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ADC-FNN Online First, published on April 15, 2015 as 10.1136/archdischild-2014-307565 Short research report
Early red cell transfusion favourably alters cerebral oxygen extraction in very preterm newborns CC Andersen,1,2 SM Karayil,1 NA Hodyl,1,2 MJ Stark1,2 1
Department of Neonatal Medicine, Women’s and Children’s Hospital, Adelaide, South Australia, Australia 2 The Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia Correspondence to Dr CC Andersen, Department of Neonatal Medicine, Women’s and Children’s Hospital, Adelaide, SA 5006, Australia; chad.andersen@ health.sa.gov.au Received 18 September 2014 Revised 16 March 2015 Accepted 21 March 2015
ABSTRACT Background Elevated cerebral fractional tissue oxygen extraction (cFTOE; ≥0.4) predicts early brain injury in very preterm infants. While blood transfusion increases oxygen-carrying capacity, its ability to improve cerebral oxygen kinetics in the immediate newborn period remains unknown. Objective To investigate the effect of red blood cell (RBC) transfusion in the first 24 h of life on cFTOE in infants ≤29 weeks gestation. Methods cFTOE was calculated from cerebral tissue oxygenation index (TOI) and cutaneous oximetry measured over a 30 min epoch before and after transfusion. Infants were dichotomised according to pretransfusion cFTOE (low
ADC-FNN Online First, published on April 15, 2015 as 10.1136/archdischild-2014-307565 Short research report
Early red cell transfusion favourably alters cerebral oxygen extraction in very preterm newborns CC Andersen,1,2 SM Karayil,1 NA Hodyl,1,2 MJ Stark1,2 1
Department of Neonatal Medicine, Women’s and Children’s Hospital, Adelaide, South Australia, Australia 2 The Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia Correspondence to Dr CC Andersen, Department of Neonatal Medicine, Women’s and Children’s Hospital, Adelaide, SA 5006, Australia; chad.andersen@ health.sa.gov.au Received 18 September 2014 Revised 16 March 2015 Accepted 21 March 2015
ABSTRACT Background Elevated cerebral fractional tissue oxygen extraction (cFTOE; ≥0.4) predicts early brain injury in very preterm infants. While blood transfusion increases oxygen-carrying capacity, its ability to improve cerebral oxygen kinetics in the immediate newborn period remains unknown. Objective To investigate the effect of red blood cell (RBC) transfusion in the first 24 h of life on cFTOE in infants ≤29 weeks gestation. Methods cFTOE was calculated from cerebral tissue oxygenation index (TOI) and cutaneous oximetry measured over a 30 min epoch before and after transfusion. Infants were dichotomised according to pretransfusion cFTOE (low
