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Research

Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice Joshua L. Allen,1 Xiufang Liu,1 Sean Pelkowski,1 Brian Palmer,1 Katherine Conrad,1 Günter Oberdörster,1 Douglas Weston,1 Margot Mayer-Pröschel,2 and Deborah A. Cory-Slechta1 1Department

of Environmental Medicine, and 2Department of Biomedical Genetics, University of Rochester School of Medicine, Rochester, New York, USA

B ackground : Air pollution has been associated with adverse neuro­logical and behavioral health effects in children and adults. Recent studies link air pollutant exposure to adverse neuro­ developmental outcomes, including increased risk for autism, cognitive decline, ischemic stroke, schizophrenia, and depression. Objectives: We sought to investigate the mechanism(s) by which exposure to ultrafine concen­ trated ambient particles (CAPs) adversely influences central nervous system (CNS) development. Methods: We exposed C57BL6/J mice to ultrafine (

Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice.

Air pollution has been associated with adverse neurological and behavioral health effects in children and adults. Recent studies link air pollutant ex...
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