Early Bispectral Index and Sedation Requirements During Therapeutic Hypothermia Predict Neurologic Recovery Following Cardiac Arrest* Nicholas E. Burjek, MD'; Chad E. Wagner, MD'; Ryan D. Hollenbeck, MD^; Li Wang, Chang Yu, PhD^; John A. McPherson, MD^; Frederic T. BiUings IV, MD, MSc'

Objectives: To test the hypothesis that low bispectral index scores and low sedative requirements during therapeutic hypothermia predict poor neurologic outcome. Design: Observational study ot a prospectively collected cohort. Setting: Cardiovascular ICU. Patients: One hundred sixty consecutive cardiac arrest patients treated with therapeutic hypothermia, interventions: None. Measurements and Resuits: Eighty-four of the 141 subjects (60%) who survived hypothermia induction were discharged from the ICU with poor neurologic outcome, defined as a cerebral performance category score of 3, 4, or 5. These subjects had lower bispectral index (p