Original Paper ' Travail original ■Originalarbeit
Ophthalmologica 1992:205:178-186
Giovanni Staurenghi Ferdinando Bottoni Cristina Lonati A lessandro Autelitano Nicola Orzalesi
Drusen and 'Choroidal Filling Defects': A Cross-Sectional Survey
Key Words
Abstract
Age-related macular degeneration Drusen Choroidal filling defects
The present study was designed as a cross-sectional survey to assess the association between soft drusen and ‘choroidal fill ing defects'. Sixty-eight eyes presenting hard drusen and 58 eyes with soft drusen of 126 subjects with an age range of 45-83 years were examined in the present study. Choroidal filling defects were present in 13 out of 68 (19.1%) patients with hard drusen and 29 out of 58 (50%) with soft drusen (-/: square = 13.4: p 75 years. For this analysis, we used the MantelHaenszel test.
Table 3. Choroidal filling defects in hard and soft drusen Drusen type
Table 5. Choroidal filling defects and systemic
hypertension Choroidal filling defects present
absent
Soft Hard
29 13
29 55
Total
42
84
OR = 4.2(95% Cl 1.9-9.3). After adjusting for age OR = 4 .9 (95% CI 1.9-11.7).
Choroidal filling defects
Systemic hypertension present
absent
Patients with, n Patients without, n
15 37
27 47
Total
53
73
X; = 0.7; p =0.8; OR = 0.71 (95% Cl 0.33-1.52).
Table 4. Choroidal filling defects and ocular hy
pertension Ocular hypertension present
Choroidal filling defects
absent
Patients with, n Patients without, n
1 5
41 79
Total
6
120
Diabetes present
absent
Patients with, n Patients without, n
6 15
36 69
Total
21
105
X2 = 0.6: p =0.79: OR = 0.39 (95% Cl 0.004-3.43).
X2 = 0.26; p =0.45; OR = 0.77(95% Cl 0.28-2.14).
fects (69± 10.4 years) and without choroidal filling defects (68±11 years) was similar (t = 1.037; p = 0.302). Choroidal filling defects, identified ac cording to the angiographic characteristics, were present in 13 out of 68 (19.1%) patients with hard drusen and 29 out of 58 (50%) with soft drusen. A definite association between choroidal filling defects and soft drusen was found. The x: value was 13.4 with an associ ated p value
Ophthalmologica 1992:205:178-186
Giovanni Staurenghi Ferdinando Bottoni Cristina Lonati A lessandro Autelitano Nicola Orzalesi
Drusen and 'Choroidal Filling Defects': A Cross-Sectional Survey
Key Words
Abstract
Age-related macular degeneration Drusen Choroidal filling defects
The present study was designed as a cross-sectional survey to assess the association between soft drusen and ‘choroidal fill ing defects'. Sixty-eight eyes presenting hard drusen and 58 eyes with soft drusen of 126 subjects with an age range of 45-83 years were examined in the present study. Choroidal filling defects were present in 13 out of 68 (19.1%) patients with hard drusen and 29 out of 58 (50%) with soft drusen (-/: square = 13.4: p 75 years. For this analysis, we used the MantelHaenszel test.
Table 3. Choroidal filling defects in hard and soft drusen Drusen type
Table 5. Choroidal filling defects and systemic
hypertension Choroidal filling defects present
absent
Soft Hard
29 13
29 55
Total
42
84
OR = 4.2(95% Cl 1.9-9.3). After adjusting for age OR = 4 .9 (95% CI 1.9-11.7).
Choroidal filling defects
Systemic hypertension present
absent
Patients with, n Patients without, n
15 37
27 47
Total
53
73
X; = 0.7; p =0.8; OR = 0.71 (95% Cl 0.33-1.52).
Table 4. Choroidal filling defects and ocular hy
pertension Ocular hypertension present
Choroidal filling defects
absent
Patients with, n Patients without, n
1 5
41 79
Total
6
120
Diabetes present
absent
Patients with, n Patients without, n
6 15
36 69
Total
21
105
X2 = 0.6: p =0.79: OR = 0.39 (95% Cl 0.004-3.43).
X2 = 0.26; p =0.45; OR = 0.77(95% Cl 0.28-2.14).
fects (69± 10.4 years) and without choroidal filling defects (68±11 years) was similar (t = 1.037; p = 0.302). Choroidal filling defects, identified ac cording to the angiographic characteristics, were present in 13 out of 68 (19.1%) patients with hard drusen and 29 out of 58 (50%) with soft drusen. A definite association between choroidal filling defects and soft drusen was found. The x: value was 13.4 with an associ ated p value
