Research Article
Early periportal sinusoidal fibrosis is an accurate marker of accelerated HCV recurrence after liver transplantation Zoe Mariño1, Laura Mensa1, Gonzalo Crespo1, Rosa Miquel2, Miquel Bruguera1, Sofía Pérez-del-Pulgar1, Jaume Bosch1, Xavier Forns1, Miquel Navasa1,⇑ 1
Liver Unit, Institut de Malalties Digestives, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of Barcelona, Barcelona, Spain; 2Pathology Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
Background & Aims: Significant liver fibrosis (F P2) and portal hypertension (hepatic venous pressure gradient [HVPG] P6 mmHg) 1 year after liver transplantation (LT) are predictors of severe hepatitis C recurrence. Periportal sinusoidal fibrosis (SF) is an early expression of the fibrogenic process in response to liver injury. We aimed to evaluate whether SF in early liver biopsies represents an early and accurate marker for identifying patients with severe HCV recurrence after LT. Methods: A total of 101 HCV LT patients with early biopsy (200 IU/ml, GGT >200 IU/L, AP >600 IU/L, bilirubin >3 mg/dl). Forty-seven patients were excluded from the initial cohort for the following reasons: non-evaluable early samples [n = 30, including, insufficient size (
Early periportal sinusoidal fibrosis is an accurate marker of accelerated HCV recurrence after liver transplantation Zoe Mariño1, Laura Mensa1, Gonzalo Crespo1, Rosa Miquel2, Miquel Bruguera1, Sofía Pérez-del-Pulgar1, Jaume Bosch1, Xavier Forns1, Miquel Navasa1,⇑ 1
Liver Unit, Institut de Malalties Digestives, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of Barcelona, Barcelona, Spain; 2Pathology Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
Background & Aims: Significant liver fibrosis (F P2) and portal hypertension (hepatic venous pressure gradient [HVPG] P6 mmHg) 1 year after liver transplantation (LT) are predictors of severe hepatitis C recurrence. Periportal sinusoidal fibrosis (SF) is an early expression of the fibrogenic process in response to liver injury. We aimed to evaluate whether SF in early liver biopsies represents an early and accurate marker for identifying patients with severe HCV recurrence after LT. Methods: A total of 101 HCV LT patients with early biopsy (200 IU/ml, GGT >200 IU/L, AP >600 IU/L, bilirubin >3 mg/dl). Forty-seven patients were excluded from the initial cohort for the following reasons: non-evaluable early samples [n = 30, including, insufficient size (
