RESEARCH ARTICLE

Drug Transporter Genetic Variants Are Not Associated with TDF-Related Renal Dysfunction in Patients with HIV-1 Infection: A Pharmacogenetic Study Takeshi Nishijima1,2, Tsunefusa Hayashida1, Takuma Kurosawa3,4, Noriko Tanaka4, Shinichi Oka1,2, Hiroyuki Gatanaga1,2*

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1 AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan, 2 Center for AIDS Research, Kumamoto University, Kumamoto, Japan, 3 Department of Mathematical Science for Information Sciences, Graduate School of Science, Tokyo University of Science, Tokyo, Japan, 4 Biostatistics Section, Department of Clinical Research and Informatics, Clinical Science Center, National Center for Global Health and Medicine, Tokyo, Japan * [email protected]

OPEN ACCESS Citation: Nishijima T, Hayashida T, Kurosawa T, Tanaka N, Oka S, Gatanaga H (2015) Drug Transporter Genetic Variants Are Not Associated with TDF-Related Renal Dysfunction in Patients with HIV1 Infection: A Pharmacogenetic Study. PLoS ONE 10(11): e0141931. doi:10.1371/journal.pone.0141931 Editor: Roger Le Grand, Commissariat a l'Energie Atomique(cea), FRANCE Received: July 29, 2015 Accepted: October 14, 2015 Published: November 4, 2015 Copyright: © 2015 Nishijima et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by a Grant-in Aid for AIDS research from the Japanese Ministry of Health, Labour, and Welfare (H23-AIDS-001), The Grant for National Center for Global Health and Medicine (25-106 and 27-6001), and a grants-in-aid of The IMAI MEMORIAL TRUST FOR AIDS RESEARCH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Abstract Objective To investigate whether single nucleotide polymorphisms (SNP) of drug transporter proteins for TDF is a risk factor for TDF-related renal function decrement.

Methods This study investigated the association between 3 SNPs (ABCC2–24, 1249, and ABCB1 2677), which are shown to be associated with TDF-induced tubulopathy, and clinically important renal outcomes (>10ml/min/1.73m2 decrement in eGFR relative to baseline, >25% decrement in eGFR, and eGFR 10ml/min/1.73m2 and those without such decrement (ABCC2: -24, p = 0.53, 1249, p = 0.68; ABCB1: 2677, p = 0.74), nor between those without and with the other two renal outcomes (>25% decrement: ABCC2: -24, p = 0.83, 1249, p = 0.97, ABCB1: 2677, p = 0.40; eGFR

Drug Transporter Genetic Variants Are Not Associated with TDF-Related Renal Dysfunction in Patients with HIV-1 Infection: A Pharmacogenetic Study.

To investigate whether single nucleotide polymorphisms (SNP) of drug transporter proteins for TDF is a risk factor for TDF-related renal function decr...
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