-induced pelvic pain mechanisms, which are potentially involved in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC).1 Although there is so far no direct evidence showing that UTI is a definite cause of BPS/IC, a past history of UTI is reportedly an associated risk factor of BPS/IC. Thus it is possible that past UTI with particular pathogen(s) can precondition the host bladder and/or afferent pathways to be susceptible for other factors or mediators to finally establish the disease condition of BPS/IC. Further studies are needed to identify the correlations of findings in animal models with UTI with those in BPS/IC humans with the past history of UTI induced by different types of pathogens, in terms of the changes in receptor/ion channel expression and the cytokine/chemokine profile in the bladder and neural pathways.
© 2014 The Japanese Urological Association
It is hoped that the future research on UTI-related aspects of chronic pelvic pain development could lead to the discovery of new modalities such as modulation of the particular chemokine axis for the treatment of BPS/IC. Naoki Yoshimura M.D., Ph.D. Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA [email protected] DOI: 10.1111/iju.12310
Conflict of interest None declared.
Reference 1 Rosen JM, Klumpp DJ. Mechanism of pain from urinary tract infection. Int. J. Urol. 2014; 21 (Suppl 1): 26–32.
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UTI pain mechanisms
Editorial Comment Editorial Comment to Mechanism of pain from urinary tract infection This Review Article by Rosen and Klumpp well summarizes the current status of Escherichia coli-induced urinary tract infection (UTI) and UTI-induced pelvic pain mechanisms, which are potentially involved in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC).1 Although there is so far no direct evidence showing that UTI is a definite cause of BPS/IC, a past history of UTI is reportedly an associated risk factor of BPS/IC. Thus it is possible that past UTI with particular pathogen(s) can precondition the host bladder and/or afferent pathways to be susceptible for other factors or mediators to finally establish the disease condition of BPS/IC. Further studies are needed to identify the correlations of findings in animal models with UTI with those in BPS/IC humans with the past history of UTI induced by different types of pathogens, in terms of the changes in receptor/ion channel expression and the cytokine/chemokine profile in the bladder and neural pathways.
© 2014 The Japanese Urological Association
It is hoped that the future research on UTI-related aspects of chronic pelvic pain development could lead to the discovery of new modalities such as modulation of the particular chemokine axis for the treatment of BPS/IC. Naoki Yoshimura M.D., Ph.D. Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA [email protected] DOI: 10.1111/iju.12310
Conflict of interest None declared.
Reference 1 Rosen JM, Klumpp DJ. Mechanism of pain from urinary tract infection. Int. J. Urol. 2014; 21 (Suppl 1): 26–32.
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